Page last updated: 2024-12-08
combretastatin b-1
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
combretastatin B-1: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 135716 |
| CHEMBL ID | 285152 |
| SCHEMBL ID | 16915262 |
| MeSH ID | M0371895 |
Synonyms (14)
| Synonym |
|---|
| nk47ts5h6v , |
| unii-nk47ts5h6v |
| 109971-64-4 |
| 3-methoxy-6-(2-(3,4,5-trimethoxyphenyl)ethyl)-1,2-benzenediol |
| 1,2-benzenediol, 3-methoxy-6-(2-(3,4,5-trimethoxyphenyl)ethyl)- |
| nsc-601291 |
| combretastatin b-1 |
| CHEMBL285152 |
| combretastatin b1 |
| SCHEMBL16915262 |
| DTXSID40149083 |
| 2',3'-dihydroxy-3,4,4',5-tetramethoxybibenzyl |
| Q5150957 |
| 1,2-benzenediol, 3-methoxy-6-[2-(3,4,5-trimethoxyphenyl)ethyl]- |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (10)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID338991 | Antimitotic activity in mouse L1210 cells assessed as increase in mitotic index at 2 to 7 times IC50 after 6 hrs relative to control | |||
| AID337714 | Inhibition of microtubule assembly by turbidimetry | |||
| AID338986 | Inhibition of microtubule assembly after 15 mins | |||
| AID338987 | Displacement of [3H]colchicine from tubulin at inhibitor and colchicine ratio 1:1 after 10 mins relative to control | |||
| AID376527 | Antibacterial activity against Neisseria gonorrhoeae by disk susceptibility test | 2000 | Journal of natural products, Jul, Volume: 63, Issue:7 | Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1, 2-dihydroxy- 1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3' ',4' ',5' '-trimethoxyphenyl)-ethane. |
| AID338990 | Cytotoxicity against mouse L1210 cells after 24 hrs | |||
| AID338988 | Displacement of [3H]colchicine from tubulin at inhibitor and colchicine ratio 10:1 after 10 mins relative to control | |||
| AID376520 | Cytotoxicity against mouse P388 cells | 2000 | Journal of natural products, Jul, Volume: 63, Issue:7 | Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1, 2-dihydroxy- 1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3' ',4' ',5' '-trimethoxyphenyl)-ethane. |
| AID147019 | Antimicrobial activity against Neisseria gonorrhoeae | 1999 | Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8 | Antineoplastic agents. 410. Asymmetric hydroxylation of trans-combretastatin A-4. |
| AID337715 | Displacement of [3H]colchicine from tubulin after 10 mins relative to control | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.13
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.13) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (12.50%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (87.50%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||