kc 764 and aspirin
kc 764 has been researched along with aspirin in 3 studies
*Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) [MeSH]
*Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) [MeSH]
Compound Research Comparison
| Studies (kc 764) | Trials (kc 764) | Recent Studies (post-2010) (kc 764) | Studies (aspirin) | Trials (aspirin) | Recent Studies (post-2010) (aspirin) |
|---|---|---|---|---|---|
| 9 | 1 | 0 | 48,947 | 6,817 | 13,778 |
Protein Interaction Comparison
| Protein | Taxonomy | kc 764 (IC50) | aspirin (IC50) |
|---|---|---|---|
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | 0.35 | |
| Integrin beta-3 | Homo sapiens (human) | 5 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 0.8252 | |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | 1.375 | |
| Integrin alpha-IIb | Homo sapiens (human) | 5 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 2.271 | |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | 2.4 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 2.15 | |
| Urotensin-2 receptor | Rattus norvegicus (Norway rat) | 0.3 | |
| 4-aminobutyrate aminotransferase, mitochondrial | Rattus norvegicus (Norway rat) | 2.4 | |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | 0.35 | |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | 2.4081 |
Research
Studies (3)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Imai, S; Ino, T; Mitsuoka, Y; Momo, K; Nakamura, K; Ohkubo, H; Someya, K; Tachiiri, T | 1 |
| Ohkubo, H; Ohmuro, S; Taga, F; Tsukada, Y; Uchida, H | 1 |
| Ohkubo, H; Ohmuro, S; Sasahara, T; Taga, F; Uchida, H | 1 |
Other Studies
3 other study(ies) available for kc 764 and aspirin
| Article | Year |
|---|---|
Effects of the new antiplatelet agent 2-methyl-3-(1,4,5,6-tetrahydronicotinoyl)pyrazolo[1,5-a]pyridine on platelet aggregation and thrombosis in experimental animals.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Bridged Bicyclo Compounds; Cyclooxygenase Inhibitors; Dogs; Electroencephalography; Female; Fibrinolytic Agents; Guinea Pigs; Humans; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred ICR; Nicotinic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Inbred Strains; Respiration; Stomach Ulcer | 1992 |
Protective effect of the new antiplatelet agent 2-methyl-3-(1,4,5,6-tetrahydronicotinoyl)pyrazolo[1,5-a]pyridine on myocardial damage due to coronary occlusion and reperfusion in rabbit.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspartate Aminotransferases; Aspirin; Bridged Bicyclo Compounds; Chemotaxis, Leukocyte; Creatine Kinase; Guinea Pigs; L-Lactate Dehydrogenase; Male; Myocardial Infarction; Myocardial Reperfusion Injury; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nicotinic Acids; Platelet Aggregation Inhibitors; Rabbits; Thromboxane B2 | 1992 |
Antiplatelet effects of 2-methyl-3-(1,4,5,6-tetrahydronicotinoyl)pyrazolo[1,5-a]pyridine in relation to its disposition in rats, rabbits and dogs.
Topics: Animals; Aspirin; Bridged Bicyclo Compounds; Dogs; Epoprostenol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicotinic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Thromboxane A2; Tissue Distribution | 1992 |