aspalatone and aspirin
aspalatone has been researched along with aspirin in 7 studies
*Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) [MeSH]
*Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) [MeSH]
Compound Research Comparison
| Studies (aspalatone) | Trials (aspalatone) | Recent Studies (post-2010) (aspalatone) | Studies (aspirin) | Trials (aspirin) | Recent Studies (post-2010) (aspirin) |
|---|---|---|---|---|---|
| 7 | 0 | 1 | 48,947 | 6,817 | 13,778 |
Protein Interaction Comparison
| Protein | Taxonomy | aspalatone (IC50) | aspirin (IC50) |
|---|---|---|---|
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | 0.35 | |
| Integrin beta-3 | Homo sapiens (human) | 5 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 0.8252 | |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | 1.375 | |
| Integrin alpha-IIb | Homo sapiens (human) | 5 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 2.271 | |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | 2.4 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 2.15 | |
| Urotensin-2 receptor | Rattus norvegicus (Norway rat) | 0.3 | |
| 4-aminobutyrate aminotransferase, mitochondrial | Rattus norvegicus (Norway rat) | 2.4 | |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | 0.35 | |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | 2.4081 |
Research
Studies (7)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Han, BH; Kang, YH; Kim, YC; Park, YH; Suh, DY; Yang, HO | 1 |
| Han, BH; Kim, YC; Suh, DY; Yang, HO | 1 |
| Choi, DY; Choi, JH; Jhoo, WK; Kim, C; Kim, HC; Nam, SW; Park, ES | 1 |
| Han, BH; Kang, YH; Suh, DY | 1 |
| Choi, DY; Jhoo, WK; Kim, C; Kim, HC; Koo, CH; Lee, DW | 1 |
| Chun, IK; Gwak, HS | 1 |
| Pal, PB; Ramana, KV; Shukla, K; Sonowal, H | 1 |
Other Studies
7 other study(ies) available for aspalatone and aspirin
| Article | Year |
|---|---|
Synthesis and antiplatelet effects of the new antithrombotic agent aspalatone with low ulcerogenicity.
Topics: Adenosine Diphosphate; Animals; Antioxidants; Aspirin; Bleeding Time; Collagen; Fibrinolytic Agents; In Vitro Techniques; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 1994 |
Metabolic fate of the new antithrombotic agent aspalatone in rats. In vivo and in vitro study.
Topics: Animals; Aspirin; Biotransformation; Chromatography, High Pressure Liquid; Dealkylation; Esterases; Fibrinolytic Agents; Humans; In Vitro Techniques; Male; Platelet Aggregation Inhibitors; Prodrugs; Rats; Rats, Sprague-Dawley; Salicylates; Spectrophotometry, Ultraviolet | 1995 |
A new antithrombotic agent, aspalatone, attenuated cardiotoxicity induced by doxorubicin in the mouse; possible involvement of antioxidant mechanism.
Topics: Animals; Antibiotics, Antineoplastic; Aspirin; Body Weight; Doxorubicin; Fibrinolytic Agents; Glutathione Peroxidase; Heart; Male; Mice; Mice, Inbred ICR; Myocardium; Oxidative Stress; Pyrones; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Vitamin E | 1997 |
Salicylate levels in rat stomach tissues after administration of aspalatone and acetylsalicylic acid in relation to their ulcerogenicity.
Topics: Animals; Aspirin; Gastric Mucosa; Male; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Salicylates; Stomach Ulcer | 1997 |
Aspalatone, a new antiplatelet agent, attenuates the neurotoxicity induced by kainic acid in the rat.
Topics: Animals; Aspirin; Brain; Kainic Acid; Lipid Peroxidation; Male; Neuroprotective Agents; Oxidative Stress; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley | 1997 |
Effect of vehicles and enhancers on the in vitro skin penetration of aspalatone and its enzymatic degradation across rat skins.
Topics: Animals; Aspirin; Fibrinolytic Agents; Linoleic Acid; Male; Mice; Mice, Hairless; Pharmaceutical Vehicles; Rats; Rats, Sprague-Dawley; Skin; Skin Absorption; Species Specificity | 2001 |
Aspalatone Prevents VEGF-Induced Lipid Peroxidation, Migration, Tube Formation, and Dysfunction of Human Aortic Endothelial Cells.
Topics: Antioxidants; Aorta; Apoptosis; Aspirin; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Humans; Lipid Peroxidation; Monocytes; Signal Transduction; Vascular Endothelial Growth Factor A | 2017 |