Page last updated: 2024-11-08
norbelladine
Description
norbelladine: common metabolic intermediate [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
norbelladine : A phenethylamine alkaloid that is tyramine in which one of the amino hydrogens has been replaced by a 3,4-dihydroxybenzyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
Synonyms (11)
| Synonym |
|---|
| NCIOPEN2_004541 |
| norbelladine |
| 4-[[2-(4-hydroxyphenyl)ethylamino]methyl]benzene-1,2-diol |
| AKOS010487570 |
| CHEBI:80666 , |
| 4-({[2-(4-hydroxyphenyl)ethyl]amino}methyl)benzene-1,2-diol |
| SCHEMBL5066630 |
| 4-(([2-(4-hydroxyphenyl)ethyl]amino)methyl)-1,2-benzenediol # |
| YJYUDTAJVLORNV-UHFFFAOYSA-N |
| CHEMBL3359303 |
| Q27149708 |
Research Excerpts
Overview
Norbelladine is an amine compound, a precursor for Amaryllidaceae alkaloids. It is found in plants traditionally used for treating a variety of human diseases.
Roles (1)
| Role | Description |
|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (4)
| Class | Description |
|---|
| phenethylamine alkaloid | |
| polyphenol | Members of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group. |
| secondary amino compound | A compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups. |
| catechols | Any compound containing an o-diphenol component. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Bioassays (5)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID1172900 | Inhibition of COX2 (unknown origin) using arachidonic acid as substrate at 0.25 uM after 10 mins by luminometry | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
| Synthesis and characterization of norbelladine, a precursor of Amaryllidaceae alkaloid, as an anti-inflammatory/anti-COX compound. |
| AID1172902 | Inhibition of LPS-induced NF-kappaB p65 activation in human THP1 cells preincubated at 10 uM for 15 mins before LPS treatment measured after 16 hrs | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
| Synthesis and characterization of norbelladine, a precursor of Amaryllidaceae alkaloid, as an anti-inflammatory/anti-COX compound. |
| AID1172898 | Antioxidant activity assessed as superoxide anion radical scavenging activity at 5 to 20 uM by xanthine/xanthine oxidase assay | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
| Synthesis and characterization of norbelladine, a precursor of Amaryllidaceae alkaloid, as an anti-inflammatory/anti-COX compound. |
| AID1172899 | Inhibition of COX1 (unknown origin) using arachidonic acid as substrate at 0.25 uM after 10 mins by luminometry | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
| Synthesis and characterization of norbelladine, a precursor of Amaryllidaceae alkaloid, as an anti-inflammatory/anti-COX compound. |
| AID1172897 | Antioxidant activity assessed as DPPH scavenging activity at 5 to 20 uM after 15 mins by UV-visible spectrophotometry | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
| Synthesis and characterization of norbelladine, a precursor of Amaryllidaceae alkaloid, as an anti-inflammatory/anti-COX compound. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 3 (60.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 26.46
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 26.46 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.92 (4.65) | | Search Engine Demand Index | 26.67 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |