1-alpha, 25-difluorovitamin d3 profile

1-alpha, 25-dihydroxyvitamin D3, also known as **calcitriol**, is the **active form of vitamin D** in the body. It plays a crucial role in **calcium and phosphorus metabolism**, which are essential for maintaining bone health, muscle function, and overall health.

**Here's why it's important for research:**

* **Bone Health:** Calcitriol promotes calcium absorption in the gut and helps maintain bone density. Research on calcitriol focuses on understanding its role in preventing and treating osteoporosis, rickets, and other bone diseases.
* **Immune Function:** Calcitriol has been shown to modulate immune responses and may be involved in regulating autoimmune diseases. Research is exploring its potential therapeutic applications in inflammatory conditions.
* **Cancer Prevention:** Some studies suggest that calcitriol may have anti-cancer properties and may help prevent the development of certain types of cancer. This area of research is still ongoing.
* **Cardiovascular Health:** Calcitriol may play a role in regulating blood pressure and reducing the risk of cardiovascular disease. Research is exploring its potential benefits in preventing heart attacks and strokes.
* **Mental Health:** Emerging research indicates that calcitriol may be linked to mood regulation and could have implications for treating depression and other mental health conditions.

**Research on calcitriol is vital for:**

* **Understanding the complex mechanisms** by which it regulates various bodily functions.
* **Developing new therapies** to treat diseases associated with vitamin D deficiency, such as osteoporosis, rickets, and some autoimmune disorders.
* **Investigating its potential role** in the prevention and treatment of other diseases, such as cancer and cardiovascular disease.

**Key points about calcitriol research:**

* **It is a rapidly evolving field** with new discoveries constantly being made.
* **Ethical considerations** are important, as high doses of calcitriol can have adverse effects.
* **Further research** is needed to fully understand its role in human health and to develop safe and effective therapies.

ID Source	ID
PubMed CID	6444057
MeSH ID	M0098373

Synonym
1-alpha, 25-difluorovitamin d3
(1s,3z,5r)-3-[(2e)-2-[(1r,3as,7ar)-1-[(2r)-6-fluoro-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-5-fluoro-4-methylidenecyclohexan-1-ol
9,10-secocholesta-5,7,10(19)-trien-3-ol, 1,25-difluoro-, (1alpha,3beta,5z,7e)-
78609-64-0

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (20.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
telmisartan Telmisartan: A biphenyl compound and benzimidazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION.. telmisartan : A member of the class of benzimidazoles used widely in the treatment of hypertension.	2.21	1	benzimidazoles; biphenyls; carboxybiphenyl	angiotensin receptor antagonist; antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; environmental contaminant; xenobiotic
cholecalciferol Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.. calciol : A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.	1.96	1	D3 vitamins; hydroxy seco-steroid; seco-cholestane; secondary alcohol; steroid hormone	geroprotector; human metabolite
fumarates Fumarates: Compounds based on fumaric acid.. fumarate(2-) : A C4-dicarboxylate that is the E-isomer of but-2-enedioate(2-)	2.21	1	butenedioate; C4-dicarboxylate	human metabolite; metabolite; Saccharomyces cerevisiae metabolite
aliskiren aliskiren: orally active nonpeptidic renin inhibitor. aliskiren : A monomethoxybenzene compound having a 3-methoxypropoxy group at the 2-position and a multi-substituted branched alkyl substituent at the 4-position.	2.21	1	monocarboxylic acid amide; monomethoxybenzene	antihypertensive agent
losartan potassium Erythropoietin: Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.	2.02	1

Condition	Relationship Strength	Studies
Acute Confusional Senile Dementia [description not available]	2.15	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.15	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.1	1
Endometrioma An enlarged area of ENDOMETRIOSIS that resembles a tumor. It is usually found in the OVARY. When it is filled with old blood, it is known as a chocolate cyst.	2.1	1
Angiogenesis, Pathologic [description not available]	2.1	1
Endometriosis A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.	2.1	1
Chronic Kidney Failure [description not available]	2.02	1
Anemia A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.	2.02	1
Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.	2.02	1

1-alpha, 25-difluorovitamin d3

Cross-References

Synonyms (4)

Research

Studies (5)

Market Indicators

Research Demand Index: 13.01

Study Types