Page last updated: 2024-12-07
bw-a 78u
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Description
9-(2-fluorobenzyl)-6-(methylamino)-9H-purine: RN from first source; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 127779 |
CHEMBL ID | 445098 |
CHEMBL ID | 7359 |
SCHEMBL ID | 1883213 |
MeSH ID | M0144143 |
Synonyms (30)
Synonym |
---|
bw-a 78u |
bw-a78u |
9-(2-fluorobenzyl)-6-(methylamino)-9h-purine |
bw a78u |
9h-purin-6-amine, 9-((2-fluorophenyl)methyl)-n-methyl- |
9-((2-fluorophenyl)methyl)-n-methyl-9h-purin-6-amine |
brn 4517870 |
bw-a-78u |
CHEMBL445098 , |
CHEMBL7359 |
bdbm50058210 |
[9-(2-fluoro-benzyl)-9h-purin-6-yl]-methyl-amine; compound with methanesulfonic acid |
9-[(2-fluorophenyl)methyl]-n-methylpurin-6-amine |
SCHEMBL1883213 |
dx8s5q0n0s , |
unii-dx8s5q0n0s |
101155-02-6 |
S6576 |
DTXSID50143759 |
AKOS030562250 |
CS-0018097 |
HY-100118 |
bwa-78u |
A17098 |
BCP30171 |
bw a78u;bw-a 78u;bw-a78u |
9h-purin-6-amine, 9-[(2-fluorophenyl)methyl]-n-methyl- |
9-(2-fluorobenzyl)-n-methyl-9h-purin-6-amine |
MS-23624 |
EX-A3196 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (19)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID184623 | Compound was evaluated for the anticonvulsant activity in rats. | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | 9-(2-Fluorobenzyl)-6-(methylamino)-9H-purine hydrochloride. Synthesis and anticonvulsant activity. |
AID177407 | Compound was evaluated for the anticonvulsant activity by testing its ability to protect against maximal electroshock- induced seizures in rats; Intraperitoneal administration (ip) | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | 9-(2-Fluorobenzyl)-6-(methylamino)-9H-purine hydrochloride. Synthesis and anticonvulsant activity. |
AID25598 | Dissociation constant was measured | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18 | 8-Amino-3-benzyl-1,2,4-triazolo[4,3-a]pyrazines. Synthesis and anticonvulsant activity. |
AID180363 | The compound was tested for anticonvulsant activity against Maximal Electroshock-Induced Seizures(MES) in Wistar male rat, after peroral administration. | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18 | 8-Amino-3-benzyl-1,2,4-triazolo[4,3-a]pyrazines. Synthesis and anticonvulsant activity. |
AID19841 | Lipophilicity was measured | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18 | 8-Amino-3-benzyl-1,2,4-triazolo[4,3-a]pyrazines. Synthesis and anticonvulsant activity. |
AID180362 | The compound was tested for anticonvulsant activity against Maximal Electroshock-Induced Seizures(MES) in intraperitoneal administration. | 1995 | Journal of medicinal chemistry, Sep-01, Volume: 38, Issue:18 | 8-Amino-3-benzyl-1,2,4-triazolo[4,3-a]pyrazines. Synthesis and anticonvulsant activity. |
AID177270 | Compound was evaluated for the anticonvulsant activity by testing its ability to protect against maximal electroshock- induced seizures in rats after peroral administration (po) | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | 9-(2-Fluorobenzyl)-6-(methylamino)-9H-purine hydrochloride. Synthesis and anticonvulsant activity. |
AID26123 | pKa value of the compound | 1995 | Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19 | Synthesis and anticonvulsant activity of N-benzylpyrrolo[2,3-d]-, -pyrazolo[3,4-d]-, and -triazolo[4,5-d]pyrimidines: imidazole ring-modified analogues of 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine. |
AID180365 | The compound was tested for anticonvulsant activity against maximal electroshock-induced seizures after peroral administration in rats | 1995 | Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19 | Synthesis and anticonvulsant activity of N-benzylpyrrolo[2,3-d]-, -pyrazolo[3,4-d]-, and -triazolo[4,5-d]pyrimidines: imidazole ring-modified analogues of 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine. |
AID180364 | The compound was tested for anticonvulsant activity against maximal electroshock-induced seizures after intraperitoneal administration in rats | 1995 | Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19 | Synthesis and anticonvulsant activity of N-benzylpyrrolo[2,3-d]-, -pyrazolo[3,4-d]-, and -triazolo[4,5-d]pyrimidines: imidazole ring-modified analogues of 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine. |
AID178281 | Anticonvulsant activity against maximal electroshock-induced seizures in Wistar rats following i.p. administration. | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | 1-(Fluorobenzyl)-4-amino-1H-1,2,3-triazolo[4,5-c]pyridines: synthesis and anticonvulsant activity. |
AID113150 | Concentration required to protect 50 % of mice against hind limb extensor component in MES test when administered perorally | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | 9-(2-Fluorobenzyl)-6-(methylamino)-9H-purine hydrochloride. Synthesis and anticonvulsant activity. |
AID178283 | Anticonvulsant activity against maximal electroshock-induced seizures in rats after intraperitoneal administration. | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 9-(2-Fluorobenzyl)-6-(alkylamino)-9H-purines. A new class of anticonvulsant agents. |
AID178282 | Anticonvulsant activity against maximal electroshock-induced seizures in Wistar rats following p.o. administration. | 1995 | Journal of medicinal chemistry, Sep-29, Volume: 38, Issue:20 | 1-(Fluorobenzyl)-4-amino-1H-1,2,3-triazolo[4,5-c]pyridines: synthesis and anticonvulsant activity. |
AID113148 | Concentration required to protect 50 % of mice against hind limb extensor component in MES test when administered intraperitoneally | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | 9-(2-Fluorobenzyl)-6-(methylamino)-9H-purine hydrochloride. Synthesis and anticonvulsant activity. |
AID177408 | Compound was evaluated for the anticonvulsant activity by testing its ability to protect against maximal electroshock- induced seizures in rats; Intravenous administration (iv) | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | 9-(2-Fluorobenzyl)-6-(methylamino)-9H-purine hydrochloride. Synthesis and anticonvulsant activity. |
AID19691 | Partition coefficient (logP) | 1995 | Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19 | Synthesis and anticonvulsant activity of N-benzylpyrrolo[2,3-d]-, -pyrazolo[3,4-d]-, and -triazolo[4,5-d]pyrimidines: imidazole ring-modified analogues of 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine. |
AID178284 | Anticonvulsant activity against maximal electroshock-induced seizures in rats after oral administration | 1988 | Journal of medicinal chemistry, May, Volume: 31, Issue:5 | 9-(2-Fluorobenzyl)-6-(alkylamino)-9H-purines. A new class of anticonvulsant agents. |
AID113149 | Concentration required to protect 50 % of mice against hind limb extensor component in MES test when administered intravenously | 1986 | Journal of medicinal chemistry, Jul, Volume: 29, Issue:7 | 9-(2-Fluorobenzyl)-6-(methylamino)-9H-purine hydrochloride. Synthesis and anticonvulsant activity. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (8)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 2 (25.00) | 18.7374 |
1990's | 6 (75.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.56
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.56) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 8 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |