Page last updated: 2024-12-04
carpronium
Description
Carpronium is a quaternary ammonium compound that acts as a centrally acting muscle relaxant. Its synthesis involves a multi-step process, starting with the reaction of 2-chloroethyldiethylamine with N-(2-hydroxyethyl)piperidine. Carpronium exerts its effects by inhibiting the release of acetylcholine at the neuromuscular junction. It is primarily used to treat spasticity associated with conditions such as multiple sclerosis and cerebral palsy. Carpronium is studied due to its potential therapeutic benefits in managing muscle spasticity. Its importance lies in its ability to improve mobility and reduce pain in patients with these conditions.'
carpronium: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
carpronium : A methyl ester resulting from the formal condensation of the carboxy group of 4-(trimethylammonio)butanoic acid with methanol. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 2582 |
| CHEMBL ID | 1896433 |
| CHEBI ID | 145653 |
| SCHEMBL ID | 195274 |
| MeSH ID | M0042186 |
Synonyms (18)
| Synonym |
|---|
| x6uk728glz , |
| unii-x6uk728glz |
| ammonium, (3-carboxypropyl)trimethyl-, methyl ester |
| carpronium |
| (4-methoxy-4-oxobutyl)-trimethylazanium |
| carpronium ion |
| 14075-13-9 |
| CHEBI:145653 |
| 4-methoxy-n,n,n-trimethyl-4-oxobutan-1-aminium |
| carpronium cation |
| CHEMBL1896433 |
| SCHEMBL195274 |
| carpronium [who-dd] |
| (3-carboxypropyl)trimethylammonium, methyl ester |
| DTXSID8048236 |
| NCGC00181355-02 |
| FT-0696767 |
| Q23731008 |
Research Excerpts
Effects
| Excerpt | Reference | Relevance |
|---|
| "Carpronium chloride has a chemical structure similar to that of acetylcholine; therefore, it exhibits both cholinergic and local vasodilatory activities." | ( Cholinergic crisis caused by ingesting topical carpronium chloride solution: A case report.
Amagasa, S; Endo, T; Kashiura, M; Kubota, Y; Moriya, T, 2021) | 1.6 |
| "Carpronium chloride has a chemical structure similar to that of acetylcholine; therefore, it exhibits both cholinergic and local vasodilatory activities." | ( Cholinergic crisis caused by ingesting topical carpronium chloride solution: A case report.
Amagasa, S; Endo, T; Kashiura, M; Kubota, Y; Moriya, T, 2021) | 1.6 |
Drug Classes (2)
| Class | Description |
|---|
| quaternary ammonium ion | A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups. |
| methyl ester | Any carboxylic ester resulting from the formal condensation of a carboxy group with methanol. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (10)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 29.55
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 29.55 (24.57) | | Research Supply Index | 2.40 (2.92) | | Research Growth Index | 4.80 (4.65) | | Search Engine Demand Index | 46.22 (26.88) | | Search Engine Supply Index | 3.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 1 (10.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (90.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |