Page last updated: 2024-11-12

daa 1106

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Cross-References

ID SourceID
PubMed CID10430788
CHEMBL ID63064
SCHEMBL ID4190583
MeSH IDM0304664

Synonyms (22)

Synonym
n-(2,5-dimethoxy-benzyl)-n-(5-fluoro-2-phenoxy-phenyl)-acetamide
n-(2,5-dimethoxybenzyl)-n-(5-fluoro-2-phenoxyphenyl)acetamide
bdbm50122293
n-(2,5-dimethoxybenzyl)-n-(5-fluoro-2-phenoxyphenyl)-acetamide
CHEMBL63064 ,
n-[(2,5-dimethoxyphenyl)methyl]-n-(5-fluoro-2-phenoxyphenyl)acetamide
daa-1106
220551-92-8
SCHEMBL4190583
DTXSID30439829
CS-5474
HY-19945
EX-A1214
AKOS030526724
daa1106
Q5204188
unii-3a8ivt5q3p
acetamide, n-((2,5-dimethoxyphenyl)methyl)-n-(5-fluoro-2-phenoxyphenyl)-
n-((2,5-dimethoxyphenyl)methyl)-n-(5-fluoro-2-phenoxyphenyl)acetamide
3A8IVT5Q3P ,
F85368
MS-26653
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (18)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)IC50 (µMol)5.00080.00010.507510.0000AID40237; AID40238
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Ki1.00000.00020.656110.0000AID52213
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)IC50 (µMol)5.00080.00010.507510.0000AID40237; AID40238
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Ki1.00000.00020.656110.0000AID52213
Translocator proteinRattus norvegicus (Norway rat)IC50 (µMol)0.00160.00010.63934.8100AID40238
Translocator proteinRattus norvegicus (Norway rat)Ki0.00030.00010.65108.9300AID367620; AID678665
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)IC50 (µMol)5.00080.00010.507510.0000AID40237; AID40238
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Ki1.00000.00020.656110.0000AID52213
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)IC50 (µMol)5.00080.00010.505710.0000AID40237; AID40238
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Ki1.00000.00020.561410.0000AID52213
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)IC50 (µMol)5.00080.00010.497310.0000AID40237; AID40238
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Ki1.00000.00020.635210.0000AID52213
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)IC50 (µMol)5.00080.00010.507510.0000AID40237; AID40238
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Ki1.00000.00020.621710.0000AID52213
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)IC50 (µMol)5.00080.00010.498810.0000AID40237; AID40238
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Ki1.00000.00020.675810.0000AID52213
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)IC50 (µMol)5.00080.00010.504610.0000AID40237; AID40238
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Ki1.00000.00020.646910.0000AID52213
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)IC50 (µMol)5.00080.00010.507510.0000AID40237; AID40238
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Ki1.00000.00020.656110.0000AID52213
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)IC50 (µMol)5.00080.00010.507510.0000AID40237; AID40238
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Ki1.00000.00020.656110.0000AID52213
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)IC50 (µMol)5.00080.00010.507510.0000AID40237; AID40238
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Ki1.00000.00020.671210.0000AID52213
Translocator proteinHomo sapiens (human)IC50 (µMol)0.00030.00030.13020.4900AID1849513
Translocator proteinHomo sapiens (human)Ki0.00020.00020.02160.0988AID1198725; AID367622; AID41743
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)IC50 (µMol)5.00080.00010.506510.0000AID40237; AID40238
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Ki1.00000.00020.557710.0000AID52213
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)IC50 (µMol)5.00080.00010.505710.0000AID40237; AID40238
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Ki1.00000.00020.640310.0000AID52213
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)IC50 (µMol)5.00080.00010.507510.0000AID40237; AID40238
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Ki1.00000.00020.570810.0000AID52213
GABA theta subunitRattus norvegicus (Norway rat)IC50 (µMol)5.00080.00010.507510.0000AID40237; AID40238
GABA theta subunitRattus norvegicus (Norway rat)Ki1.00000.00020.656110.0000AID52213
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)IC50 (µMol)5.00080.00010.507510.0000AID40237; AID40238
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Ki1.00000.00020.656110.0000AID52213
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (39)

Processvia Protein(s)Taxonomy
protein targeting to mitochondrionTranslocator proteinHomo sapiens (human)
C21-steroid hormone biosynthetic processTranslocator proteinHomo sapiens (human)
heme biosynthetic processTranslocator proteinHomo sapiens (human)
monoatomic anion transportTranslocator proteinHomo sapiens (human)
chloride transportTranslocator proteinHomo sapiens (human)
steroid metabolic processTranslocator proteinHomo sapiens (human)
glial cell migrationTranslocator proteinHomo sapiens (human)
response to xenobiotic stimulusTranslocator proteinHomo sapiens (human)
response to manganese ionTranslocator proteinHomo sapiens (human)
response to vitamin B1Translocator proteinHomo sapiens (human)
peripheral nervous system axon regenerationTranslocator proteinHomo sapiens (human)
sterol transportTranslocator proteinHomo sapiens (human)
adrenal gland developmentTranslocator proteinHomo sapiens (human)
negative regulation of protein ubiquitinationTranslocator proteinHomo sapiens (human)
regulation of cholesterol transportTranslocator proteinHomo sapiens (human)
response to progesteroneTranslocator proteinHomo sapiens (human)
negative regulation of tumor necrosis factor productionTranslocator proteinHomo sapiens (human)
response to testosteroneTranslocator proteinHomo sapiens (human)
regulation of cell population proliferationTranslocator proteinHomo sapiens (human)
cholesterol homeostasisTranslocator proteinHomo sapiens (human)
positive regulation of apoptotic processTranslocator proteinHomo sapiens (human)
negative regulation of nitric oxide biosynthetic processTranslocator proteinHomo sapiens (human)
behavioral response to painTranslocator proteinHomo sapiens (human)
regulation of steroid biosynthetic processTranslocator proteinHomo sapiens (human)
positive regulation of mitochondrial depolarizationTranslocator proteinHomo sapiens (human)
positive regulation of calcium ion transportTranslocator proteinHomo sapiens (human)
contact inhibitionTranslocator proteinHomo sapiens (human)
positive regulation of glial cell proliferationTranslocator proteinHomo sapiens (human)
negative regulation of glial cell proliferationTranslocator proteinHomo sapiens (human)
positive regulation of programmed necrotic cell deathTranslocator proteinHomo sapiens (human)
cellular response to lipopolysaccharideTranslocator proteinHomo sapiens (human)
cellular response to zinc ionTranslocator proteinHomo sapiens (human)
cellular hypotonic responseTranslocator proteinHomo sapiens (human)
maintenance of protein location in mitochondrionTranslocator proteinHomo sapiens (human)
negative regulation of mitophagyTranslocator proteinHomo sapiens (human)
negative regulation of ATP metabolic processTranslocator proteinHomo sapiens (human)
response to acetylcholineTranslocator proteinHomo sapiens (human)
positive regulation of reactive oxygen species metabolic processTranslocator proteinHomo sapiens (human)
negative regulation of corticosterone secretionTranslocator proteinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (6)

Processvia Protein(s)Taxonomy
androgen bindingTranslocator proteinHomo sapiens (human)
protein bindingTranslocator proteinHomo sapiens (human)
benzodiazepine receptor activityTranslocator proteinHomo sapiens (human)
cholesterol bindingTranslocator proteinHomo sapiens (human)
transmembrane transporter bindingTranslocator proteinHomo sapiens (human)
cholesterol transfer activityTranslocator proteinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (8)

Processvia Protein(s)Taxonomy
plasma membraneGamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)
mitochondrionTranslocator proteinHomo sapiens (human)
mitochondrial outer membraneTranslocator proteinHomo sapiens (human)
cytosolTranslocator proteinHomo sapiens (human)
intracellular membrane-bounded organelleTranslocator proteinHomo sapiens (human)
extracellular exosomeTranslocator proteinHomo sapiens (human)
endoplasmic reticulumTranslocator proteinHomo sapiens (human)
membraneTranslocator proteinHomo sapiens (human)
plasma membraneGamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)
plasma membraneGamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (36)

