Compounds > bromantane
Page last updated: 2024-11-10

bromantane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

bromantane: a derivative of 2-aminoadamantane; a CNS stimulant [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID4660557
CHEMBL ID4303520
SCHEMBL ID737152
MeSH IDM0227950

Synonyms (29)

Synonym
n-(4-bromophenyl)adamantan-2-amine
n-(4-bromophenyl)-2-adamantanamine
A842407
AKOS004120981
2-bromophenyl-1-amino adamantane
bromontan
87913-26-6
bromantane
2-(4-bromophenyl)aminoadamantane
n-(2-adamantyl)-n-(4-bromophenyl)amine
bromantan
S10385
tricyclo[3.3.1.13,7]decan-2-amine,n-(4-bromophenyl)-
SCHEMBL737152
ladasten
N1ILS53XWK ,
bromantane [who-dd]
tricyclo(3.3.1.13,7)decan-2-amine, n-(4-bromophenyl)-
n-(4-bromophenyl)tricyclo(3.3.1.13,7)decan-2-amine
DTXSID40405333
unii-n1ils53xwk
n-(2-adamantyl)-n-(p-bromophenyl)-amine
AS-54469
Q385533
tricyclo[3.3.1.13,7]decan-2-amine, n-(4-bromophenyl)-
EN300-154642
CHEMBL4303520
AKOS037644786
Z440843598

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" It was established that catecholaminergic effects account for the mechanism of therapeutic action of bromantan, while cholinergic effects determine the drug action in toxic doses."( [An acute toxicity study of bromantane].
Bugaeva, LI; Iezhitsa, IN; Spasov, AA; Verovskiĭ, VE, )		0.43
"The experiments on rats showed for bemithyl LD50 = 581."( [Acute toxicity of bemithyl and bromithyl].
Bugaeva, LI; Iezhitsa, IN; Spasov, AA; Verovskiĭ, VE, )		0.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's9 (69.23)18.2507
2000's3 (23.08)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 53.71

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index53.71 (24.57)
Research Supply Index3.43 (2.92)
Research Growth Index4.20 (4.65)
Search Engine Demand Index116.94 (26.88)
Search Engine Supply Index2.77 (0.95)

This Compound (53.71)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other29 (96.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
amantadine
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source		5.04130adamantanes;
primary aliphatic amine		analgesic;
antiparkinson drug;
antiviral drug;
dopaminergic agent;
NMDA receptor antagonist;
non-narcotic analgesic
rimantadine
Rimantadine: An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.		1.9910alkylamine
3-hydroxypyridine
3-hydroxypyridine: RN given refeirs to parent cpd. 3-pyridinol : A monohydroxypyridine that is pyridine in which the hydrogen at position 3 has been replaced by a hydroxy group. It has been detected as a thermal degradation product from the smoke of the burning leaves of Salvia divinorum, a Mexican psychoactive plant.		2.0110monohydroxypyridine
adamantane
Adamantane: A tricyclo bridged hydrocarbon.		3.110adamantanes;
polycyclic alkane
2-aminoadamantane
2-aminoadamantane: inhibits lymphocyte proliferation; RN given refers to parent cpd		1.9810
adapromine
adapromine: RN given refers to parent cpd		6.9910
tetrodotoxin
Tetrodotoxin: An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.. tetrodotoxin : A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.		1.9810azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid		animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker
bemethyl
bemethyl: 2-mercaptobenzimidazole deriv.; alkylating agent and mutagen antagonist		2.9240
ConditionIndicatedRelationship StrengthStudiesTrials
Anoxemia
[description not available]		02.0810
Pyrexia
[description not available]		02.0810
Hypercapnia
A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.		02.0810
Hypothermia, Accidental
[description not available]		02.0810
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms.		02.0810
Fever
An abnormal elevation of body temperature, usually as a result of a pathologic process.		02.0810
Hypothermia
Lower than normal body temperature, especially in warm-blooded animals.		02.0810
Carbon Monoxide Poisoning
Toxic asphyxiation due to the displacement of oxygen from oxyhemoglobin by carbon monoxide.		01.9810