Page last updated: 2024-11-07

combretastatin b-1

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

combretastatin B-1: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135716
CHEMBL ID285152
SCHEMBL ID16915262
MeSH IDM0371895

Synonyms (14)

Synonym
nk47ts5h6v ,
unii-nk47ts5h6v
109971-64-4
3-methoxy-6-(2-(3,4,5-trimethoxyphenyl)ethyl)-1,2-benzenediol
1,2-benzenediol, 3-methoxy-6-(2-(3,4,5-trimethoxyphenyl)ethyl)-
nsc-601291
combretastatin b-1
CHEMBL285152
combretastatin b1
SCHEMBL16915262
DTXSID40149083
2',3'-dihydroxy-3,4,4',5-tetramethoxybibenzyl
Q5150957
1,2-benzenediol, 3-methoxy-6-[2-(3,4,5-trimethoxyphenyl)ethyl]-
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID338991Antimitotic activity in mouse L1210 cells assessed as increase in mitotic index at 2 to 7 times IC50 after 6 hrs relative to control
AID337714Inhibition of microtubule assembly by turbidimetry
AID338986Inhibition of microtubule assembly after 15 mins
AID338987Displacement of [3H]colchicine from tubulin at inhibitor and colchicine ratio 1:1 after 10 mins relative to control
AID376527Antibacterial activity against Neisseria gonorrhoeae by disk susceptibility test2000Journal of natural products, Jul, Volume: 63, Issue:7
Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1, 2-dihydroxy- 1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3' ',4' ',5' '-trimethoxyphenyl)-ethane.
AID338990Cytotoxicity against mouse L1210 cells after 24 hrs
AID338988Displacement of [3H]colchicine from tubulin at inhibitor and colchicine ratio 10:1 after 10 mins relative to control
AID376520Cytotoxicity against mouse P388 cells2000Journal of natural products, Jul, Volume: 63, Issue:7
Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1, 2-dihydroxy- 1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3' ',4' ',5' '-trimethoxyphenyl)-ethane.
AID147019Antimicrobial activity against Neisseria gonorrhoeae1999Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8
Antineoplastic agents. 410. Asymmetric hydroxylation of trans-combretastatin A-4.
AID337715Displacement of [3H]colchicine from tubulin after 10 mins relative to control
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.13 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]