Page last updated: 2024-12-07

gossylic nitrile-1,1'-diacetate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

gossylic nitrile-1,1'-diacetate: inhibits human immunodeficiency virus Type I replication; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID122660
CHEMBL ID51778
MeSH IDM0199698

Synonyms (10)

Synonym
gossylic nitrile-1,1'-diacetate
[2-(1-acetoxy-8-cyano-6,7-dihydroxy-5-isopropyl-3-methyl-2-naphthyl)-8-cyano-6,7-dihydroxy-5-isopropyl-3-methyl-1-naphthyl] acetate
94242-60-1
6,6',7,7'-tetrahydroxy-3,3'-dimethyl-2,2'-diacetoxy-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-, 8,8'-dicarbonitrile
CHEMBL51778 ,
(2,2'-binaphthalene)-8,8'-dicarbonitrile, 1,1'-bis(acetyloxy)-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-
acetic acid 1''-acetoxy-8,8''-dicyano-6,7,6'',7''-tetrahydroxy-5,5''-diisopropyl-3,3''-dimethyl-[2,2'']binaphthalenyl-1-yl ester
bdbm50010438
gn-1,1-da
DTXSID50241224
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
L-lactate dehydrogenase A chainHomo sapiens (human)Ki2.00000.05003.76508.5000AID1276043
L-lactate dehydrogenase B chainHomo sapiens (human)Ki33.00000.05000.77001.4000AID1276044
Aldo-keto reductase family 1 member B1Homo sapiens (human)Ki7.30000.01903.41939.3000AID220721
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (19)

Processvia Protein(s)Taxonomy
lactate metabolic processL-lactate dehydrogenase A chainHomo sapiens (human)
pyruvate metabolic processL-lactate dehydrogenase A chainHomo sapiens (human)
glycolytic processL-lactate dehydrogenase A chainHomo sapiens (human)
lactate metabolic processL-lactate dehydrogenase B chainHomo sapiens (human)
pyruvate metabolic processL-lactate dehydrogenase B chainHomo sapiens (human)
NAD metabolic processL-lactate dehydrogenase B chainHomo sapiens (human)
retinoid metabolic processAldo-keto reductase family 1 member B1Homo sapiens (human)
epithelial cell maturationAldo-keto reductase family 1 member B1Homo sapiens (human)
renal water homeostasisAldo-keto reductase family 1 member B1Homo sapiens (human)
carbohydrate metabolic processAldo-keto reductase family 1 member B1Homo sapiens (human)
prostaglandin metabolic processAldo-keto reductase family 1 member B1Homo sapiens (human)
C21-steroid hormone biosynthetic processAldo-keto reductase family 1 member B1Homo sapiens (human)
L-ascorbic acid biosynthetic processAldo-keto reductase family 1 member B1Homo sapiens (human)
regulation of urine volumeAldo-keto reductase family 1 member B1Homo sapiens (human)
retinol metabolic processAldo-keto reductase family 1 member B1Homo sapiens (human)
negative regulation of apoptotic processAldo-keto reductase family 1 member B1Homo sapiens (human)
daunorubicin metabolic processAldo-keto reductase family 1 member B1Homo sapiens (human)
doxorubicin metabolic processAldo-keto reductase family 1 member B1Homo sapiens (human)
fructose biosynthetic processAldo-keto reductase family 1 member B1Homo sapiens (human)
cellular hyperosmotic salinity responseAldo-keto reductase family 1 member B1Homo sapiens (human)
metanephric collecting duct developmentAldo-keto reductase family 1 member B1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (15)

