Compounds > daphnodorin a
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daphnodorin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Daphnodorin A is a complex diterpenoid compound isolated from the plant Daphne odora. Its unique chemical structure and potential biological activities have made it a target of interest for researchers. Studies have explored its synthesis, primarily using a combination of chemical reactions and natural product transformations. The compound has exhibited promising anticancer activity in laboratory settings, showing cytotoxicity against specific cancer cell lines. This has led to investigations into its potential therapeutic applications. However, further research is required to understand its detailed mechanisms of action, toxicity profile, and suitability for clinical use. Daphnodorin A's unique structure and biological activity make it a valuable model compound for studying natural product chemistry and drug discovery.'

daphnodorin A: structure in first source; isolated from the root and bark of Daphne odora [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
DaphnegenusA plant genus of the family THYMELAEACEAE. They are evergreen shrubs much cultivated in garden borders and rock gardens in mild climates. Members contain mezerein, flavonoids, and COUMARINS such as daphnetin and daphnin.[MeSH]ThymelaeaceaeA plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.[MeSH]
Daphne odoraspecies[no description available]ThymelaeaceaeA plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.[MeSH]

Cross-References

ID SourceID
PubMed CID72426
CHEMBL ID2273051
MeSH IDM0155112

Synonyms (8)

Synonym
[(2s)-5-hydroxy-2,8-bis(4-hydroxyphenyl)-3,4-dihydro-2h-furo[2,3-h]chromen-9-yl]-(2,4,6-trihydroxyphenyl)methanone
[3,4-dihydro-5-hydroxy-2,8-bis(4-hydroxyphenyl)-2h-furo[2,3-h]-1-benzopyran-9-yl](2,4,6-trihydroxyphenyl)methanone, (-)-
daphnodorin a
95733-03-2
methanone, (3,4-dihydro-5-hydroxy-2,8-bis(4-hydroxyphenyl)-2h-furo(2,3-h)-1-benzopyran-9-yl)(2,4,6-trihydroxyphenyl)-, (-)-
(-)-(3,4-dihydro-5-hydroxy-2,8-bis(4-hydroxyphenyl)-2h-furo(2,3-h)-1-benzopyran-9-yl)(2,4,6-trihydroxyphenyl)methanone
CHEMBL2273051
DTXSID10241942

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID1105485Antifungal activity against Phytophthora infestans inoculated in compound treated Lycopersicon esculentum MILL, leaves assessed as protective value at 27 degC at 500 ppm by spraying method1987Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9
Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105476Insecticidal activity against adult Callosobruchus chinensis in compound treated ingenmame leaves assessed as mortality at 500 ppm at 25 to 27 degC measured after 5 days1987Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9
Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105479Antifungal activity against Magnaporthe oryzae inoculated in compound treated Oryza sativa leaves assessed as protective value at 27 degC at 10 ppm by spraying method1987Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9
Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105480Antifungal activity against Magnaporthe oryzae inoculated in compound treated Oryza sativa leaves assessed as protective value at 27 degC at 50 ppm by spraying method1987Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9
Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105477Insecticidal activity against third-instar larvae Spodoptera litura in compound treated cabbage leaves assessed as mortality at 500 ppm at 25 to 27 degC measured after 5 days by leaf dip method1987Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9
Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105487Antifungal activity against Magnaporthe oryzae inoculated in compound treated Oryza sativa leaves assessed as protective value at 27 degC at 500 ppm by spraying method1987Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9
Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105475Insecticidal activity against third-instar larvae of Nilaparvata lugens (brown planthopper) in compound treated Oriza sativa stem assessed as mortality at 500 ppm at 25 to 27 degC measured after 5 days by stem dip method1987Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9
Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105474Insecticidal activity against adult and eggs of Tetranychus urticae (two-spotted spider mite) assessed as mortality at 500 ppm sprayed onto organism at 25 to 27 degC measured after 5 days1987Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9
Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105486Antifungal activity against Rhizoctonia solani inoculated in compound treated Oryza sativa leaves assessed as protective value at 27 degC at 500 ppm by spraying method1987Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9
Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105484Antifungal activity against Botryotinia fuckeliana inoculated in compound treated Pisum sativum var. arvense POIL. leaves assessed as protective value at 27 degC at 500 ppm by spraying method1987Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9
Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105481Antifungal activity against Magnaporthe oryzae inoculated in compound treated Oryza sativa leaves assessed as protective value at 27 degC at 200 ppm by spraying method1987Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9
Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105482Antifungal activity against Blumeria graminis inoculated in compound treated Triticum aestivum leaves assessed as protective value at 27 degC at 500 ppm by spraying method1987Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9
Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105483Antifungal activity against Puccinia recondita inoculated in compound treated Triticum aestivum leaves assessed as protective value at 27 degC at 500 ppm by spraying method1987Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9
Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105478Antifungal activity against Magnaporthe oryzae inoculated in compound treated Oryza sativa leaves assessed as residual effect on leaves at 27 degC at 500 ppm by spraying method1987Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9
Antifungal and insecticidal activities of daphnodorins A, B and C.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's4 (66.67)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.78 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.72 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
daphnodorin b
daphnodorin B: structure given in first source; isolated from the root and bark of Daphne odora		8.0950
daphnodorin c
daphnodorin C: structure given in first source; isolated from the root and bark of Daphne odora		8.0950
angiotensin ii
Giapreza: injectable form of angiotensin II used to increase blood pressure in adult patients with septic or other distributive shock. Ile(5)-angiotensin II : An angiotensin II that acts on the central nervous system (PDB entry: 1N9V).		2.420amino acid zwitterion;
angiotensin II		human metabolite
arachidonic acid
icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.		6.9910icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
12-hydroxy-5,8,10-heptadecatrienoic acid
12-hydroxy-5,8,10-heptadecatrienoic acid: metabolite of arachidonic acid in blood platelet suspension; RN given refers to cpd without isomeric designation		1.9910hydroxy polyunsaturated fatty acid;
long-chain fatty acid;
trienoic fatty acid		metabolite
12-hydroxy-5,8,10,14-eicosatetraenoic acid
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid: A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)		1.9910
ConditionIndicatedRelationship StrengthStudiesTrials
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		0210