Page last updated: 2024-11-07

5-benzyloxybenzylacyclouridine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

5-benzyloxybenzylacyclouridine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

5-benzyloxybenzylacyclouridine : A benzyl ether that consists of acyclouridine bearing a 3-(benzyloxy)benzyl substituent at position 5. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID134111
CHEMBL ID277577
CHEBI ID39579
SCHEMBL ID21067979
MeSH IDM0106898

Synonyms (22)

Synonym
5-[3-(benzyloxy)benzyl]-1-[(2-hydroxyethoxy)methyl]pyrimidine-2,4(1h,3h)-dione
5-(3-benzyloxy-benzyl)-1-(2-hydroxy-ethoxymethyl)-1h-pyrimidine-2,4-dione
bdbm50030980
5-bbau
2,4(1h,3h)-pyrimidinedione, 1-((2-hydroxyethyoxy)methyl)-5-((3-(phenylmethoxy)phenyl)methyl)-
2,4(1h,3h)-pyrimidinedione, 1-((2-hydroxyethoxy)methyl)-5-((3-(phenylmethoxy)phenyl)methyl)-
unii-ta375l4wsv
5-(m-benzyloxybenzyl)-1-(2'-hydroxyethoxymethyl)uracil
ta375l4wsv ,
1-((2-hydroxyethoxy)methyl)-5-(3-(benzyloxy)benzyl)pyrimidine-2,4(1h,3h)-dione
5-benzyloxybenzylacyclouridine
DB06873
CHEMBL277577 ,
chebi:39579 ,
82857-75-8
5-(benzyloxybenzyl)acyclouridine
bbau
Q27095778
SCHEMBL21067979
5-{[3-(benzyloxy)phenyl]methyl}-4-hydroxy-1-[(2-hydroxyethoxy)methyl]pyrimidin-2(1h)-one
DTXSID201002966
PD005825
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
primary alcoholA primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.
benzyl etherA compound of formula PhCH2OR (R =/= H).
hydroxyetherAny ether carrying a hydroxy group at unspecified position.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Uridine phosphorylase 1Mus musculus (house mouse)IC50 (µMol)0.08400.08402.08135.7000AID215632
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID215630Tested for inhibition of Uridine Phosphorylase (UrdPase) in murine liver1997Journal of medicinal chemistry, Apr-11, Volume: 40, Issue:8
Inhibition of uridine phosphorylase. Synthesis and structure-activity relationships of aryl-substituted 1-((2-hydroxyethoxy)methyl)-5-(3-phenoxybenzyl)uracil.
AID215632Inhibition of uridine phosphorylase (UrdPase) from murine liver.1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Inhibition of uridine phosphorylase: synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.60

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.60 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.39 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.60)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]