histone H3K56 methyltransferase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 56) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 56). This reaction is the addition of a methyl group to the lysine residue at position 56 of the histone H3 protein. [PMID:23451023, PMID:28743002]

Histone H3K56 methyltransferase activity refers to the enzymatic process by which a methyl group is transferred from a methyl donor, such as S-adenosyl methionine (SAM), to the lysine residue at position 56 (K56) on histone H3. This methylation event is a crucial epigenetic modification that plays a vital role in regulating various cellular processes, including DNA replication, DNA repair, and gene expression. Histone H3K56 methylation is catalyzed by specific enzymes known as histone H3K56 methyltransferases, which exhibit distinct substrate specificities and regulatory mechanisms. The molecular function of histone H3K56 methyltransferase activity involves a complex interplay of protein-protein interactions, substrate recognition, and enzymatic catalysis. It begins with the recruitment of the enzyme to the chromatin by specific protein interactions or DNA sequence elements. Once bound to the chromatin, the enzyme recognizes the histone H3 substrate through its unique amino acid sequence and structural features. This recognition process is often facilitated by specific histone modifications or other chromatin-associated proteins. Subsequently, the enzyme catalyzes the transfer of a methyl group from SAM to the ε-amino group of lysine 56 on histone H3, utilizing a complex catalytic mechanism that involves cofactor binding, substrate binding, and methyl group transfer. The resulting methylation modification at H3K56 alters the local chromatin structure, impacting the accessibility of DNA to regulatory proteins and modulating gene expression. The precise impact of H3K56 methylation on gene regulation depends on the specific genomic context and the interplay with other epigenetic modifications. Overall, histone H3K56 methyltransferase activity represents a fundamental epigenetic regulatory mechanism that contributes to the complex and dynamic control of cellular processes, playing a crucial role in maintaining genomic integrity and shaping cellular identity.'
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Proteins (1)

Compounds (32)