Compounds > ici 142269
Page last updated: 2024-12-10

ici 142269

Description

ICI 142269: RN given refers to (Z)-isomer; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3033897
CHEMBL ID46128
SCHEMBL ID4620164
MeSH IDM0149323

Synonyms (17)

Synonym
ici 142269
CHEMBL46128
2-[4-[(z)-1,2-diphenylbut-1-enyl]phenoxy]ethanol
77207-49-9
ici-142269
deamino-hydroxytamoxifen
ethanol, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-, (z)-
tamoxifen metabolite y
tamoxifen-ol
SCHEMBL4620164
Q32039328
(z)-2-(4-(1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol
DTXSID701219780
2-[4-[(1z)-1,2-diphenyl-1-buten-1-yl]phenoxy]ethanol
ethanol, 2-[4-[(1z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-
F74719
AKOS040751446
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pathways (1)

PathwayProteinsCompounds
Tamoxifen metabolism013

Bioassays (1)

Assay IDTitleYearJournalArticle
AID69397Displacement of [3H]estradiol from estrogen receptor in rat uterine cytosol1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Antiestrogen basicity--activity relationships: a comparison of the estrogen receptor binding and antiuterotrophic potencies of several analogues of (Z)-1,2-diphenyl-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-butene (tamoxifen, Nolvadex) having altered basici
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (66.67)18.7374
1990's2 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.41 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
afimoxifene
afimoxifene : A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.		3.0750phenols;
tertiary amino compound		antineoplastic agent;
estrogen receptor antagonist;
metabolite
tamoxifen
[no description available]		3.2260stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
desdimethyltamoxifen
N,N-didesmethyltamoxifen: structure in first source		1.9810stilbenoid
n-desmethyltamoxifen
N-desmethyltamoxifen: main metabolite of tamoxifen; RN given refers to (Z)-isomer		3.0750stilbenoid
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		01.9810
Breast Cancer
[description not available]		02.8840
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.8840
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