Compounds > daphnodorin b

Page last updated: 2024-11-06

daphnodorin b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

daphnodorin B: structure given in first source; isolated from the root and bark of Daphne odora [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Daphne	genus	A plant genus of the family THYMELAEACEAE. They are evergreen shrubs much cultivated in garden borders and rock gardens in mild climates. Members contain mezerein, flavonoids, and COUMARINS such as daphnetin and daphnin.[MeSH]	Thymelaeaceae	A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.[MeSH]
Daphne odora	species	[no description available]	Thymelaeaceae	A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.[MeSH]

Cross-References

ID Source	ID
PubMed CID	72427
CHEMBL ID	2273052
SCHEMBL ID	1229973
MeSH ID	M0155113

Synonyms (14)

Synonym
nsc698798
95733-02-1
[3,4-dihydro-3,5-dihydro-2,8-bis(4-hydroxyphenyl)-2h-furo[2,3-h]benzopyran-9-yl](2,4,5-trihydroxyphenyl)methanone, trans-(-)
daphnodorin b
[(2r,3s)-3,5-dihydroxy-2,8-bis(4-hydroxyphenyl)-3,4-dihydro-2h-furo[2,3-h]chromen-9-yl]-(2,4,6-trihydroxyphenyl)methanone
nsc-698798
methanone, (3,4-dihydro-3,5-dihydroxy-2,8-bis(4-hydroxyphenyl)-2h-furo(2,3-h)-l-benzopyran-9-yl)(2,4,6-trihydroxyphenyl)-, trans-(-)-
[(2r,3s)-3,5-dihydroxy-2,8-bis(4-hydroxyphenyl)-3,4-dihydro-2h-furo[2,3-h]chromen-9-yl](2,4,6-trihydroxyphenyl)methanone
CHEMBL2273052
SCHEMBL1229973
DTXSID50241941
HY-N10961
CS-0637794
AKOS040734025

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay ID	Title	Year	Journal	Article
AID1105482	Antifungal activity against Blumeria graminis inoculated in compound treated Triticum aestivum leaves assessed as protective value at 27 degC at 500 ppm by spraying method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105485	Antifungal activity against Phytophthora infestans inoculated in compound treated Lycopersicon esculentum MILL, leaves assessed as protective value at 27 degC at 500 ppm by spraying method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105483	Antifungal activity against Puccinia recondita inoculated in compound treated Triticum aestivum leaves assessed as protective value at 27 degC at 500 ppm by spraying method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105486	Antifungal activity against Rhizoctonia solani inoculated in compound treated Oryza sativa leaves assessed as protective value at 27 degC at 500 ppm by spraying method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105487	Antifungal activity against Magnaporthe oryzae inoculated in compound treated Oryza sativa leaves assessed as protective value at 27 degC at 500 ppm by spraying method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105474	Insecticidal activity against adult and eggs of Tetranychus urticae (two-spotted spider mite) assessed as mortality at 500 ppm sprayed onto organism at 25 to 27 degC measured after 5 days	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105484	Antifungal activity against Botryotinia fuckeliana inoculated in compound treated Pisum sativum var. arvense POIL. leaves assessed as protective value at 27 degC at 500 ppm by spraying method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105476	Insecticidal activity against adult Callosobruchus chinensis in compound treated ingenmame leaves assessed as mortality at 500 ppm at 25 to 27 degC measured after 5 days	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105475	Insecticidal activity against third-instar larvae of Nilaparvata lugens (brown planthopper) in compound treated Oriza sativa stem assessed as mortality at 500 ppm at 25 to 27 degC measured after 5 days by stem dip method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105477	Insecticidal activity against third-instar larvae Spodoptera litura in compound treated cabbage leaves assessed as mortality at 500 ppm at 25 to 27 degC measured after 5 days by leaf dip method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (14.29)	18.7374
1990's	3 (42.86)	18.2507
2000's	2 (28.57)	29.6817
2010's	1 (14.29)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.57

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.57 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.65 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.57)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.08	1	0	metal allergen; nickel group element atom; platinum group metal atom
daphnodorin a daphnodorin A: structure in first source; isolated from the root and bark of Daphne odora	8.09	5	0
daphnodorin c daphnodorin C: structure given in first source; isolated from the root and bark of Daphne odora	8.09	5	0
angiotensin ii Giapreza: injectable form of angiotensin II used to increase blood pressure in adult patients with septic or other distributive shock. Ile(5)-angiotensin II : An angiotensin II that acts on the central nervous system (PDB entry: 1N9V).	7	1	0	amino acid zwitterion; angiotensin II	human metabolite
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	7.08	1	0
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	1.99	1	0	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
12-hydroxy-5,8,10-heptadecatrienoic acid 12-hydroxy-5,8,10-heptadecatrienoic acid: metabolite of arachidonic acid in blood platelet suspension; RN given refers to cpd without isomeric designation	1.99	1	0	hydroxy polyunsaturated fatty acid; long-chain fatty acid; trienoic fatty acid	metabolite
12-hydroxy-5,8,10,14-eicosatetraenoic acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid: A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)	1.99	1	0

Condition	Indicated	Relationship Strength	Studies	Trials
Carcinoma, Lewis Lung A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.	0	2.03	1	0
Cancer of Lung [description not available]	0	2.03	1	0
Lung Neoplasms Tumors or cancer of the LUNG.	0	2.03	1	0