Page last updated: 2024-12-10

ck-869

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	3574452
CHEMBL ID	3261538
SCHEMBL ID	19399667
MeSH ID	M0589692

Synonyms (29)

Synonym
EU-0093645
CHEMDIVAM_000348
CHEMDIV1_012738
HMS623C22
AKOS002089815
2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one
CCG-33400
S6954
CHEMBL3261538
AKOS021653521
ck-869 ,
388592-44-7
ck 869
ck-0157869
2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone
sr-01000553731
SR-01000553731-1
SCHEMBL19399667
2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)thiazolidin-4-one
HY-16927
CS-0012974
BS-17180
ck869
EX-A2784
BCP29868
ck 869; ck869; ck-0157869; ck 0157869; ck0157869
D80737
2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-4-
AC-35688

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay ID	Title	Year	Journal	Article
AID1143069	Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay	2014	European journal of medicinal chemistry, Jun-10, Volume: 80	Optimization of 2-(3-(arylalkyl amino carbonyl) phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone derivatives as potent antitumor growth and metastasis agents.
AID1143070	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay	2014	European journal of medicinal chemistry, Jun-10, Volume: 80	Optimization of 2-(3-(arylalkyl amino carbonyl) phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone derivatives as potent antitumor growth and metastasis agents.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).	2014	Journal of biomolecular screening, Jul, Volume: 19, Issue:6	A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	5 (71.43)	24.3611
2020's	2 (28.57)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	22.39 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.57 (4.65)
Search Engine Demand Index	19.78 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (22.39)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
uracil 2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder	2.31	1	pyrimidine nucleobase; pyrimidone	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; prodrug; Saccharomyces cerevisiae metabolite
thiazoles [no description available]	2.17	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
ck-0944666 CK-0944666: structure in first source. CK-666 : A member of the class of indoles that is 2-methyltryptamine in which a hydrogen attached to the primary amino group has been replaced by a 2-fluorobenzoyl group. It is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex which works by binding to Arp2/3 complex, stabilising the inactive state of the complex and preventing its movement into the active conformation.	2.08	1	benzamides; indoles; organofluorine compound	actin polymerisation inhibitor
indium Indium: A metallic element, atomic number 49, atomic weight 114.818, symbol In. It is named from its blue line in the spectrum.. indium atom : A metallic element first identified and named from the brilliant indigo (Latin indicum) blue line in its flame spectrum.	2.17	1	boron group element atom
gallium Gallium: A rare, metallic element designated by the symbol, Ga, atomic number 31, and atomic weight 69.72.. gallium atom : A metallic element predicted as eka-aluminium by Mendeleev in 1870 and discovered by Paul-Emile Lecoq de Boisbaudran in 1875. Named in honour of France (Latin Gallia) and perhaps also from the Latin gallus cock, a translation of Lecoq.	2.17	1	boron group element atom

Condition	Relationship Strength	Studies
Plasmodium falciparum Malaria [description not available]	2.1	1
Malaria, Falciparum Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	2.1	1
Breast Cancer [description not available]	2.1	1
Cancer of Lung [description not available]	2.1	1
Metastase [description not available]	2.1	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.1	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.1	1
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.1	1

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