Page last updated: 2024-09-03

mk 0663 and aspirin

mk 0663 has been researched along with aspirin in 22 studies

Compound Research Comparison

Studies
(mk 0663)
Trials
(mk 0663)
Recent Studies (post-2010)
(mk 0663)
Studies
(aspirin)
Trials
(aspirin)
Recent Studies (post-2010) (aspirin)
54917326548,9476,81713,778

Protein Interaction Comparison

ProteinTaxonomymk 0663 (IC50)aspirin (IC50)
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.35
Integrin beta-3Homo sapiens (human)5
Prostaglandin G/H synthase 1Ovis aries (sheep)0.8252
Seed linoleate 13S-lipoxygenase-1Glycine max (soybean)1.375
Integrin alpha-IIbHomo sapiens (human)5
Prostaglandin G/H synthase 1Homo sapiens (human)2.271
Substance-P receptorCavia porcellus (domestic guinea pig)2.4
Prostaglandin G/H synthase 2Homo sapiens (human)2.15
Urotensin-2 receptorRattus norvegicus (Norway rat)0.3
4-aminobutyrate aminotransferase, mitochondrialRattus norvegicus (Norway rat)2.4
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.35
Prostaglandin G/H synthase 2Ovis aries (sheep)2.4081

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (54.55)29.6817
2010's10 (45.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Ouellet, M; Percival, MD; Riendeau, D1
Choi, YS; Kim, JA; Kim, SH1
Al-Herz, AA; Al-Qhouti, BI; Khadadah, ME; Muqim, AT; Nahar, IK; Shehab, DK; Uppal, SS1
Bolognese, JA; Cannon, CP; Curtis, SP; Laine, L1
Ahmed, I; El Gaafary, M; El Miedany, Y; Youssef, S1
Hilário, MO; Len, CA; Terreri, MT1
Cannon, CP; Cryer, B; Curtis, SP; Kaur, A; Laine, L1
Calcagnile, F; Calogiuri, G; Ferrannini, A; Muratore, L; Muratore, M; Quarta, E; Ventura, M1
Bernardi, RM; Dalmora, SL; Ferretto, RM; Fronza, M; Sangoi, MS; Wrasse, M1
Cardoso, C; Hoffken, G; Koschel, D; Leucht, V1
Ciabattoni, G; Davì, G; Dragani, A; Ferrante, E; Habib, A; Lattanzio, S; Mattoscio, D; Mucci, L; Pascale, S; Patrono, C; Petrucci, G; Ranelletti, FO; Recchiuti, A; Rocca, B1
Soares, J1
Becker, V; Bulut, D; Mügge, A1
Blanca, M; Blanca-López, N; Campo, P; Canto, G; Doña, I; Fernández, J; Gómez, AI; Jagemann, LR; Laguna, JJ; Rondón, C; Rosado, A; Torres, MJ1
Calvello, R; Carbone, ML; Cianciulli, A; Malerba, P; Panaro, MA; Perrone, MG; Scilimati, A; Vitale, P1
Adami, S; Gatti, D1
Kasemier, J; Meek, IL; Movig, KL; van de Laar, MA; Vonkeman, HE1
Helmchen, C; Hertel, S; Schwaninger, M1
Baglie, S; Baller, EM; Franco, GC; Gevert, MV; Lupepsa, AC; Moro, MG; Sanchez, PK; Tostes, AF1

Reviews

3 review(s) available for mk 0663 and aspirin

ArticleYear
Nonsteroidal anti-inflammatory drugs: cyclooxygenase 2 inhibitors.
    Jornal de pediatria, 2006, Volume: 82, Issue:5 Suppl

    Topics: Adolescent; Aspirin; Celecoxib; Child; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Interactions; Etoricoxib; Fever; Humans; Hypersensitivity, Immediate; Inflammation; Leukotrienes; Meloxicam; Naproxen; Pain; Prostaglandins; Pyrazoles; Pyridines; Sulfonamides; Sulfones; Thiazines; Thiazoles; Treatment Outcome

2006
Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison.
    Lancet (London, England), 2007, Feb-10, Volume: 369, Issue:9560

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Etoricoxib; Female; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Osteoarthritis; Peptic Ulcer; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Pyridines; Sulfones

2007
Coxibs: a significant therapeutic opportunity.
    Acta bio-medica : Atenei Parmensis, 2010, Volume: 81, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2 Inhibitors; Drug Interactions; Etoricoxib; Gastrointestinal Tract; Humans; Osteoarthritis; Pain Measurement; Pyridines; Spondylitis, Ankylosing; Sulfones

2010

Trials

6 trial(s) available for mk 0663 and aspirin

ArticleYear
The use of etoricoxib in patients with bronchial asthma associated with aspirin sensitivity.
    Saudi medical journal, 2006, Volume: 27, Issue:1

    Topics: Aspirin; Asthma; Cyclooxygenase Inhibitors; Drug Hypersensitivity; Etoricoxib; Humans; Pyridines; Sulfones

2006
Safety of etoricoxib, a specific cyclooxygenase-2 inhibitor, in asthmatic patients with aspirin-exacerbated respiratory disease.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2006, Volume: 97, Issue:1

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Bronchial Provocation Tests; Cross Reactions; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Dyspnea; Etoricoxib; Female; Forced Expiratory Volume; Humans; Male; Peak Expiratory Flow Rate; Pyridines; Rheumatic Diseases; Single-Blind Method; Sulfones

2006
Tolerance to etoricoxib in 37 patients with urticaria and angioedema induced by nonsteroidal anti-inflammatory drugs.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2007, Volume: 98, Issue:2

    Topics: Adult; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Pressure; Cyclooxygenase 2 Inhibitors; Drug Hypersensitivity; Etoricoxib; Female; Humans; Male; Middle Aged; Peak Expiratory Flow Rate; Pyridines; Sulfones; Urticaria

