Page last updated: 2024-12-08

(r)-(11c)1-(2-chlorophenyl)-n-methyl-n-(1-methylpropyl)-3-isoquinolinecarboxamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

You're asking about a very specific chemical compound: **(r)-(11c)1-(2-chlorophenyl)-n-methyl-n-(1-methylpropyl)-3-isoquinolinecarboxamide**. While I can't provide medical or research advice, I can help break down the information and give you some context for why it might be important:

**Understanding the Compound's Name:**

* **(r):** This indicates the compound has a chiral center (a carbon atom bonded to four different groups) and that it's the *R* enantiomer, meaning it has a specific three-dimensional arrangement of its atoms.
* **(11c):** This likely refers to a specific configuration of the molecule. It's impossible to know the exact meaning without additional information or a chemical structure.
* **1-(2-chlorophenyl):** This tells us there is a 2-chlorophenyl group (a benzene ring with a chlorine atom attached at the 2-position) attached to the first position of the molecule's core structure.
* **n-methyl-n-(1-methylpropyl):** This indicates that two nitrogen atoms (the 'N's) are part of the structure. One is bonded to a methyl group (CH3), and the other is bonded to a 1-methylpropyl group (CH3CH2CH(CH3)).
* **3-isoquinolinecarboxamide:** This is the core structure. Isoquinoline is a specific type of aromatic ring system. 3-carboxamide means a carboxamide group (CONH2) is attached to the 3-position of this ring system.

**Why It Might Be Important in Research:**

The structure of this compound suggests it could be a **potential drug candidate**. Here's why:

* **Chiral Center:** The (r) designation means this compound has a chiral center. This is significant because often, only one enantiomer (R or S) of a chiral molecule will have the desired biological activity, while the other might be inactive or even harmful.
* **Aromatic Ring System:** Isoquinoline is a common structural feature in many pharmaceuticals. It often contributes to the molecule's binding affinity to specific biological targets.
* **Functional Groups:** The combination of a 2-chlorophenyl group, carboxamide group, and the N-alkyl groups can influence how the molecule interacts with enzymes, receptors, or other cellular targets.

**Possible Areas of Research:**

* **Pharmacology:** This compound could be investigated as a potential therapeutic for a variety of diseases or conditions, particularly those involving the central nervous system.
* **Medicinal Chemistry:** Researchers might be trying to optimize the structure of this compound to improve its potency, selectivity, or pharmacokinetic properties (how it's absorbed, distributed, metabolized, and excreted).

**Important Note:** Without more context, it's impossible to say for sure what specific research area this compound is relevant to.

**To learn more:**

* You'll need access to scientific databases and publications related to drug discovery and development.
* Look for research papers that mention this compound name or a similar structure.
* If you have a source that provides additional information, like a chemical structure or the research context, it would be helpful to include it.

Cross-References

ID SourceID
PubMed CID450825
CHEMBL ID1817977
SCHEMBL ID12790424
MeSH IDM0489761

Synonyms (14)

Synonym
[11C]PK11195
1-(2-chlorophenyl)-n-[11c]methyl-n-(1-methylpropyl)-3-isoquinoline carboxamide
MOLI001365
CHEMBL1817977
124236-60-8
82wt506r12 ,
1-(2-chlorophenyl)-n-methyl-n-(1-methylpropyl)-3-isoquinolinecarboxamide c-11
pk-11195 c-11
unii-82wt506r12
(11c)pk11195
(11c)pk 11195
SCHEMBL12790424
n-butan-2-yl-1-(2-chlorophenyl)-n-(111c)methylisoquinoline-3-carboxamide
Q27269361
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (17)

