butobendin: RN refers to (S-(R*,R*))-isomer; Craviten is tradename; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Excerpt | Reference | Relevance |
|---|---|---|
| " Comparison of the decline of the same absolute and relative serum concentrations of the drug and the variation of pharmacokinetic parameters with the dose leads to the conclusion, that the elimination of Craviten in rats cannot be described by first-order kinetics." | ( Pharmacokinetic investigations of Craviten. II. Dose-dependent elimination kinetics in rats following rapid intravenous injection. Danek, A; Witek, J, ) | 0.13 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " To increase bioavailability in men the tablets or enteric coated tablets should be made according to the results of clinical trials." | ( In vitro study of (2S, 2'S) N,N'-dimethyl-N, N'-bis [1(3', 4', 5'-trimethoxybenzoyloxy) butyl-2] ethylenediamine salts and their bioavailability. Bartkowicz, S; Kluczykowska, B; Krówczyński, L; Stozek, T; Wajdowicz, A, ) | 0.13 |
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to improve the oral dosage form of the title compound." | ( In vitro study of (2S, 2'S) N,N'-dimethyl-N, N'-bis [1(3', 4', 5'-trimethoxybenzoyloxy) butyl-2] ethylenediamine salts and their bioavailability. Bartkowicz, S; Kluczykowska, B; Krówczyński, L; Stozek, T; Wajdowicz, A, ) | 0.13 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (7.14%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 1 (3.57%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 25 (89.29%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||