| Assay ID | Title | Year | Journal | Article |
|---|
| AID1233536 | Selectivity ratio of Ki(app) for human recombinant BACE2 to Ki for human recombinant BACE1 | 2015 | Journal of medicinal chemistry, Jul-23, Volume: 58, Issue:14
| Peptidomimetic β-Secretase Inhibitors Comprising a Sequence of Amyloid-β Peptide for Alzheimer's Disease. |
| AID1233535 | Apparent inhibition of human recombinant BACE2 using Mca-SEVNLDAEFK-DNP substrate assessed as substrate hydrolysis after 1 hr by HPLC-FLU analysis | 2015 | Journal of medicinal chemistry, Jul-23, Volume: 58, Issue:14
| Peptidomimetic β-Secretase Inhibitors Comprising a Sequence of Amyloid-β Peptide for Alzheimer's Disease. |
| AID1233548 | Inhibition of active BACE1 (unknown origin) | 2015 | Journal of medicinal chemistry, Jul-23, Volume: 58, Issue:14
| Peptidomimetic β-Secretase Inhibitors Comprising a Sequence of Amyloid-β Peptide for Alzheimer's Disease. |
| AID1233540 | Cytotoxicity against human Caco2 cells assessed as cell viability at 25 to 50 uM after 24 hrs by MTS assay | 2015 | Journal of medicinal chemistry, Jul-23, Volume: 58, Issue:14
| Peptidomimetic β-Secretase Inhibitors Comprising a Sequence of Amyloid-β Peptide for Alzheimer's Disease. |
| AID1233539 | Cytotoxicity against human Caco2 cells assessed as cell viability at 25 to 50 uM after 4 to 24 hrs by MTS assay | 2015 | Journal of medicinal chemistry, Jul-23, Volume: 58, Issue:14
| Peptidomimetic β-Secretase Inhibitors Comprising a Sequence of Amyloid-β Peptide for Alzheimer's Disease. |
| AID432677 | Inhibition of full-domain of BACE1 expressed in HEK393 cells | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| Prolonged stability by cyclization: Macrocyclic phosphino dipeptide isostere inhibitors of beta-secretase (BACE1). |
| AID1233534 | Inhibition of human recombinant BACE1 using Mca-SEVNLDAEFK-DNP substrate assessed as substrate hydrolysis after 2 hrs by HPLC-FLU analysis | 2015 | Journal of medicinal chemistry, Jul-23, Volume: 58, Issue:14
| Peptidomimetic β-Secretase Inhibitors Comprising a Sequence of Amyloid-β Peptide for Alzheimer's Disease. |
| AID296063 | Inhibition of human BACE1 expressed in HEK293 cells | 2007 | Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12
| Synthesis and biological evaluation of phosphino dipeptide isostere inhibitor of human beta-secretase (BACE1). |
| AID636691 | Inhibition of human recombinant BACE1 ectodomain (1 to 460 amino acids) assessed as inhibition of proteolytic cleavage of Rhodamine-EVNLDAEFK-Quencher substrate after 35 mins by FRET assay | 2011 | Journal of medicinal chemistry, Apr-28, Volume: 54, Issue:8
| On a possible neutral charge state for the catalytic dyad in β-secretase when bound to hydroxyethylene transition state analogue inhibitors. |
| AID1233537 | Half life in human serum by HPLC-FLU analysis | 2015 | Journal of medicinal chemistry, Jul-23, Volume: 58, Issue:14
| Peptidomimetic β-Secretase Inhibitors Comprising a Sequence of Amyloid-β Peptide for Alzheimer's Disease. |
| AID1233538 | Half life in mouse brain by HPLC-FLU analysis | 2015 | Journal of medicinal chemistry, Jul-23, Volume: 58, Issue:14
| Peptidomimetic β-Secretase Inhibitors Comprising a Sequence of Amyloid-β Peptide for Alzheimer's Disease. |
| AID1811 | Experimentally measured binding affinity data derived from PDB | 2002 | Biochemistry, Sep-10, Volume: 41, Issue:36
| Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 2002 | Biochemistry, Sep-10, Volume: 41, Issue:36
| Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |