Page last updated: 2024-09-05

aspalatone and aspirin

aspalatone has been researched along with aspirin in 7 studies

*Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) [MeSH]

*Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) [MeSH]

Compound Research Comparison

Studies
(aspalatone)
Trials
(aspalatone)
Recent Studies (post-2010)
(aspalatone)
Studies
(aspirin)
Trials
(aspirin)
Recent Studies (post-2010) (aspirin)
70148,9476,81713,778

Protein Interaction Comparison

ProteinTaxonomyaspalatone (IC50)aspirin (IC50)
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.35
Integrin beta-3Homo sapiens (human)5
Prostaglandin G/H synthase 1Ovis aries (sheep)0.8252
Seed linoleate 13S-lipoxygenase-1Glycine max (soybean)1.375
Integrin alpha-IIbHomo sapiens (human)5
Prostaglandin G/H synthase 1Homo sapiens (human)2.271
Substance-P receptorCavia porcellus (domestic guinea pig)2.4
Prostaglandin G/H synthase 2Homo sapiens (human)2.15
Urotensin-2 receptorRattus norvegicus (Norway rat)0.3
4-aminobutyrate aminotransferase, mitochondrialRattus norvegicus (Norway rat)2.4
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.35
Prostaglandin G/H synthase 2Ovis aries (sheep)2.4081

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (71.43)18.2507
2000's1 (14.29)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Han, BH; Kang, YH; Kim, YC; Park, YH; Suh, DY; Yang, HO1
Han, BH; Kim, YC; Suh, DY; Yang, HO1
Choi, DY; Choi, JH; Jhoo, WK; Kim, C; Kim, HC; Nam, SW; Park, ES1
Han, BH; Kang, YH; Suh, DY1
Choi, DY; Jhoo, WK; Kim, C; Kim, HC; Koo, CH; Lee, DW1
Chun, IK; Gwak, HS1
Pal, PB; Ramana, KV; Shukla, K; Sonowal, H1

Other Studies

7 other study(ies) available for aspalatone and aspirin

ArticleYear
Synthesis and antiplatelet effects of the new antithrombotic agent aspalatone with low ulcerogenicity.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:10

    Topics: Adenosine Diphosphate; Animals; Antioxidants; Aspirin; Bleeding Time; Collagen; Fibrinolytic Agents; In Vitro Techniques; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Stomach Ulcer

1994
Metabolic fate of the new antithrombotic agent aspalatone in rats. In vivo and in vitro study.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:10

    Topics: Animals; Aspirin; Biotransformation; Chromatography, High Pressure Liquid; Dealkylation; Esterases; Fibrinolytic Agents; Humans; In Vitro Techniques; Male; Platelet Aggregation Inhibitors; Prodrugs; Rats; Rats, Sprague-Dawley; Salicylates; Spectrophotometry, Ultraviolet

1995
A new antithrombotic agent, aspalatone, attenuated cardiotoxicity induced by doxorubicin in the mouse; possible involvement of antioxidant mechanism.
    Life sciences, 1997, Volume: 60, Issue:4-5

    Topics: Animals; Antibiotics, Antineoplastic; Aspirin; Body Weight; Doxorubicin; Fibrinolytic Agents; Glutathione Peroxidase; Heart; Male; Mice; Mice, Inbred ICR; Myocardium; Oxidative Stress; Pyrones; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Vitamin E

1997
Salicylate levels in rat stomach tissues after administration of aspalatone and acetylsalicylic acid in relation to their ulcerogenicity.
    Arzneimittel-Forschung, 1997, Volume: 47, Issue:7

    Topics: Animals; Aspirin; Gastric Mucosa; Male; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Salicylates; Stomach Ulcer

1997
Aspalatone, a new antiplatelet agent, attenuates the neurotoxicity induced by kainic acid in the rat.
    Life sciences, 1997, Volume: 61, Issue:24

    Topics: Animals; Aspirin; Brain; Kainic Acid; Lipid Peroxidation; Male; Neuroprotective Agents; Oxidative Stress; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley

1997
Effect of vehicles and enhancers on the in vitro skin penetration of aspalatone and its enzymatic degradation across rat skins.
    Archives of pharmacal research, 2001, Volume: 24, Issue:6

    Topics: Animals; Aspirin; Fibrinolytic Agents; Linoleic Acid; Male; Mice; Mice, Hairless; Pharmaceutical Vehicles; Rats; Rats, Sprague-Dawley; Skin; Skin Absorption; Species Specificity

2001
Aspalatone Prevents VEGF-Induced Lipid Peroxidation, Migration, Tube Formation, and Dysfunction of Human Aortic Endothelial Cells.
    Oxidative medicine and cellular longevity, 2017, Volume: 2017

    Topics: Antioxidants; Aorta; Apoptosis; Aspirin; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Humans; Lipid Peroxidation; Monocytes; Signal Transduction; Vascular Endothelial Growth Factor A

2017