gossylic iminolactone: inhibits human immunodeficiency virus type I replication; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 135487739 |
| CHEMBL ID | 424250 |
| SCHEMBL ID | 2622255 |
| MeSH ID | M0199695 |
| Synonym |
|---|
| (dihydroxy-imino-isopropyl-methyl-[?]yl)-imino-isopropyl-methyl-[?]diol |
| gossylic iminolactone |
| 2,2'-diimino-5,5'-diisopropyl-7,7'-dimethyl-2h, 2'h-[8,8']bi[naphtho[1,8-bc]furanyl]-3,4,3',4'-tetraol |
| CHEMBL424250 , |
| 2,2''-diimino-5,5''-diisopropyl-7,7''-dimethyl-2h,2''h-[8,8'']bi[naphtho[1,8-bc]furanyl]-3,4,3'',4''-tetraol |
| bdbm50010448 |
| (8,8'-bi-2h-naphtho(1,8-bc)furan)-3,3',4,4'-tetrol, 2,2'-diimino-7,7'-dimethyl-5,5'-bis(1-methylethyl)- |
| SCHEMBL2622255 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| L-lactate dehydrogenase A chain | Homo sapiens (human) | Ki | 2.5000 | 0.0500 | 3.7650 | 8.5000 | AID1276043 |
| L-lactate dehydrogenase B chain | Homo sapiens (human) | Ki | 92.0000 | 0.0500 | 0.7700 | 1.4000 | AID1276044 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | Ki | 9.3000 | 0.0190 | 3.4193 | 9.3000 | AID34665 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1276043 | Competitive inhibition of human LDH5 in presence of NADH | 2016 | Journal of medicinal chemistry, Jan-28, Volume: 59, Issue:2 | Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy. |
| AID1276044 | Competitive inhibition of human LDH1 in presence of NADH | 2016 | Journal of medicinal chemistry, Jan-28, Volume: 59, Issue:2 | Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy. |
| AID34665 | The compound was tested for inhibitory activity against Aldose reductase from human placenta | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11 | Gossypol and derivatives: a new class of aldose reductase inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (20.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||