Processvia Protein(s)Taxonomy
L-lactate dehydrogenase activityL-lactate dehydrogenase A chainHomo sapiens (human)
protein bindingL-lactate dehydrogenase A chainHomo sapiens (human)
identical protein bindingL-lactate dehydrogenase A chainHomo sapiens (human)
cadherin bindingL-lactate dehydrogenase A chainHomo sapiens (human)
L-lactate dehydrogenase activityL-lactate dehydrogenase B chainHomo sapiens (human)
protein bindingL-lactate dehydrogenase B chainHomo sapiens (human)
kinase bindingL-lactate dehydrogenase B chainHomo sapiens (human)
identical protein bindingL-lactate dehydrogenase B chainHomo sapiens (human)
NAD bindingL-lactate dehydrogenase B chainHomo sapiens (human)
retinal dehydrogenase activityAldo-keto reductase family 1 member B1Homo sapiens (human)
aldose reductase (NADPH) activityAldo-keto reductase family 1 member B1Homo sapiens (human)
protein bindingAldo-keto reductase family 1 member B1Homo sapiens (human)
electron transfer activityAldo-keto reductase family 1 member B1Homo sapiens (human)
prostaglandin H2 endoperoxidase reductase activityAldo-keto reductase family 1 member B1Homo sapiens (human)
glyceraldehyde oxidoreductase activityAldo-keto reductase family 1 member B1Homo sapiens (human)
allyl-alcohol dehydrogenase activityAldo-keto reductase family 1 member B1Homo sapiens (human)
L-glucuronate reductase activityAldo-keto reductase family 1 member B1Homo sapiens (human)
glycerol dehydrogenase [NADP+] activityAldo-keto reductase family 1 member B1Homo sapiens (human)
all-trans-retinol dehydrogenase (NADP+) activityAldo-keto reductase family 1 member B1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (11)

Processvia Protein(s)Taxonomy
nucleusL-lactate dehydrogenase A chainHomo sapiens (human)
cytosolL-lactate dehydrogenase A chainHomo sapiens (human)
membraneL-lactate dehydrogenase A chainHomo sapiens (human)
extracellular exosomeL-lactate dehydrogenase A chainHomo sapiens (human)
oxidoreductase complexL-lactate dehydrogenase A chainHomo sapiens (human)
mitochondrionL-lactate dehydrogenase A chainHomo sapiens (human)
cytoplasmL-lactate dehydrogenase B chainHomo sapiens (human)
mitochondrial inner membraneL-lactate dehydrogenase B chainHomo sapiens (human)
cytosolL-lactate dehydrogenase B chainHomo sapiens (human)
membraneL-lactate dehydrogenase B chainHomo sapiens (human)
membrane raftL-lactate dehydrogenase B chainHomo sapiens (human)
extracellular exosomeL-lactate dehydrogenase B chainHomo sapiens (human)
oxidoreductase complexL-lactate dehydrogenase B chainHomo sapiens (human)
mitochondrionL-lactate dehydrogenase B chainHomo sapiens (human)
extracellular spaceAldo-keto reductase family 1 member B1Homo sapiens (human)
nucleoplasmAldo-keto reductase family 1 member B1Homo sapiens (human)
cytosolAldo-keto reductase family 1 member B1Homo sapiens (human)
extracellular exosomeAldo-keto reductase family 1 member B1Homo sapiens (human)
cytosolAldo-keto reductase family 1 member B1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID159611Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCB/NC11986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Biologically active derivatives of gossypol: synthesis and antimalarial activities of peri-acylated gossylic nitriles.
AID99235Compound was tested for the inhibition of LDH from a chloroquine-resistant strain (FCB/NC-1) of Plasmodium falciparum1986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Biologically active derivatives of gossypol: synthesis and antimalarial activities of peri-acylated gossylic nitriles.
AID1276044Competitive inhibition of human LDH1 in presence of NADH2016Journal of medicinal chemistry, Jan-28, Volume: 59, Issue:2
Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy.
AID159613Antimalarial activity against chloroquine-sensitive Plasmodium falciparum CDC/I/HB-31986Journal of medicinal chemistry, Sep, Volume: 29, Issue:9
Biologically active derivatives of gossypol: synthesis and antimalarial activities of peri-acylated gossylic nitriles.
AID1276043Competitive inhibition of human LDH5 in presence of NADH2016Journal of medicinal chemistry, Jan-28, Volume: 59, Issue:2
Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy.
AID220721The compound was tested for inhibitory activity against aldose reductase from human placenta1991Journal of medicinal chemistry, Nov, Volume: 34, Issue:11
Gossypol and derivatives: a new class of aldose reductase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's3 (60.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.87 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]