nodosin and enmein

nodosin has been researched along with enmein* in 1 studies

Other Studies

1 other study(ies) available for nodosin and enmein

ArticleYear
Enmein-type 6,7-seco-ent-kauranoids from Isodon sculponeatus.
    Journal of natural products, 2013, Nov-22, Volume: 76, Issue:11

    Fourteen enmein-type 6,7-seco-ent-kaurane diterpenoids, seven new ones (sculponins M-S, 1-7) and seven known compounds (8-14), were isolated from the aerial parts of Isodon sculponeatus . Compound 1 is the first example of an ent-kauranoid, possessing a 11,12-epoxy group, and compounds 6 and 7 have a rare 3,6-epoxy group. The structures were established primarily by NMR and MS methods, and the absolute configurations of 1, 3, and 6 were determined by single-crystal X-ray diffraction. Compound 14 showed significant cytotoxic activity against five human tumor lines, with IC50 values ranging from 1.0 to 3.5 μM, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC50 value of 2.2 μM.

    Topics: Antineoplastic Agents, Phytogenic; Crystallography, X-Ray; Diterpenes; Diterpenes, Kaurane; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Isodon; Lipopolysaccharides; Molecular Conformation; Molecular Structure; Nitric Oxide; Nuclear Magnetic Resonance, Biomolecular

2013