pyrimidine- and adenosine-specific:sodium symporter activity

Definition

Target type: molecularfunction

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenosine)(out) + Na+(out) = (pyrimidine nucleoside or adenosine)(in) + Na+(in). [TC:2.A.41.2.3]

Pyrimidine- and adenosine-specific:sodium symporter activity is a molecular function that describes the ability of a protein to transport both pyrimidine nucleobases (like cytosine, thymine, and uracil) and adenosine, a purine nucleoside, across a cell membrane. This transport is coupled to the movement of sodium ions (Na+) down their electrochemical gradient, which provides the energy for the transport of the nucleobases and adenosine against their concentration gradient. This type of symport mechanism is essential for the uptake of these molecules into cells, where they are used for various cellular processes such as DNA and RNA synthesis, protein synthesis, and energy production. The symporter protein typically binds both the pyrimidine/adenosine and Na+ ions simultaneously, facilitating their coordinated movement across the membrane. This process is highly specific, ensuring that only the target molecules are transported while other molecules are excluded. The symporter protein may be involved in different cellular processes, such as nutrient uptake, signal transduction, and maintaining intracellular ion homeostasis. Dysregulation of this activity can lead to various cellular dysfunction and diseases.'
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Proteins (4)

Compounds (26)