GPI0100: quillaja saponin semi-synthetic analog; a systemic and mucosal adjuvant, has potential use in the development of vaccines against periodontal, as well as other pathogens [MeSH]
| ID Source | ID |
|---|---|
| PubMed CID | 56841660 |
| MeSH ID | M0465770 |
| Synonym |
|---|
| gpi 0100 |
| gpi0100 |
| ic5v8479h3 , |
| gpi-0100 |
| 328056-98-0 |
| unii-ic5v8479h3 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 9 (56.25) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (6.25%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 15 (93.75%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| aluminum phosphate | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |||
| beta-escin | 2003 | 2022 | 11.9 | high | 1 | 0 | 0 | 6 | 9 | 1 | |||
| lipid a | dodecanoate ester; lipid A; tetradecanoate ester | Escherichia coli metabolite | 2003 | 2015 | 15.0 | low | 0 | 0 | 0 | 1 | 1 | 0 | |
| oligonucleotides | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |||
| qs 21 | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |||
| folic acid | folic acids; N-acyl-amino acid | human metabolite; mouse metabolite; nutrient | 2013 | 2013 | 11.0 | low | 1 | 0 | 0 | 0 | 1 | 0 | |
| quillaja saponins | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adenocarcinoma | 0 | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Adenocarcinoma Of Kidney | 0 | 2013 | 2013 | 11.0 | low | 1 | 0 | 0 | 0 | 1 | 0 | |
| Adenocarcinoma, Basal Cell | 0 | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Benign Neoplasms | 0 | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Cancer of Kidney | 0 | 2013 | 2013 | 11.0 | low | 1 | 0 | 0 | 0 | 1 | 0 | |
| Cancer of Lung | 0 | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Cancer of Prostate | 0 | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Carcinoma, Renal Cell | 0 | 2013 | 2013 | 11.0 | low | 1 | 0 | 0 | 0 | 1 | 0 | |
| Carcinoma, Small Cell Lung | 0 | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Disease Models, Animal | 0 | 2006 | 2014 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 | |
| Genital Herpes | 0 | 2006 | 2008 | 17.0 | low | 0 | 0 | 0 | 2 | 0 | 0 | |
| Herpes Genitalis | 0 | 2006 | 2008 | 17.0 | low | 0 | 0 | 0 | 2 | 0 | 0 | |
| Herpes Simplex | 0 | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Herpes Simplex Virus Infection | 0 | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| HPV Infection | 0 | 2009 | 2019 | 9.7 | low | 0 | 0 | 0 | 1 | 2 | 0 | |
| Infections, Orthomyxoviridae | 0 | 2011 | 2014 | 11.7 | low | 0 | 0 | 0 | 0 | 3 | 0 | |
| Kidney Neoplasms | 0 | 2013 | 2013 | 11.0 | low | 1 | 0 | 0 | 0 | 1 | 0 | |
| Lung Neoplasms | 0 | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Neoplasms | 0 | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Orthomyxoviridae Infections | 0 | 2011 | 2014 | 11.7 | low | 0 | 0 | 0 | 0 | 3 | 0 | |
| Papillomavirus Infections | 0 | 2009 | 2019 | 9.7 | low | 0 | 0 | 0 | 1 | 2 | 0 | |
| Prostatic Neoplasms | 0 | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Recrudescence | 0 | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Small Cell Lung Carcinoma | 0 | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Article | Year |
|---|---|
| A phase I study of folate immune therapy (EC90 vaccine administered with GPI-0100 adjuvant followed by EC17) in patients with renal cell carcinoma. Journal of immunotherapy (Hagerstown, Md. : 1997), , Volume: 36, Issue:4 | 2013 |