sinulariolide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

sinulariolide: isolated from the marine mollusk Planaxis sulcatus; RN not in Chemline 12/86 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	5358848
MeSH ID	M0143591

Synonyms (8)

Synonym
episinulariolide
nsc306684
nsc-306684
sinulariolide
56326-25-1
4,5]octadec-8-en-15-one, 12-hydroxy-5,9,13-trimethyl-16-methylene-, [1r-(1r,3s,5s,8e,12s,13r*)]-
nsc-285705
(8e)-12-hydroxy-5,9,13-trimethyl-16-methylidene-4,14-dioxatricyclo[11.3.2.03,5]octadec-8-en-15-one

Research Excerpts

Overview

Sinulariolide is an active compound isolated from the cultured soft coral Sinularia flexibilis.

Excerpt	Reference	Relevance
"Sinulariolide (SC-1) is a natural product extracted from the cultured-type soft coral "	( Suppression of TGFβ-Induced Interleukin-6 Secretion by Sinulariolide from Soft Corals through Attenuation of the p38-NF-kB Pathway in Carcinoma Cells. Chen, CL; Chen, JJ; Chung, CL; Ciou, YS; Lin, MW; Lin, WL; Liu, PF; Tai, SB; Yang, JL, 2023)	2.6
"Sinulariolide is an active compound isolated from the cultured soft coral Sinularia flexibilis. "	( Proteomic investigation of the sinulariolide-treated melanoma cells A375: effects on the cell apoptosis through mitochondrial-related pathway and activation of caspase cascade. Chen, YK; Chiu, CC; Hwang, WI; Li, HH; Lin, JJ; Lo, YH; Su, JH; Wu, YJ; Yang, ZY, 2013)	2.12
"Sinulariolide is an active compound isolated from the cultured soft coral Sinularia flexibilis. "	( Sinulariolide Suppresses Human Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 through MAPKs and PI3K/Akt Signaling Pathways. Li, HH; Neoh, CA; Su, JH; Tsao, CY; Wu, YJ, 2015)	3.3

Treatment

Sinulariolide treatment led to loss of the mitochondrial membrane potential, release of mitochondrial cytochrome c to the cytosol, and activation of both caspase-9 and caspases-3. Food treated with sinulariolides was generally accepted at a 1% concentration.

Excerpt	Reference	Relevance
"Sinulariolide treatment led to loss of the mitochondrial membrane potential, release of mitochondrial cytochrome c to the cytosol, and activation of both caspase-9 and caspase-3."	( Sinulariolide induced hepatocellular carcinoma apoptosis through activation of mitochondrial-related apoptotic and PERK/eIF2α/ATF4/CHOP pathway. Chao, HH; Chen, YJ; Huang, HH; Hung, CT; Liao, MH; Lin, JJ; Su, JH; Tsai, FJ; Tsao, CY; Weng, SH; Wu, YJ; Yang, ZY, 2013)	2.55
"Food treated with sinulariolide (a compound previously determined to be non-bioactive) was generally accepted at a 1% concentration."	( Discrimination between several diterpenoid compounds in feeding by Gambusia affinis. Aceret, TL; Coll, JC; Sammarco, PW; Uchio, Y, 2001)	0.63

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (11.76)	18.2507
2000's	1 (5.88)	29.6817
2010's	12 (70.59)	24.3611
2020's	2 (11.76)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.89

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.89 (24.57)
Research Supply Index	2.94 (2.92)
Research Growth Index	5.83 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.89)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
pyrazolanthrone pyrazolanthrone: JNK (c-Jun N-terminal kinase) inhibitor; structure in first source. anthra[1,9-cd]pyrazol-6(2H)-one : A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.	2.13	1	anthrapyrazole; aromatic ketone; cyclic ketone	antineoplastic agent; c-Jun N-terminal kinase inhibitor; geroprotector
thiourea Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.	2.13	1	one-carbon compound; thioureas; ureas	antioxidant; chromophore
salubrinal salubrinal: prevents dephosphorylation of eIF2alpha; structure in first source. salubrinal : A member of the class of quinolines that is a mixed aminal resulting from the formal condensation oftrichloroacetaldehyde with the amide nitrogen of trans-cinnamamide and the primary amino group of 1-quinolin-8-ylthiourea. It is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha).	2.13	1	aminal; organochlorine compound; quinolines; secondary carboxamide; thioureas
acid phosphatase Acid Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.	2.08	1
cytochrome c-t Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.	2.07	1
interleukin-8 Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.	7.08	1
epidermal growth factor Epidermal Growth Factor: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.	2.08	1
transforming growth factor beta Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.	2.6	1
flexibilide flexibilide: cembranoid lactone; structure in first source & in UD 32;123h	7.69	3

Condition	Relationship Strength	Studies
Cancer of Mouth [description not available]	2.6	1
Mouth Neoplasms Tumors or cancer of the MOUTH.	2.6	1
Carcinoma, Anaplastic [description not available]	2.6	1
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	7.6	1
Metastase [description not available]	2.54	2
Cancer of Stomach [description not available]	2.21	1
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.54	2
Stomach Neoplasms Tumors or cancer of the STOMACH.	2.21	1
Bladder Cancer [description not available]	7.51	2
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	2.51	2
Adjuvant Arthritis [description not available]	2.08	1
Bone Loss, Osteoclastic [description not available]	2.08	1
Innate Inflammatory Response [description not available]	2.08	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.08	1
Malignant Melanoma [description not available]	2.08	1
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	7.08	1
Hepatocellular Carcinoma [description not available]	3.02	4
Cancer of Liver [description not available]	3.02	4
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	3.02	4
Liver Neoplasms Tumors or cancer of the LIVER.	3.02	4
Invasiveness, Neoplasm [description not available]	2.1	1
Lung Adenocarcinoma [description not available]	7.13	1
Adenocarcinoma, Basal Cell [description not available]	2.13	1
Cancer of Lung [description not available]	2.13	1
Adenocarcinoma of Lung A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.	2.13	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	7.13	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.13	1
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	1.99	1

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