Compounds > aschantin
Page last updated: 2024-12-07

aschantin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

aschantin: from flower buds of Magnolia fargesii; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
MagnoliagenusA plant genus of the family MAGNOLIACEAE. The germacranolide sesquiterpene lactones costunolide, parthenolide, and costunolide diepoxide have been isolated from the leaves. Bark contains honokiol and magnolol. Parts are an ingredient of Banxia Houpo Tang.[MeSH]MagnoliaceaeA plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. They are trees and shrubs having an elongated conelike floral axis with fragrant flowers that have six tepals (sepals and petals that are not distinctly different) and many spirally arranged stamens.[MeSH]

Cross-References

ID SourceID
PubMed CID122643
SCHEMBL ID17969446
MeSH IDM0547583

Synonyms (15)

Synonym
ACON1_000607
(+)-aschantin
13060-15-6
5-[(3s,3ar,6s,6ar)-6-(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-1,3-benzodioxole
1,3-benzodioxole, 5-[tetrahydro-4-(3,4,5-trimethoxyphenyl)-1h,3h-furo[3,4-c]furan-1-yl]-, (1s,3ar,4s,6ar)-
aschantin
MEGXP0_000713
NCGC00168917-01
BRD-K09922030-001-01-3
C17845
1,3-benzodioxole, 5-(tetrahydro-4-(3,4,5-(trimethoxyphenyl)-1h,3h-furo(3,4-c)furan-1-yl))-, (1s-(1alpha,3aalpha,4alpha,6aalpha))-
5-(tetrahydro-4-(3,4,5-(trimethoxyphenyl)-1h,3h-furo(3,4-c)furan-1-yl))-1,3-benzodioxole (1s-(1alpha,3aalpha,4alpha,6aalpha))-
DTXSID00156632
SCHEMBL17969446
AKOS040736022

Research Excerpts

Overview

Aschantin is a bioactive neolignan found in Magnolia flos. It has antiplasmodial, Ca(2+)-antagonistic, platelet activating factor-antagonism, and chemopreventive activities.

ExcerptReferenceRelevance
"Aschantin is a bioactive neolignan found in Magnolia flos with antiplasmodial, Ca(2+)-antagonistic, platelet activating factor-antagonistic, and chemopreventive activities. "( Inhibitory Effects of Aschantin on Cytochrome P450 and Uridine 5'-diphospho-glucuronosyltransferase Enzyme Activities in Human Liver Microsomes.
Cho, YY; Jeong, HU; Kim, JH; Kwon, SS; Lee, HS; Oh, SR, 2016)		2.19
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.91

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.91 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.91)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
theophylline
[no description available]		2.2510dimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent
planinin
planinin: from Zanthoxylum planispinum; structure given in first source		2.0510lignan
kobusin
kobusin: from flower buds of Magnolia fargesii; structure in first source. demethoxyaschantin : A member of the class of furofurans that is tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole carrying an additional 3,4-dimethoxyphenyl substituent at position 4.		2.0510benzodioxoles;
dimethoxybenzene;
furofuran;
lignan		plant metabolite
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		3.2250
epidermal growth factor
Epidermal Growth Factor: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.		7.1110
ConditionIndicatedRelationship StrengthStudiesTrials
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.		02.1110