| AID277960 | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse striatum at 1 mg/kg, iv after 30 mins relative to control | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain. |
| AID277964 | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in Sprague-Dawley rat choroids plexus at1 mg/kg, iv after 30 mins relative to control | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain. |
| AID264318 | Distribution coefficient of the compound, log D | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
| [2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis, uptake, and in vivo binding in brain. |
| AID277968 | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from in Sprague-Dawley rat frontal cortex at 1 mg/kg, iv after 30 mins relative to control | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain. |
| AID277962 | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse hypothalamus at 1 mg/kg, iv after 30 mins relative to control | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain. |
| AID40504 | In vitro binding affinity for PBR (peripheral benzodiazepine receptor) in rat brain | 2003 | Bioorganic & medicinal chemistry letters, Jan-20, Volume: 13, Issue:2
| [18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR). |
| AID367620 | Displacement of [3H]PK11195 from rat PBR receptor | 2009 | Journal of medicinal chemistry, Feb-12, Volume: 52, Issue:3
| Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET. |
| AID264315 | Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBR | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
| [2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis, uptake, and in vivo binding in brain. |
| AID19016 | Partition coefficient (logP) | 2003 | Bioorganic & medicinal chemistry letters, Jan-20, Volume: 13, Issue:2
| [18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR). |
| AID277912 | Displacement of [11C]flumazenil from CBR in Sprague-Dawley rat brain | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain. |
| AID277966 | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in Sprague-Dawley rat cerebellum at 1 mg/kg, iv after 30 mins relative to control | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain. |
| AID52213 | In vitro inhibition of [11C]flumazenil binding to GABA-A central benzodiazepine receptor of rat brain | 2004 | Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9
| Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain. |
| AID264321 | Decrease in uptake in iv dosed Sprague-Dawley rat brain cerebellum after 30 mins per gram of wet tissue in presence of 1 mg/kg DAA1106 | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
| [2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis, uptake, and in vivo binding in brain. |
| AID1849515 | Displacement of [3H]flunitrazepam from CBR receptor in rat brain cerebral cortex by liquid scintillation spectrometer method | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | An update into the medicinal chemistry of translocator protein (TSPO) ligands. |
| AID264317 | Displacement of [11C]Flumazenil from Sprague-Dawley rat brain CBR | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
| [2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis, uptake, and in vivo binding in brain. |
| AID277911 | Displacement of [11C]PK-11195 from PBR in Sprague-Dawley rat brain | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain. |
| AID1849513 | Inhibition of TSPO receptor (unknown origin) | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | An update into the medicinal chemistry of translocator protein (TSPO) ligands. |
| AID41743 | In vitro binding affinity for PBR (peripheral benzodiazepine receptor) in monkey brain | 2003 | Bioorganic & medicinal chemistry letters, Jan-20, Volume: 13, Issue:2
| [18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR). |
| AID277967 | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in Sprague-Dawley rat striatum at 1 mg/kg, iv after 30 mins relative to control | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain. |
| AID277959 | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse cerebellum at 1 mg/kg, iv after 30 mins relative to control | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain. |
| AID277970 | Distribution coefficient, log D at pH 7.4 by shake flask method | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain. |
| AID40238 | In vitro displacement of [11C]DAA1106 from PBR (peripheral benzodiazepine receptor) of rat brain | 2003 | Bioorganic & medicinal chemistry letters, Jan-20, Volume: 13, Issue:2
| [18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR). |
| AID277910 | Displacement of [11C]DAA1106 from PBR in Sprague-Dawley rat brain | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain. |
| AID277961 | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse hippocampus at 1 mg/kg, iv after 30 mins relative to control | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain. |
| AID24191 | Partition coefficient of the compound | 2004 | Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9
| Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain. |
| AID678665 | Displacement of [3H]PK11195 from TSPO in Wistar rat heart incubated for 15 mins | 2012 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
| Exploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein--potential novel positron emitting tomography imaging agents. |
| AID157391 | In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brain | 2004 | Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9
| Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain. |
| AID1198725 | Inhibition of human TSPO | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO). |
| AID367622 | Displacement of [3H]PK11195 from human PBR receptor | 2009 | Journal of medicinal chemistry, Feb-12, Volume: 52, Issue:3
| Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET. |
| AID125844 | Concentration (i.v.) was tested for time activity curve (TAC) in the occipital cortex of monkey brain | 2004 | Journal of medicinal chemistry, Apr-22, Volume: 47, Issue:9
| Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain. |
| AID277958 | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse olfactory bulb at 1 mg/kg, iv after 30 mins relative to control | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain. |
| AID367621 | Displacement of [3H]PK11195 from monkey PBR receptor | 2009 | Journal of medicinal chemistry, Feb-12, Volume: 52, Issue:3
| Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET. |
| AID264316 | Displacement of [11C]DAA1106 from Sprague-Dawley rat brain PBR | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
| [2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis, uptake, and in vivo binding in brain. |
| AID277965 | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in Sprague-Dawley rat olfactory bulb at 1 mg/kg, iv after 30 mins relative to control | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain. |
| AID277963 | Displacement of [125I]N-(5-fluoro-2-phenoxyphenyl)-N-(2-iodo-5-methoxybenzyl)acetamide from PBR in ddy mouse cerebral cortex at 1 mg/kg, iv after 30 mins relative to control | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain. |
| AID40237 | In vitro displacement of [11C]Flumazenil from (CBR) central GABA-A benzodiazepine receptor of rat brain | 2003 | Bioorganic & medicinal chemistry letters, Jan-20, Volume: 13, Issue:2
| [18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR). |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |