benz(l)aceanthrylene profile

Benz(l)aceanthrylene is a polycyclic aromatic hydrocarbon (PAH) that has been identified as a potent environmental carcinogen. It is found in various environmental sources, including coal tar, diesel exhaust, and tobacco smoke. Benz(l)aceanthrylene is primarily studied because of its carcinogenic effects and is a key target for environmental monitoring and pollution control strategies. The molecule exhibits significant mutagenic activity, inducing DNA damage and disrupting cellular processes. This compound is also of interest to researchers investigating the mechanisms of PAH carcinogenesis and the development of effective treatments and prevention strategies. Studies exploring the synthesis of benz(l)aceanthrylene involve various methodologies, including the cyclization reactions of aromatic precursors. Furthermore, research efforts are focused on developing methods for its detection and quantification in environmental samples to assess potential health risks.'

benz(l)aceanthrylene: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	105092
CHEBI ID	82396
MeSH ID	M0122282

Synonym
benz(1)aceanthrylene
benz(l)aceanthrylene
brn 2557841
ccris 2272
C19336
211-91-6
benz[l]aceanthrylene
unii-5gxm6n8uih
5gxm6n8uih ,
benz[l]aceanthrylene(8ci,9ci)
benz(l)aceanthrylene [iarc]
CHEBI:82396
DTXSID70175330
AKOS030254932
benz[1]aceanthrylene
Q27155919
pentacyclo[11.6.1.02,11.03,8.017,20]icosa-1(20),2(11),3,5,7,9,12,14,16,18-decaene
cyclopenta[no]tetraphene
STARBLD0027902

Class	Description
phenanthrenes	Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (55.56)	18.7374
1990's	4 (44.44)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
3-methylcholanthrene Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.. 3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.	3.08	5	ortho- and peri-fused polycyclic arene	aryl hydrocarbon receptor agonist; carcinogenic agent
benzo(a)pyrene Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.	2.67	3	ortho- and peri-fused polycyclic arene	carcinogenic agent; mouse metabolite
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	1.97	1	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
cyclopentane Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.	1.99	1	cycloalkane; cyclopentanes; volatile organic compound	non-polar solvent
chlorodiphenyl (54% chlorine) Chlorodiphenyl (54% Chlorine): A mixture of polychlorinated biphenyls that induces hepatic microsomal UDP-glucuronyl transferase activity towards thyroxine.. Aroclor 1254 : A mixture of polychlorobiphenyls of unspecified composition, containing 54% chlorine (X = Cl or H).	1.97	1
benz(j)aceanthrylene [no description available]	3.08	5	phenanthrenes
thioguanine anhydrous Thioguanine: An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.. tioguanine : A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia.	1.96	1	2-aminopurines	anticoronaviral agent; antimetabolite; antineoplastic agent
phosphorus radioisotopes Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.	1.99	1

Condition	Relationship Strength	Studies
Papilloma, Squamous Cell [description not available]	1.96	1
Cancer of Skin [description not available]	1.96	1
Papilloma A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)	1.96	1
Skin Neoplasms Tumors or cancer of the SKIN.	1.96	1
Abnormalities, Autosome [description not available]	1.96	1
Leukemia L5178 An experimental lymphocytic leukemia of mice.	1.96	1

benz(l)aceanthrylene

Description

Cross-References

Synonyms (19)

Drug Classes (1)

Research

Studies (9)

Study Types