Compounds > nodosin
Page last updated: 2024-11-12

nodosin

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Description

nodosin: has anti-inflammatory activity; isolated from Isodon serra; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
IsodongenusA plant genus of the family LAMIACEAE used in TRADITIONAL CHINESE MEDICINE.[MeSH]LamiaceaeThe mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]

Cross-References

ID SourceID
PubMed CID10248089
CHEMBL ID510160
CHEBI ID70379
MeSH IDM0545807

Synonyms (12)

Synonym
nodosin
10391-09-0
CHEMBL510160
chebi:70379 ,
11-deacetylsinuolatin e; nsc 285659; nodosin (terpene)
AKOS032962396
Q27138718
(1s,4s,8r,9r,12s,13s,14r,16s)-9,14-dihydroxy-7,7-dimethyl-17-methylidene-3,10-dioxapentacyclo[14.2.1.01,13.04,12.08,12]nonadecane-2,18-dione
MS-25755
HY-N3181
CS-0023521
F92771
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
delta-lactoneA lactone having a six-membered lactone ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (105)

Assay IDTitleYearJournalArticle
AID1871084Antimigratory activity against human T24 cells assessed as down regulation of CFL2 expression at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1058650Cytotoxicity against human SMMC7721 cells after 48 hrs by MTS assay2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Enmein-type 6,7-seco-ent-kauranoids from Isodon sculponeatus.
AID1871079Up regulation of FTL expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871003Cytotoxicity against human UMUC3 cells assessed as reduction in cell growth at 4 uM by CCK8 assay2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871000Cytotoxicity against human UMUC3 cells assessed as reduction in cell growth by CCK8 assay2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871011Effect on RNF169 expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871043Up regulation of HMOX1 expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871085Antimigratory activity against human T24 cells assessed as down regulation of PALLD expression at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871092Antitumor activity against human T24 cells xenografted in BALB/c mouse assessed as reduction in mitotic count at 2 mg/kg, ip administered at 2 days interval by H and E staining based assay2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1870999Cytotoxicity against human T24 cells assessed as reduction in cell growth by CCK8 assay2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871067Induction of apoptosis in human T24 cells assessed as up regulation of MAP1LC3B expression at 6 to 12 uM measured after 24 to 30 hrs by Western blot analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871044Induction of apoptosis in human T24 cells assessed as effect on G0S2 expression at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871037Induction of apoptosis in human T24 cells assessed as necrotic cells at 6 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.57%)2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871008Inhibition of colony formation in human T24 cells at 1 to 12 uM measured after 12 days by crystal violet staining based microscopy2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871060Induction of autophagy in human T24 cells assessed as effect on CISD2 gene expression at 6 uM measured after 12 to 18 hrs by transcriptome analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871089Antitumor activity against human T24 cells xenografted in BALB/c mouse assessed as reduction in tumor growth at 2 mg/kg, ip administered at 2 days interval2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871066Induction of apoptosis in human T24 cells assessed as up regulation of SQSTM1 expression at 6 to 12 uM measured after 24 to 30 hrs by Western blot analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871035Induction of apoptosis in human T24 cells assessed as early apoptotic cells at 6 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 1.2%)2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871064Induction of autophagy in human T24 cells assessed as up regulation of MAP1LC3B gene expression at 6 uM measured after 12 to 18 hrs by transcriptome analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871053Induction of autophagy in human T24 cells assessed as up regulation of SQSTM1 expression at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1058646Inhibition of LPS-stimulated NO production in mouse RAW264.7 cells after 18 hrs by Griess assay2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Enmein-type 6,7-seco-ent-kauranoids from Isodon sculponeatus.
AID1871015Effect on E2F6 expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871093Antitumor activity against human T24 cells xenografted in BALB/c mouse assessed as reduction in Ki67 expression at 2 mg/kg, ip administered at 2 days interval by immunohistochemical analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871049Induction of apoptosis in human T24 cells assessed as effect on DHCR24 expression at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871081Up regulation of AIFM2 expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871070Cytotoxicity against human T24 cells assessed as reduction in cell growth measured after 24 hrs in presence of autophagy inhibitor chloroquine by CCK8 assay2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871069Induction of apoptosis in human T24 cells assessed as up regulation of LC3 expression at 6 to 12 uM measured after 24 hrs by immunofluorescence analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871056Induction of autophagy in human T24 cells assessed as effect on SQSTM1 gene expression at 6 uM measured after 12 to 18 hrs by transcriptome analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871051Induction of apoptosis in human T24 cells assessed as effect on ARL6IP1 expression at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871050Induction of apoptosis in human T24 cells assessed as effect on TRIAP1 expression at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1058648Cytotoxicity against human MCF7 cells after 48 hrs by MTS assay2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Enmein-type 6,7-seco-ent-kauranoids from Isodon sculponeatus.
