Compounds > af 150
Page last updated: 2024-11-12

af 150

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-methylpiperidine-4-spiro-(2'-methylthiazoline): a selective and efficacious M1 agonist no further information [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10176415
SCHEMBL ID1328277
MeSH IDM0179184

Synonyms (11)

Synonym
1-thia-3,8-diazaspiro(4.5)dec-2-ene, 2,8-dimethyl-
138300-72-8
af-150(s)
af 150(s)
1-methylpiperidine-4-spiro-(2'-methylthiazoline)
2,8-dimethyl-1-thia-3,8-diazaspiro[4.5]dec-2-ene
L007073
SCHEMBL1328277
2,8-dimethyl-1-thia-3,8-diaza-spiro[4.5]dec-2-ene
af150(s)
VGGGBQVTSUMURJ-UHFFFAOYSA-N

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" Notably, these compounds show a high bioavailability and a remarkable preference for the brain vs."( AF150(S) and AF267B: M1 muscarinic agonists as innovative therapies for Alzheimer's disease.
Bar-Ner, RH; Brandeis, R; Fisher, A; Kliger-Spatz, M; Marcovitch, I; Natan, N; Pittel, Z; Sonego, H, )		0.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (50.00)18.2507
2000's3 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 60.22

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index60.22 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.25 (4.65)
Search Engine Demand Index94.49 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (60.22)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (25.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (75.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		3.110amino-acid anion
quinuclidines
Quinuclidines: A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms and contains an amine group.		3.5120quinuclidines;
saturated organic heterobicyclic parent
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		3.5120mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
thiazoles
[no description available]		4.86601,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
rivastigmine
[no description available]		3.110carbamate ester;
tertiary amino compound		cholinergic drug;
EC 3.1.1.8 (cholinesterase) inhibitor;
neuroprotective agent
piperidines
Piperidines: A family of hexahydropyridines.		4.8660
amyloid beta-peptides
amyloid beta-protein (1-40): although acutely neurotoxic in both rat & monkey cerebral cortex, neuronal degeneration in primates resembles more closely to that found in Alzheimer's disease; amino acid sequence has been determined		210
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Confusional Senile Dementia
[description not available]		04.0830
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		03.820
Age-Related Memory Disorders
[description not available]		02.9310
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)		04.0830
Memory Disorders
Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.		02.9310
Cognition Disorders
Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.		01.9910
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		0210