2007
The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy.
    Blood, 2010, Feb-04, Volume: 115, Issue:5

    Topics: Adult; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Etoricoxib; Female; Humans; Immunohistochemistry; Male; Middle Aged; Platelet Aggregation Inhibitors; Pyridines; Sulfones; Thrombocythemia, Essential; Thromboxane A2; Thromboxane B2; Thromboxanes; Treatment Outcome

2010
Response to a selective COX-2 inhibitor in patients with urticaria/angioedema induced by nonsteroidal anti-inflammatory drugs.
    Allergy, 2011, Volume: 66, Issue:11

    Topics: Acetaminophen; Adolescent; Adult; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2 Inhibitors; Drug Hypersensitivity; Etoricoxib; Humans; Hypersensitivity, Immediate; Ibuprofen; Pyridines; Single-Blind Method; Sulfones; Urticaria; Young Adult

2011
Interference of NSAIDs with the thrombocyte inhibitory effect of aspirin: a placebo-controlled, ex vivo, serial placebo-controlled serial crossover study.
    European journal of clinical pharmacology, 2013, Volume: 69, Issue:3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Administration Schedule; Drug Interactions; Etoricoxib; Female; Humans; Ibuprofen; Male; Meloxicam; Middle Aged; Naproxen; Netherlands; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Pyridines; Risk Assessment; Sulfones; Thiazines; Thiazoles; Time Factors; Young Adult

2013

Other Studies

13 other study(ies) available for mk 0663 and aspirin

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirin.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Dec-04, Volume: 98, Issue:25

    Topics: Acetylation; Animals; Aspirin; Blood Platelets; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etoricoxib; Humans; Ibuprofen; In Vitro Techniques; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Sheep; Sulfonamides; Sulfones

2001
Adverse effects of etoricoxib: other considerations.
    Mayo Clinic proceedings, 2005, Volume: 80, Issue:9

    Topics: Aspirin; Cardiovascular Diseases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etoricoxib; Gastrointestinal Diseases; Humans; Osteoarthritis; Pyridines; Sulfones

2005
Clinical trial design and patient demographics of the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) study program: cardiovascular outcomes with etoricoxib versus diclofenac in patients with osteoarthritis and rheumatoid arthritis.
    American heart journal, 2006, Volume: 152, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Etoricoxib; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Osteoarthritis; Patient Selection; Pyridines; Randomized Controlled Trials as Topic; Research Design; Risk Assessment; Sulfones; Treatment Outcome

2006
Evaluation of the changes in hemostatic parameters induced by etoricoxib in rat model.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2008, Volume: 19, Issue:3

    Topics: Animals; Aspirin; Blood Coagulation Tests; Cyclooxygenase Inhibitors; Disease Models, Animal; Etoricoxib; Factor Xa; Hemostasis; Male; Prothrombin; Pyridines; Rats; Sulfones

2008
Asthmatic reaction induced by Etoricoxib in a patient with aspirin-sensitive asthma.
    Allergy, 2008, Volume: 63, Issue:8

    Topics: Anaphylaxis; Aspirin; Asthma; Cyclooxygenase Inhibitors; Etoricoxib; Female; Humans; Middle Aged; Pyridines; Severity of Illness Index; Sulfones

2008
Low-dose aspirin reduces gastro-protective properties of COX-2 selective inhibitors.
    Clinical drug investigation, 2009, Volume: 29 Suppl 2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cyclooxygenase 2 Inhibitors; Drug Interactions; Duodenal Ulcer; Etoricoxib; Female; Humans; Middle Aged; Pantoprazole; Peptic Ulcer Hemorrhage; Pyridines; Sulfones

2009
Acetylsalicylate reduces endothelial and platelet-derived microparticles in patients with coronary artery disease.
    Canadian journal of physiology and pharmacology, 2011, Volume: 89, Issue:4

    Topics: Aspirin; Blood Platelets; Cell-Derived Microparticles; Coronary Artery Disease; Cyclooxygenase 2 Inhibitors; Endothelial Cells; Endothelium, Vascular; Etoricoxib; Humans; Male; Middle Aged; Pyridines; Stem Cells; Sulfones; Vasodilation

2011
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells.
    Pharmacological research, 2012, Volume: 65, Issue:1

    Topics: Animals; Aspirin; Celecoxib; Cell Line; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Etoricoxib; I-kappa B Proteins; Inflammation Mediators; Intramolecular Oxidoreductases; Lipopolysaccharides; Membrane Proteins; Mice; Microglia; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type II; Phosphorylation; Prostaglandin-E Synthases; Pyrazoles; Pyridines; RNA, Messenger; Sulfonamides; Sulfones

2012
Combined toxicity of penicillin and aspirin therapy may elicit bilateral vestibulopathy.
    Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:7

    Topics: Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Electronystagmography; Etoricoxib; Female; Gait Disorders, Neurologic; Humans; Male; Neurologic Examination; Penicillins; Pyridines; Reflex, Vestibulo-Ocular; Sulfones; Vestibular Diseases; Vestibular Evoked Myogenic Potentials; Vestibular Function Tests

2013
Gastric and renal effects of COX-2 selective and non-selective NSAIDs in rats receiving low-dose aspirin therapy.
    Brazilian oral research, 2016, Nov-28, Volume: 30, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Creatinine; Cyclooxygenase 2 Inhibitors; Etoricoxib; Gastric Mucosa; Ibuprofen; Kidney; Kidney Diseases; Male; Platelet Aggregation Inhibitors; Pyridines; Random Allocation; Rats, Wistar; Risk Factors; Stomach Diseases; Sulfones; Time Factors; Treatment Outcome

2016