glaziovine: a proaporphine alkaloid isolated from Ocotea glaziovii (Lauraceae) found to be similar in activity as an anxiolitic drug to diazepam; structure; RN given refers to (S)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Ocotea | genus | A plant genus in the LAURACEAE family. The common name of stinkwood is also used for Zieria (RUTACEAE).[MeSH] | Lauraceae | A family of mainly aromatic evergreen plants in the order Laurales. The laurel family includes 2,200 species in 45 genera and from these are derived medicinal extracts, essential oils, camphor and other products.[MeSH] |
| Ocotea glaziovii | species | [no description available] | Lauraceae | A family of mainly aromatic evergreen plants in the order Laurales. The laurel family includes 2,200 species in 45 genera and from these are derived medicinal extracts, essential oils, camphor and other products.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 65631 |
| CHEMBL ID | 1980854 |
| SCHEMBL ID | 554440 |
| MeSH ID | M0051270 |
| Synonym |
|---|
| nsc141545 , |
| nsc-141545 |
| spiro[2,7'(1'h)-cyclopent[ij]isoquinolin]-4-one, 2',3',8',8'a-tetrahydro-6'-hydroxy-5'-methoxy-1'-methyl-, (s)- |
| glaziovine |
| spiro[2,7'(1'h)-cyclopent[ij]isoquinolin]-4-one, 2',3',8',8'a-tetrahydro-6'-hydroxy-5'-methoxy-1'-methyl-, (.+-.)- |
| glaziovine, (.+-.)- |
| 17127-48-9 |
| nsc-146052 |
| (.+-.)-glaziovine |
| nsc146052 |
| NCI60_000910 |
| AC1L9CHE , |
| spiro(2,5-cyclohexadiene-1,7'(1'h)-cyclopent(ij)isoquinolin)-4-one, 2',3',8',8'a-tetrahydro-6'-hydroxy-5'-methoxy-1'-methyl-, (+-)- |
| glaziovine [inn] |
| ke7j8a65p6 , |
| unii-ke7j8a65p6 |
| glaziovinum |
| nsc 146052 |
| ai3-34588 |
| glaziovina [inn-spanish] |
| glaziovinum [inn-latin] |
| (+-)-glaziovine |
| CHEMBL1980854 |
| (+/-)-glaziovine |
| AKOS022181549 |
| SCHEMBL554440 |
| 6'-hydroxy-5'-methoxy-1'-methyl-2',3',8',8a'-tetrahydro-1'h-spiro[cyclohexa[2,5]diene-1,7'-cyclopenta[ij]isoquinolin]-4-one |
| glaziovinae |
| DTXSID90864739 |
| 2,3,4,6-tetra-o-benzoyl-alpha-d-glucopyranosylbromide |
| (+/-)-2',3',8',8a'-tetrahydro-6'-hydroxy-5'-methoxy-1'-methylspiro[2,5-cyclohexadiene-1,7'(1'h)-cyclopent[ij]isoquinolin]-4-one |
| 11-hydroxy-10-methoxy-5-methylspiro[5-azatricyclo[6.3.1.04,12]dodeca-1(12),8,10-triene-2,4'-cyclohexa-2,5-diene]-1'-one |
| Excerpt | Reference | Relevance |
|---|---|---|
| " and oral administration, percentages of bioavailability were obtained ranging from 80 to 98%." | ( Absorption, fate and excretion of glaziovine-14C in the dog. Ghirardi, P; Marchetti, G; Marzo, A; Merlo, L, 1977) | 0.54 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID301053 | Selectivity index, ratio of CC50 for human Hep G2.2.15 cells to IC50 for surface antigen HBsAg secretion in HBV transfected Hep G2.2.15 cells | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19 | Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida. |
| AID301052 | Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of e antigen HBsAg secretion | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19 | Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida. |
| AID301051 | Antiviral activity against HBV transfected Hep G2.2.15 cells assessed as inhibition of surface antigen HBsAg secretion | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19 | Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida. |
| AID301050 | Cytotoxicity against human Hep G2.2.15 cells | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19 | Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida. |
| AID301054 | Selectivity index, ratio of CC50 for human Hep G2.2.15 cells to IC50 for HBV e antigen secretion in HBV transfected Hep G2.2.15 cells | 2007 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19 | Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (21.32) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (33.33%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (66.67%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||