AID1871029Cytotoxicity against human T24 cells assessed as reduction in cell growth measured after 24 hrs in presence of antioxidant NAC by CCK8 assay2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871078Up regulation of AIFM2 gene expression in human T24 cells at 6 uM measured after 12 to 18 hrs by transcriptome analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871032Induction of apoptosis in human T24 cells assessed as late apoptotic cells at 4 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.74%)2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871023Effect on POLD3 expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871021Effect on NBN expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871094Antitumor activity against human T24 cells xenografted in BALB/c mouse assessed as increase in HMOX1expression at 2 mg/kg, ip administered at 2 days interval by immunohistochemical analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871090Antitumor activity against human T24 cells xenografted in BALB/c mouse assessed as reduction in tumor weight at 2 mg/kg, ip administered at 2 days interval2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871058Induction of autophagy in human T24 cells assessed as effect on LGALS8 gene expression at 6 uM measured after 12 to 18 hrs by transcriptome analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871014Effect on CLSPN expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871086Antimigratory activity against human T24 cells assessed as down regulation of ITGA3 expression at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871068Induction of apoptosis in human T24 cells assessed as up regulation of SQSTM1 expression at 6 to 12 uM measured after 24 hrs by immunofluorescence analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID471322Cytotoxicity against human HepG2 cells after 48 hrs2009Journal of natural products, Oct, Volume: 72, Issue:10
ent-Kaurane and cembrane diterpenoids from Isodon sculponeatus and their cytotoxicity.
AID1871082Antimigratory activity against human T24 cells assessed as down regulation of NEXN expression at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID471321Cytotoxicity against human A549 cells after 48 hrs2009Journal of natural products, Oct, Volume: 72, Issue:10
ent-Kaurane and cembrane diterpenoids from Isodon sculponeatus and their cytotoxicity.
AID1871001Cytotoxicity against human SW780 cells assessed as reduction in cell growth by CCK8 assay2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871010Cell cycle arrest in human T24 cells assessed as increase in cell accumulation at S-phase at 2 to 8 uM measured after 24 hrs by propidium iodide staining based flow cytometry2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871030Induction of apoptosis in human T24 cells assessed as viable cells at 4 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 97.49%)2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871025Effect on SUMO3 expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871046Induction of apoptosis in human T24 cells assessed as effect on AIFM2 expression at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871055Induction of autophagy in human T24 cells assessed as effect on PRKAA2 gene expression at 6 uM measured after 12 to 18 hrs by transcriptome analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871048Induction of apoptosis in human T24 cells assessed as effect on RMDN3 expression at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871074Induction of morphological changes in human T24 cells assessed as appearance of apoptotic bodies at 4 to 8 uM measured after 48 hrs by transmission electron microscopy2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871027Induction of ROS generation in human T24 cells at 4 to 10 uM measured after 6 hrs by H2DCFDA probe based flow cytometry2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871033Induction of apoptosis in human T24 cells assessed as necrotic cells at 4 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.57%)2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871091Toxicity in human T24 cells xenografted BALB/c mouse assessed as effect on body weight at 2 mg/kg, ip administered at 2 days interval2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871040Induction of apoptosis in human T24 cells assessed as late apoptotic cells at 8 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.74%)2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871063Induction of apoptosis in human T24 cells assessed as up regulation of SQSTM1 gene expression at 6 uM measured after 12 to 18 hrs by transcriptome analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1058649Cytotoxicity against human A549 cells after 48 hrs by MTS assay2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Enmein-type 6,7-seco-ent-kauranoids from Isodon sculponeatus.
AID1058647Cytotoxicity against human SW480 cells after 48 hrs by MTS assay2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Enmein-type 6,7-seco-ent-kauranoids from Isodon sculponeatus.
AID1871041Induction of apoptosis in human T24 cells assessed as necrotic cells at 8 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.57%)2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871016Effect on MDC1 expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871007Induction of morphological changes in human T24 cells assessed as cell shrinkage at 4 to 12 uM measured after 48 hrs by microscopy2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871006Induction of morphological changes in human T24 cells assessed as cytoplasmic condensation at 4 to 12 uM measured after 48 hrs by microscopy2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871076Up regulation of FTL gene expression in human T24 cells at 6 uM measured after 12 to 18 hrs by transcriptome analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871026Inhibition of DNA replication in human T24 cells at 4 to 10 uM measured after 24 hrs by EdU staining based fluorescence assay2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871087Antimigratory activity against human T24 cells at 4 to 12 uM measured after 24 hrs by scratch test2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871083Antimigratory activity against human T24 cells assessed as down regulation of LIMA1 expression at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871036Induction of apoptosis in human T24 cells assessed as late apoptotic cells at 6 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.74%)2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871088Antimigratory activity against human T24 cells assessed as reduction in F-actin expression at 8 to 20 uM measured after 24 hrs by actin-tracker red-594/DAPI staining based fluorescence assay2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871018Effect on HLTF expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1058651Cytotoxicity against human HL60 cells after 48 hrs by MTS assay2013Journal of natural products, Nov-22, Volume: 76, Issue:11
Enmein-type 6,7-seco-ent-kauranoids from Isodon sculponeatus.