Assay IDTitleYearJournalArticle
AID277960Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse striatum at 1 mg/kg, iv after 30 mins relative to control2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
AID277964Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in Sprague-Dawley rat choroids plexus at1 mg/kg, iv after 30 mins relative to control2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
AID264318Distribution coefficient of the compound, log D2006Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
[2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis, uptake, and in vivo binding in brain.
AID277968Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from in Sprague-Dawley rat frontal cortex at 1 mg/kg, iv after 30 mins relative to control2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
AID277962Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse hypothalamus at 1 mg/kg, iv after 30 mins relative to control2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
AID40504In vitro binding affinity for PBR (peripheral benzodiazepine receptor) in rat brain2003Bioorganic & medicinal chemistry letters, Jan-20, Volume: 13, Issue:2
[18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR).
AID367620Displacement of [3H]PK11195 from rat PBR receptor2009Journal of medicinal chemistry, Feb-12, Volume: 52, Issue:3
Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET.
AID264315Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBR2006Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
[2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis, uptake, and in vivo binding in brain.
AID19016Partition coefficient (logP)2003Bioorganic & medicinal chemistry letters, Jan-20, Volume: 13, Issue:2
[18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR).
AID277912Displacement of [11C]flumazenil from CBR in Sprague-Dawley rat brain2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
AID277966Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in Sprague-Dawley rat cerebellum at 1 mg/kg, iv after 30 mins relative to control2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
AID52213In vitro inhibition of [11C]flumazenil binding to GABA-A central benzodiazepine receptor of rat brain2004Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9
Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain.
AID264321Decrease in uptake in iv dosed Sprague-Dawley rat brain cerebellum after 30 mins per gram of wet tissue in presence of 1 mg/kg DAA11062006Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
[2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis, uptake, and in vivo binding in brain.
AID1849515Displacement of [3H]flunitrazepam from CBR receptor in rat brain cerebral cortex by liquid scintillation spectrometer method2021European journal of medicinal chemistry, Jan-01, Volume: 209An update into the medicinal chemistry of translocator protein (TSPO) ligands.
AID264317Displacement of [11C]Flumazenil from Sprague-Dawley rat brain CBR2006Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
[2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis, uptake, and in vivo binding in brain.
AID277911Displacement of [11C]PK-11195 from PBR in Sprague-Dawley rat brain2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
AID1849513Inhibition of TSPO receptor (unknown origin)2021European journal of medicinal chemistry, Jan-01, Volume: 209An update into the medicinal chemistry of translocator protein (TSPO) ligands.
AID41743In vitro binding affinity for PBR (peripheral benzodiazepine receptor) in monkey brain2003Bioorganic & medicinal chemistry letters, Jan-20, Volume: 13, Issue:2
[18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR).
AID277967Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in Sprague-Dawley rat striatum at 1 mg/kg, iv after 30 mins relative to control2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
AID277959Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse cerebellum at 1 mg/kg, iv after 30 mins relative to control2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
AID277970Distribution coefficient, log D at pH 7.4 by shake flask method2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
AID40238In vitro displacement of [11C]DAA1106 from PBR (peripheral benzodiazepine receptor) of rat brain2003Bioorganic & medicinal chemistry letters, Jan-20, Volume: 13, Issue:2
[18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR).
AID277910Displacement of [11C]DAA1106 from PBR in Sprague-Dawley rat brain2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
AID277961Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse hippocampus at 1 mg/kg, iv after 30 mins relative to control2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
AID24191Partition coefficient of the compound2004Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9
Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain.
AID678665Displacement of [3H]PK11195 from TSPO in Wistar rat heart incubated for 15 mins2012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
Exploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein--potential novel positron emitting tomography imaging agents.
AID157391In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brain2004Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9
Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain.
AID1198725Inhibition of human TSPO2015European journal of medicinal chemistry, Mar-26, Volume: 93Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO).
AID367622Displacement of [3H]PK11195 from human PBR receptor2009Journal of medicinal chemistry, Feb-12, Volume: 52, Issue:3
Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET.
AID125844Concentration (i.v.) was tested for time activity curve (TAC) in the occipital cortex of monkey brain2004Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9
Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain.
AID277958Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse olfactory bulb at 1 mg/kg, iv after 30 mins relative to control2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
AID367621Displacement of [3H]PK11195 from monkey PBR receptor2009Journal of medicinal chemistry, Feb-12, Volume: 52, Issue:3
Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET.
AID264316Displacement of [11C]DAA1106 from Sprague-Dawley rat brain PBR2006Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
[2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis, uptake, and in vivo binding in brain.
AID277965Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in Sprague-Dawley rat olfactory bulb at 1 mg/kg, iv after 30 mins relative to control2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
AID277963Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse cerebral cortex at 1 mg/kg, iv after 30 mins relative to control2007Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
AID40237In vitro displacement of [11C]Flumazenil from (CBR) central GABA-A benzodiazepine receptor of rat brain2003Bioorganic & medicinal chemistry letters, Jan-20, Volume: 13, Issue:2
[18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (62.50)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]