Compounds > droprenylamine
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droprenylamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

Droprenylamine is a potent and selective inhibitor of the enzyme monoamine oxidase-A (MAO-A). MAO-A is an enzyme that breaks down neurotransmitters such as serotonin, norepinephrine, and dopamine in the brain. Inhibition of MAO-A can lead to increased levels of these neurotransmitters, which can have a variety of effects on mood, cognition, and behavior. Droprenylamine has been studied as a potential treatment for depression, anxiety, and other psychiatric disorders. Its mechanism of action, selectivity, and potential therapeutic applications make it an area of ongoing research. However, it is important to note that droprenylamine is not currently approved for use in humans and further research is needed to assess its safety and efficacy.'

droprenylamine: secondary amine structurally related to prenylamine; RN given refers to parent cpd; synonym MG 8926 refers to HCl; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID65470
CHEMBL ID2106278
CHEBI ID135426
SCHEMBL ID123362
MeSH IDM0061819

Synonyms (31)

Synonym
D03915
57653-27-7
valcor (tn)
droprenilamine (usan/inn)
droprenylamine
droprenilamine
CHEBI:135426
n-(1-cyclohexylpropan-2-yl)-3,3-diphenylpropan-1-amine
(+-)-n-(3,3-diphenylpropyl)-alpha-methylcyclohexaneethylamine
droprenilamina [inn-spanish]
droprenilaminum
droprenilamine [usan:inn]
31ipx0zd7r ,
benzenepropanamine, n-(2-cyclohexyl-1-methylethyl)-gamma-phenyl-, (+-)-
m.g. 8926 [as hydrochloride]
droprenilamina
valcor
unii-31ipx0zd7r
droprenilaminum [inn-latin]
CHEMBL2106278
m.g. 8926 free base
SCHEMBL123362
mg-8926 free base
droprenilamine [mi]
droprenilamine [inn]
(+/-)-n-(3,3-diphenylpropyl)-.alpha.-methylcyclohexaneethylamine
benzenepropanamine, n-(2-cyclohexyl-1-methylethyl)-.gamma.-phenyl-, (+/-)-
droprenilamine [usan]
Q27256057
DTXSID10866639
AKOS040751643
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
diarylmethaneAny compound containing two aryl groups connected by a single C atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (80.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (20.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		1.9910aromatic ether;
nitrile;
polyether;
tertiary amino compound
prenylamine
Prenylamine: A drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1406)		4.4451diarylmethane
ouabain
Ouabain: A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.. cardiac glycoside : Steroid lactones containing sugar residues that act on the contractile force of the cardiac muscles.. ouabain : A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.		1.951011alpha-hydroxy steroid;
14beta-hydroxy steroid;
5beta-hydroxy steroid;
alpha-L-rhamnoside;
cardenolide glycoside;
steroid hormone		anti-arrhythmia drug;
cardiotonic drug;
EC 2.3.3.1 [citrate (Si)-synthase] inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
ion transport inhibitor;
plant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Angor Pectoris
[description not available]		03.7521
Coronary Heart Disease
[description not available]		04.0331
Angina Pectoris
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.		03.7521
Coronary Disease
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.		04.0331
Arrhythmia
[description not available]		01.9510
Arrhythmias, Cardiac
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.		01.9510