l 740093 and l 365260
l 740093 has been researched along with l 365260 in 7 studies
Compound Research Comparison
| Studies (l 740093) | Trials (l 740093) | Recent Studies (post-2010) (l 740093) | Studies (l 365260) | Trials (l 365260) | Recent Studies (post-2010) (l 365260) |
|---|---|---|---|---|---|
| 16 | 0 | 0 | 422 | 10 | 8 |
Protein Interaction Comparison
| Protein | Taxonomy | l 740093 (IC50) | l 365260 (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0081 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0081 | |
| Cholecystokinin receptor type A | Rattus norvegicus (Norway rat) | 0.4981 | |
| Gastrin/cholecystokinin type B receptor | Rattus norvegicus (Norway rat) | 0.039 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.0081 | |
| Histamine H1 receptor | Cavia porcellus (domestic guinea pig) | 5 | |
| Cholecystokinin receptor type A | Homo sapiens (human) | 0.1585 | |
| Gastrin/cholecystokinin type B receptor | Homo sapiens (human) | 0.0079 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 5 | |
| Cholecystokinin receptor type A | Cavia porcellus (domestic guinea pig) | 0.044 | |
| Cysteinyl leukotriene receptor 2 | Homo sapiens (human) | 5 | |
| Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | 5 |
Research
Studies (7)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Ball, RG; Broughton, HB; Castro, JL; Chapman, KL; Marshall, GR; Matassa, VG; Patel, S; Rathbone, D; Russell, MG; Smith, AJ; Watt, AP | 1 |
| Chapman, KL; Fletcher, AE; Hargreaves, RJ; Iversen, LL; Iversen, SD; Kemp, JA; Marshall, GR; Patel, S; Ryecroft, W; Smith, AJ | 1 |
| Ding, XQ; Håkanson, R | 1 |
| Beinborn, M; Kopin, AS; Quinn, SM | 1 |
| Dunlop, J | 1 |
| Beinborn, M; Bläker, M; Gordon, MC; Hsu, JE; Kopin, AS; Ren, Y | 1 |
| Ellnebo-Svedlund, K; Monstein, HJ; Nilsson, I; Svensson, SP | 1 |
Reviews
1 review(s) available for l 740093 and l 365260
| Article | Year |
|---|---|
CCK receptor antagonists.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cells, Cultured; Humans; Phenylurea Compounds; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin | 1998 |
Other Studies
6 other study(ies) available for l 740093 and l 365260
| Article | Year |
|---|---|
5-(Piperidin-2-yl)- and 5-(homopiperidin-2-yl)-1,4-benzodiazepines: high-affinity, basic ligands for the cholecystokinin-B receptor.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Drug Design; Guinea Pigs; Ligands; Models, Molecular; Phenylurea Compounds; Piperidines; Rats; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Structure-Activity Relationship | 1997 |
Biological properties of the benzodiazepine amidine derivative L-740,093, a cholecystokinin-B/gastrin receptor antagonist with high affinity in vitro and high potency in vivo.
Topics: Animals; Benzodiazepinones; Brain; Female; Gastric Acid; Guinea Pigs; In Vitro Techniques; Male; Mice; Pentagastrin; Phenylurea Compounds; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin | 1994 |
Evaluation of the specificity and potency of a series of cholecystokinin-B/gastrin receptor antagonists in vivo.
Topics: Analysis of Variance; Animals; Anti-Ulcer Agents; Benzodiazepines; Benzodiazepinones; Dose-Response Relationship, Drug; Female; Gastric Emptying; Gastric Mucosa; Histidine Decarboxylase; Hormone Antagonists; Infusions, Intravenous; Lethal Dose 50; Male; Mice; Phenylurea Compounds; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Structure-Activity Relationship | 1996 |
Minor modifications of a cholecystokinin-B/gastrin receptor non-peptide antagonist confer a broad spectrum of functional properties.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding, Competitive; COS Cells; Hormone Antagonists; Inositol Phosphates; Molecular Structure; Mutation; Peptides; Phenylurea Compounds; Receptors, Cholecystokinin; Signal Transduction; Transfection | 1998 |
Mutations within the cholecystokinin-B/gastrin receptor ligand 'pocket' interconvert the functions of nonpeptide agonists and antagonists.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Cell Membrane; COS Cells; DNA, Complementary; Hormone Antagonists; Humans; Inositol Phosphates; Iodine Radioisotopes; Ligands; Mutagenesis, Site-Directed; Mutation; Phenylurea Compounds; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide | 1998 |
Cloning and characterization of 5'-end alternatively spliced human cholecystokinin-B receptor mRNAs.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Benzodiazepinones; Binding, Competitive; Cholecystokinin; Cloning, Molecular; COS Cells; Gastrins; Humans; Molecular Sequence Data; Phenylurea Compounds; Protein Binding; Protein Biosynthesis; Receptors, Cholecystokinin; RNA, Messenger; Sequence Analysis, DNA; Transfection | 1998 |