Page last updated: 2024-11-13

gpi0100

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

GPI0100: quillaja saponin semi-synthetic analog; a systemic and mucosal adjuvant, has potential use in the development of vaccines against periodontal, as well as other pathogens [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Quillaja	genus	A plant genus of the family ROSACEAE whose members produce SAPONINS.[MeSH]	Quillajaceae	[no description available]

Cross-References

ID Source	ID
PubMed CID	56841660
MeSH ID	M0465770

Synonyms (6)

Synonym
gpi 0100
gpi0100
ic5v8479h3 ,
gpi-0100
328056-98-0
unii-ic5v8479h3

Research Excerpts

Compound-Compound Interactions

Excerpt	Reference	Relevance
"This is the first phase I, open-label study to assess the safety, pharmacokinetics, and antitumor activity of a novel immunotherapeutic regimen known as Folate Immune (EC90 vaccine administered with GPI-0100 adjuvant followed by EC17, a folate-targeted hapten immunotherapy that targets folate receptor expressing cancer cells), which is designed to convert poorly immunogenic tumors to highly immunogenic tumors in patients with metastatic renal cell carcinoma."	( A phase I study of folate immune therapy (EC90 vaccine administered with GPI-0100 adjuvant followed by EC17) in patients with renal cell carcinoma. Amato, RJ; Ellis, R; Low, PS; Lu, Y; Shetty, A, 2013)	0.39

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (37.50)	29.6817
2010's	9 (56.25)	24.3611
2020's	1 (6.25)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.77

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.77 (24.57)
Research Supply Index	2.89 (2.92)
Research Growth Index	4.66 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.77)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (6.25%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (93.75%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
aluminum phosphate aluminum phosphate: gel used as immunologic adjuvent; RN given refers to Al salt	2.01	1	0
beta-escin [no description available]	5.6	16	1
lipid a Lipid A: Lipid A is the biologically active component of lipopolysaccharides. It shows strong endotoxic activity and exhibits immunogenic properties.. lipid A : The glycolipid moiety of bacterial lipopolysaccharide (R can be either hydrogen or a fatty acyl group).	2.45	2	0	dodecanoate ester; lipid A; tetradecanoate ester	Escherichia coli metabolite
oligonucleotides [no description available]	2.11	1	0
qs 21 [no description available]	2.02	1	0
folic acid folcysteine: used to promote fertility in chickens. vitamin B9 : Any B-vitamin that exhibits biological activity against vitamin B9 deficiency. Vitamin B9 refers to the many forms of folic acid and its derivatives, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid amongst others. They are present in abundance in green leafy vegetables, citrus fruits, and animal products. Lack of vitamin B9 leads to anemia, a condition in which the body cannot produce sufficient number of red blood cells. Symptoms of vitamin B9 deficiency include fatigue, muscle weakness, and pale skin.	3.47	1	1	folic acids; N-acyl-amino acid	human metabolite; mouse metabolite; nutrient
quillaja saponins Quillaja Saponins: Natural detergents made up of a heterogeneous mixture of molecules having a triterpenoid core structure. They vary in aglycone (sapogenin) and sugar moieties, including glucose.	7.41	1	0

Condition	Relationship Strength	Studies	Trials
HPV Infection [description not available]	2.79	3	0
Papillomavirus Infections Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.	2.79	3	0
Adenocarcinoma Of Kidney [description not available]	3.47	1	1
Cancer of Kidney [description not available]	3.47	1	1
Carcinoma, Renal Cell A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.	3.47	1	1
Kidney Neoplasms Tumors or cancers of the KIDNEY.	3.47	1	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.46	2	0
Infections, Orthomyxoviridae [description not available]	2.77	3	0
Orthomyxoviridae Infections Virus diseases caused by the ORTHOMYXOVIRIDAE.	2.77	3	0
Benign Neoplasms [description not available]	2.11	1	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.11	1	0
Genital Herpes [description not available]	2.44	2	0
Herpes Genitalis Infection of the genitals (GENITALIA) with HERPES SIMPLEX VIRUS in either the males or the females.	2.44	2	0
Carcinoma, Small Cell Lung [description not available]	2.05	1	0
Adenocarcinoma, Basal Cell [description not available]	2.05	1	0
Cancer of Lung [description not available]	2.05	1	0
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.05	1	0
Lung Neoplasms Tumors or cancer of the LUNG.	2.05	1	0
Small Cell Lung Carcinoma A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).	2.05	1	0
Recrudescence [description not available]	2.02	1	0
Cancer of Prostate [description not available]	2.02	1	0
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.02	1	0
Herpes Simplex Virus Infection [description not available]	2.03	1	0
Herpes Simplex A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)	7.03	1	0

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