Compounds > daphnodorin c

Page last updated: 2024-11-06

daphnodorin c

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

daphnodorin C: structure given in first source; isolated from the root and bark of Daphne odora [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Daphne	genus	A plant genus of the family THYMELAEACEAE. They are evergreen shrubs much cultivated in garden borders and rock gardens in mild climates. Members contain mezerein, flavonoids, and COUMARINS such as daphnetin and daphnin.[MeSH]	Thymelaeaceae	A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.[MeSH]
Daphne odora	species	[no description available]	Thymelaeaceae	A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.[MeSH]

Cross-References

ID Source	ID
PubMed CID	72428
CHEMBL ID	2273053
SCHEMBL ID	1229248
MeSH ID	M0155114

Synonyms (10)

Synonym
(2s,8s,9s)-4',5,6'-trihydroxy-2,8-bis(4-hydroxyphenyl)spiro[2,3,4,8-tetrahydrofuro[2,3-h]chromene-9,2'-benzofuran]-3'-one
daphnodorin c
[3',4'-dihydro-4,5',6-trihydroxy-2',8'-bis(4-hydroxyphenyl)spiro[benzofuran-2(3h),9'(8'h)-[2h]furo[2,3-h][1]benzopyran-3-one, (8'-s-cis)
95733-04-3
(2s,2's,8's)-4,5',6-trihydroxy-2',8'-bis(4-hydroxyphenyl)spiro[1-benzofuran-2,9'-2,3,4,8-tetrahydrofuro[2,3-h]chromene]-3-one
sprio(benzofuran-2(3h),9'(8'h)-(2h)furo(2,3-h)(1)benzopyran)-3-one, 3',4'-dihydro-4,5',6-trihydroxy-2',8'-bis(4-hydroxyphenyl)-, (8's-cis)-
CHEMBL2273053
SCHEMBL1229248
4,5',6-trihydroxy-2',8'-bis(4-hydroxyphenyl)-3',4'-dihydro-2'h,3h,8'h-spiro[1-benzofuran-2,9'-furo[2,3-h][1]benzopyran]-3-one
DTXSID60914831

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay ID	Title	Year	Journal	Article
AID1105487	Antifungal activity against Magnaporthe oryzae inoculated in compound treated Oryza sativa leaves assessed as protective value at 27 degC at 500 ppm by spraying method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105486	Antifungal activity against Rhizoctonia solani inoculated in compound treated Oryza sativa leaves assessed as protective value at 27 degC at 500 ppm by spraying method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105476	Insecticidal activity against adult Callosobruchus chinensis in compound treated ingenmame leaves assessed as mortality at 500 ppm at 25 to 27 degC measured after 5 days	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105482	Antifungal activity against Blumeria graminis inoculated in compound treated Triticum aestivum leaves assessed as protective value at 27 degC at 500 ppm by spraying method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105475	Insecticidal activity against third-instar larvae of Nilaparvata lugens (brown planthopper) in compound treated Oriza sativa stem assessed as mortality at 500 ppm at 25 to 27 degC measured after 5 days by stem dip method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105479	Antifungal activity against Magnaporthe oryzae inoculated in compound treated Oryza sativa leaves assessed as protective value at 27 degC at 10 ppm by spraying method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105483	Antifungal activity against Puccinia recondita inoculated in compound treated Triticum aestivum leaves assessed as protective value at 27 degC at 500 ppm by spraying method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105478	Antifungal activity against Magnaporthe oryzae inoculated in compound treated Oryza sativa leaves assessed as residual effect on leaves at 27 degC at 500 ppm by spraying method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105481	Antifungal activity against Magnaporthe oryzae inoculated in compound treated Oryza sativa leaves assessed as protective value at 27 degC at 200 ppm by spraying method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105485	Antifungal activity against Phytophthora infestans inoculated in compound treated Lycopersicon esculentum MILL, leaves assessed as protective value at 27 degC at 500 ppm by spraying method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105474	Insecticidal activity against adult and eggs of Tetranychus urticae (two-spotted spider mite) assessed as mortality at 500 ppm sprayed onto organism at 25 to 27 degC measured after 5 days	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105480	Antifungal activity against Magnaporthe oryzae inoculated in compound treated Oryza sativa leaves assessed as protective value at 27 degC at 50 ppm by spraying method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105484	Antifungal activity against Botryotinia fuckeliana inoculated in compound treated Pisum sativum var. arvense POIL. leaves assessed as protective value at 27 degC at 500 ppm by spraying method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
AID1105477	Insecticidal activity against third-instar larvae Spodoptera litura in compound treated cabbage leaves assessed as mortality at 500 ppm at 25 to 27 degC measured after 5 days by leaf dip method	1987	Chemical & pharmaceutical bulletin, Sep, Volume: 35, Issue:9	Antifungal and insecticidal activities of daphnodorins A, B and C.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (16.67)	18.7374
1990's	3 (50.00)	18.2507
2000's	1 (16.67)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.64

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.64 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.59 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.64)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
daphnodorin a daphnodorin A: structure in first source; isolated from the root and bark of Daphne odora	8.09	5	0
daphnodorin b daphnodorin B: structure given in first source; isolated from the root and bark of Daphne odora	8.09	5	0
angiotensin ii Giapreza: injectable form of angiotensin II used to increase blood pressure in adult patients with septic or other distributive shock. Ile(5)-angiotensin II : An angiotensin II that acts on the central nervous system (PDB entry: 1N9V).	7	1	0	amino acid zwitterion; angiotensin II	human metabolite
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	1.99	1	0	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
12-hydroxy-5,8,10-heptadecatrienoic acid 12-hydroxy-5,8,10-heptadecatrienoic acid: metabolite of arachidonic acid in blood platelet suspension; RN given refers to cpd without isomeric designation	1.99	1	0	hydroxy polyunsaturated fatty acid; long-chain fatty acid; trienoic fatty acid	metabolite
12-hydroxy-5,8,10,14-eicosatetraenoic acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid: A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)	1.99	1	0

Condition	Indicated	Relationship Strength	Studies	Trials
Airflow Obstruction, Chronic [description not available]	0	2.41	1	0
Innate Inflammatory Response [description not available]	0	2.41	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	0	7.41	1	0
Pulmonary Disease, Chronic Obstructive A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.	0	2.41	1	0