AID1871002Cytotoxicity against human T24 cells assessed as reduction in cell growth at 4 uM by CCK8 assay2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871004Induction of morphological changes in human T24 cells assessed as reduction in cell extension at 4 to 12 uM measured after 48 hrs by microscopy2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871080Up regulation of SLC7A11 expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871022Effect on MSH2 expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871061Induction of autophagy in human T24 cells assessed as effect on WDR41 gene expression at 6 uM measured after 12 to 18 hrs by transcriptome analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871075Cytotoxicity against human T24 cells assessed as reduction in cell growth measured after 24 hrs in presence of ferroptosis inhibitor ferrostatin-1 by CCK8 assay2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871013Effect on RPA2 expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871073Induction of cell membrane disruption in human T24 cells at 4 to 8 uM measured after 48 hrs by transmission electron microscopy2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871059Induction of autophagy in human T24 cells assessed as effect on OPTN gene expression at 12 to 18 uM measured after 24 to 30 hrs by analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871005Induction of morphological changes in human T24 cells assessed as reduction in cell adherence at 4 to 12 uM measured after 48 hrs by microscopy2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871042Induction of mitochondrial membrane potential loss in human T24 cells at 8 to 16 uM measured after 24 hrs by JC1 dye based fluorescence assay2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871024Effect on RHOB expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871038Induction of apoptosis in human T24 cells assessed as viable cells at 8 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 97.49%)2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871057Induction of autophagy in human T24 cells assessed as effect on RAB24 gene expression at 6 uM measured after 12 to 18 hrs by transcriptome analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871054Induction of autophagy in human T24 cells assessed as effect on FLCN gene expression at 6 uM measured after 12 to 18 hrs by transcriptome analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871047Induction of apoptosis in human T24 cells assessed as effect on SQSTM1 expression at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871077Up regulation of SLC7A11 gene expression in human T24 cells at 6 uM measured after 12 to 18 hrs by transcriptome analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871045Induction of apoptosis in human T24 cells assessed as effect on ZFP36L1 expression at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871019Effect on NEK6 expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID471320Cytotoxicity against human K562 cells after 48 hrs2009Journal of natural products, Oct, Volume: 72, Issue:10
ent-Kaurane and cembrane diterpenoids from Isodon sculponeatus and their cytotoxicity.
AID1871052Induction of apoptosis in human T24 cells assessed as effect on FAM168A expression at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871065Induction of apoptosis in human T24 cells assessed as up regulation of HMOX1 expression at 6 to 12 uM measured after 24 to 30 hrs by Western blot analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871009Antiproliferative activity against human T24 cells assessed as reduction in Ki67 expression at 4 to 12 uM measured after 24 hrs by DAPI staining based immunofluorescence analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871012Effect on CDKN3 expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871020Effect on DDB1 expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871072Induction of cell membrane disruption in human T24 cells at 4 to 20 uM measured after 24 hrs by Dio/Hoechst 33342 staining based fluorescence assay2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871062Induction of apoptosis in human T24 cells assessed as up regulation of HMOX1 gene expression at 6 uM measured after 12 to 18 hrs by transcriptome analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871034Induction of apoptosis in human T24 cells assessed as viable cells at 6 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 97.49%)2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871031Induction of apoptosis in human T24 cells assessed as early apoptotic cells at 4 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 1.2%)2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1870998Cytotoxicity against human T24 cells assessed as reduction in cell growth measured after 24 hrs by live/dead staining based fluorescence assay2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871071Induction of mitochondrial membrane disruption in human T24 cells at 4 to 8 uM measured after 48 hrs by transmission electron microscopy2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871017Effect on PDCD2L expression in human T24 cells at 6 uM measured after 24 to 30 hrs by proteomic analysis2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
AID1871039Induction of apoptosis in human T24 cells assessed as early apoptotic cells at 8 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 1.2%)2022Journal of natural products, 08-26, Volume: 85, Issue:8
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's5 (71.43)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 69.60

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index69.60 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index111.49 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (69.60)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0810taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
enmein
enmein: structure		2.4720delta-lactonemetabolite
benzyloxycarbonylleucyl-leucyl-leucine aldehyde
benzyloxycarbonylleucyl-leucyl-leucine aldehyde: proteasome inhibitor. N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal : A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.		2.0810amino aldehyde;
carbamate ester;
tripeptide		proteasome inhibitor
ovatodiolide
ovatodiolide: from Anisomeles indica; structure in first source		2.0510
oridonin
[no description available]		2.0710
ConditionIndicatedRelationship StrengthStudiesTrials
Bladder Cancer
[description not available]		08.3310
Urinary Bladder Neoplasms
Tumors or cancer of the URINARY BLADDER.		03.3310
Anasarca
[description not available]		02.0510
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.0510
Injury, Ischemia-Reperfusion
[description not available]		02.4820
Reperfusion Injury
Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.		07.4820
B16 Melanoma
[description not available]		02.0710