gossylic lactone: inhibits human immunodeficiency virus type I replication; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 135535745 |
| CHEMBL ID | 110030 |
| SCHEMBL ID | 2622252 |
| MeSH ID | M0199696 |
| Synonym |
|---|
| 2h-naphtho[1,8-bc]furan, bimol. deriv. |
| gossylic lactone |
| [8,8'-bi-2h-naphtho[1,8-bc]furan]-2,2'-dione, 3,3',4,4'-tetrahydroxy-7,7'-dimethyl-5,5'-bis(1-methylethyl)- |
| (dihydroxy-isopropyl-methyl-oxo-[?]yl)-dihydroxy-isopropyl-methyl-[?]one |
| gossypol lactone |
| CHEMBL110030 , |
| bdbm50010449 |
| 3,4,3'',4''-tetrahydroxy-5,5''-diisopropyl-7,7''-dimethyl-[8,8'']bi[naphtho[1,8-bc]furanyl]-2,2''-dione |
| 3,3',4,4'-tetrahydroxy-7,7'-dimethyl-5,5'-bis(1-methylethyl)-(8,8'-bi-2h-naphtho(1,8-bc)furan)-2,2'-dione |
| (8,8'-bi-2h-naphtho(1,8-bc)furan)-2,2'-dione, 3,3',4,4'-tetrahydroxy-7,7'-dimethyl-5,5'-bis(1-methylethyl)- |
| SCHEMBL2622252 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| L-lactate dehydrogenase A chain | Homo sapiens (human) | Ki | 0.6000 | 0.0500 | 3.7650 | 8.5000 | AID1276043 |
| L-lactate dehydrogenase B chain | Homo sapiens (human) | Ki | 0.4000 | 0.0500 | 0.7700 | 1.4000 | AID1276044 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | Ki | 0.1500 | 0.0190 | 3.4193 | 9.3000 | AID220721 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID220721 | The compound was tested for inhibitory activity against aldose reductase from human placenta | 1991 | Journal of medicinal chemistry, Nov, Volume: 34, Issue:11 | Gossypol and derivatives: a new class of aldose reductase inhibitors. |
| AID1276044 | Competitive inhibition of human LDH1 in presence of NADH | 2016 | Journal of medicinal chemistry, Jan-28, Volume: 59, Issue:2 | Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy. |
| AID1276043 | Competitive inhibition of human LDH5 in presence of NADH | 2016 | Journal of medicinal chemistry, Jan-28, Volume: 59, Issue:2 | Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (20.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||