Assay IDTitleYearJournalArticle
AID678669Ratio of biodistribution in olfactory bulbs to striatum of in naive Wistar rat at 1 to 3 MBq, iv using [18F] labeled compound measured 30 mins post dose2012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
Exploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein--potential novel positron emitting tomography imaging agents.
AID678668Biodistribution in naive Wistar rat olfactory bulbs at 1 to 3 MBq, iv using [18F] labeled compound measured 30 mins post dose2012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
Exploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein--potential novel positron emitting tomography imaging agents.
AID644069Biodistribution in Sprague-Dawley rat olfactory bulbs at 1 to 3 MBq, iv after 30 mins by gamma counting2012Bioorganic & medicinal chemistry letters, Feb-01, Volume: 22, Issue:3
[¹⁸F]GE-180: a novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO).
AID644068Biodistribution in Sprague-Dawley rat whole brain at 1 to 3 MBq, iv after 2 mins by gamma counting2012Bioorganic & medicinal chemistry letters, Feb-01, Volume: 22, Issue:3
[¹⁸F]GE-180: a novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO).
AID644071Ratio of drug uptake in striatum in Sprague-Dawley rat at 1 to 3 MBq, iv after 2 mins to drug uptake in striatum in Sprague-Dawley rat at 1 to 3 MBq, iv after 30 mins2012Bioorganic & medicinal chemistry letters, Feb-01, Volume: 22, Issue:3
[¹⁸F]GE-180: a novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO).
AID678671Stability in naive Wistar rat brain assessed as parent compound level at 1 to 3 MBq, iv using [18F] labeled compound measured 60 mins post dose2012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
Exploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein--potential novel positron emitting tomography imaging agents.
AID613586Drug uptake in rat striatum after 1-2 mins post injection2011Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16
Synthesis of 6-[¹⁸F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET.
AID644072Metabolic stability in Sprague-Dawley rat brain assessed as compound remaining at 1 to 3 MBq, iv after 60 mins by HPLC analysis2012Bioorganic & medicinal chemistry letters, Feb-01, Volume: 22, Issue:3
[¹⁸F]GE-180: a novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO).
AID744030Biodistribution in Wistar rat whole brain after 2 mins2013Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8
Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligands-potential novel positron emitting tomography imaging agents.
AID744028Biodistribution in Wistar rat brain after 30 mins2013Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8
Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligands-potential novel positron emitting tomography imaging agents.
AID678667Biodistribution in naive Wistar rat whole brain at 1 to 3 MBq, iv using [18F] labeled compound measured 2 mins post dose2012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
Exploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein--potential novel positron emitting tomography imaging agents.
AID644070Ratio of drug uptake in olfactory bulb to striatum in Sprague-Dawley rat at 1 to 3 MBq, iv after 30 mins by gamma counting2012Bioorganic & medicinal chemistry letters, Feb-01, Volume: 22, Issue:3
[¹⁸F]GE-180: a novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO).
AID678670Ratio of biodistribution in striatum at 2 mins post dose to biodistribution in striatum post 30 mins in naive Wistar rat at 1 to 3 MBq, iv using [18F] labeled compound2012Bioorganic & medicinal chemistry letters, Sep-15, Volume: 22, Issue:18
Exploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein--potential novel positron emitting tomography imaging agents.
AID613585Drug uptake in AMPA lesioned rat striatum after 1-2 mins post injection2011Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16
Synthesis of 6-[¹⁸F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET.
AID744027Ratio of drug uptake in Wistar rat brain to Wistar rat striatum after 30 mins2013Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8
Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligands-potential novel positron emitting tomography imaging agents.
AID744026Ratio of drug uptake in Wistar rat striatum after 2 mins to Wistar rat striatum after 30 mins2013Bioorganic & medicinal chemistry letters, Apr-15, Volume: 23, Issue:8
Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligands-potential novel positron emitting tomography imaging agents.
AID1076458Ratio of drug level from ipsilateral to contralateral in Wistar rat administered as iv measured after 60 mins of postinjection by MicroPET imaging analysis2014Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6
Preparation and evaluation of novel pyrazolo[1,5-a]pyrimidine acetamides, closely related to DPA-714, as potent ligands for imaging the TSPO 18kDa with PET.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]