Page last updated: 2024-12-11

sinulariolide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

sinulariolide: isolated from the marine mollusk Planaxis sulcatus; RN not in Chemline 12/86 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5358848
MeSH IDM0143591

Synonyms (8)

Synonym
episinulariolide
nsc306684
nsc-306684
sinulariolide
56326-25-1
4,5]octadec-8-en-15-one, 12-hydroxy-5,9,13-trimethyl-16-methylene-, [1r-(1r*,3s*,5s*,8e,12s*,13r*)]-
nsc-285705
(8e)-12-hydroxy-5,9,13-trimethyl-16-methylidene-4,14-dioxatricyclo[11.3.2.03,5]octadec-8-en-15-one

Research Excerpts

Overview

Sinulariolide is an active compound isolated from the cultured soft coral Sinularia flexibilis.

ExcerptReferenceRelevance
"Sinulariolide (SC-1) is a natural product extracted from the cultured-type soft coral "( Suppression of TGFβ-Induced Interleukin-6 Secretion by Sinulariolide from Soft Corals through Attenuation of the p38-NF-kB Pathway in Carcinoma Cells.
Chen, CL; Chen, JJ; Chung, CL; Ciou, YS; Lin, MW; Lin, WL; Liu, PF; Tai, SB; Yang, JL, 2023
)
2.6
"Sinulariolide is an active compound isolated from the cultured soft coral Sinularia flexibilis. "( Proteomic investigation of the sinulariolide-treated melanoma cells A375: effects on the cell apoptosis through mitochondrial-related pathway and activation of caspase cascade.
Chen, YK; Chiu, CC; Hwang, WI; Li, HH; Lin, JJ; Lo, YH; Su, JH; Wu, YJ; Yang, ZY, 2013
)
2.12
"Sinulariolide is an active compound isolated from the cultured soft coral Sinularia flexibilis. "( Sinulariolide Suppresses Human Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 through MAPKs and PI3K/Akt Signaling Pathways.
Li, HH; Neoh, CA; Su, JH; Tsao, CY; Wu, YJ, 2015
)
3.3

Treatment

Sinulariolide treatment led to loss of the mitochondrial membrane potential, release of mitochondrial cytochrome c to the cytosol, and activation of both caspase-9 and caspases-3. Food treated with sinulariolides was generally accepted at a 1% concentration.

ExcerptReferenceRelevance
"Sinulariolide treatment led to loss of the mitochondrial membrane potential, release of mitochondrial cytochrome c to the cytosol, and activation of both caspase-9 and caspase-3."( Sinulariolide induced hepatocellular carcinoma apoptosis through activation of mitochondrial-related apoptotic and PERK/eIF2α/ATF4/CHOP pathway.
Chao, HH; Chen, YJ; Huang, HH; Hung, CT; Liao, MH; Lin, JJ; Su, JH; Tsai, FJ; Tsao, CY; Weng, SH; Wu, YJ; Yang, ZY, 2013
)
2.55
"Food treated with sinulariolide (a compound previously determined to be non-bioactive) was generally accepted at a 1% concentration."( Discrimination between several diterpenoid compounds in feeding by Gambusia affinis.
Aceret, TL; Coll, JC; Sammarco, PW; Uchio, Y, 2001
)
0.63
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (11.76)18.2507
2000's1 (5.88)29.6817
2010's12 (70.59)24.3611
2020's2 (11.76)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.89

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.89 (24.57)
Research Supply Index2.94 (2.92)
Research Growth Index5.83 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.89)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]