Compounds > carpronium
Page last updated: 2024-12-04

carpronium

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Carpronium is a quaternary ammonium compound that acts as a centrally acting muscle relaxant. Its synthesis involves a multi-step process, starting with the reaction of 2-chloroethyldiethylamine with N-(2-hydroxyethyl)piperidine. Carpronium exerts its effects by inhibiting the release of acetylcholine at the neuromuscular junction. It is primarily used to treat spasticity associated with conditions such as multiple sclerosis and cerebral palsy. Carpronium is studied due to its potential therapeutic benefits in managing muscle spasticity. Its importance lies in its ability to improve mobility and reduce pain in patients with these conditions.'

carpronium: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

carpronium : A methyl ester resulting from the formal condensation of the carboxy group of 4-(trimethylammonio)butanoic acid with methanol. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID2582
CHEMBL ID1896433
CHEBI ID145653
SCHEMBL ID195274
MeSH IDM0042186

Synonyms (18)

Synonym
x6uk728glz ,
unii-x6uk728glz
ammonium, (3-carboxypropyl)trimethyl-, methyl ester
carpronium
(4-methoxy-4-oxobutyl)-trimethylazanium
carpronium ion
14075-13-9
CHEBI:145653
4-methoxy-n,n,n-trimethyl-4-oxobutan-1-aminium
carpronium cation
CHEMBL1896433
SCHEMBL195274
carpronium [who-dd]
(3-carboxypropyl)trimethylammonium, methyl ester
DTXSID8048236
NCGC00181355-02
FT-0696767
Q23731008

Research Excerpts

Effects

ExcerptReferenceRelevance
"Carpronium chloride has a chemical structure similar to that of acetylcholine; therefore, it exhibits both cholinergic and local vasodilatory activities."( Cholinergic crisis caused by ingesting topical carpronium chloride solution: A case report.
Amagasa, S; Endo, T; Kashiura, M; Kubota, Y; Moriya, T, 2021)		1.6
"Carpronium chloride has a chemical structure similar to that of acetylcholine; therefore, it exhibits both cholinergic and local vasodilatory activities."( Cholinergic crisis caused by ingesting topical carpronium chloride solution: A case report.
Amagasa, S; Endo, T; Kashiura, M; Kubota, Y; Moriya, T, 2021)		1.6
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
quaternary ammonium ionA derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.
methyl esterAny carboxylic ester resulting from the formal condensation of a carboxy group with methanol.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (40.00)18.7374
1990's0 (0.00)18.2507
2000's3 (30.00)29.6817
2010's1 (10.00)24.3611
2020's2 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.55

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index29.55 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index46.22 (26.88)
Search Engine Supply Index3.00 (0.95)

This Compound (29.55)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (10.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gamma-aminobutyric acid
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.		3.690amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
menthol
Menthol: A monoterpene cyclohexanol produced from mint oils.		7.4110p-menthane monoterpenoid;
secondary alcohol		volatile oil component
mazindol
Mazindol: Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.		1.9610organic molecular entity
minoxidil
Minoxidil: A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371). minoxidil : A pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6.		7.4110dialkylarylamine;
tertiary amino compound
cepharanthine
cepharanthine: isoquinoline alkaloid from tubers of STEPHANIA; stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation. cepharanthine : A bisbenzylisoquinoline alkaloid from tubers of Stephania; stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation.		2.0110bisbenzylisoquinoline alkaloid;
isoquinolines
deuterium
Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.		6.9510dihydrogen
squaric acid dibutyl ester
squaric acid dibutyl ester : A cyclic ketone and diether that is a dibutyl ether derivative of squaric acid.		2.0110cyclic ketone;
diether		allergen;
immunological adjuvant
deoxyglucose
Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.. deoxyglucose : A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen.		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Altered Level of Consciousness
[description not available]		02.3110
Flushing
A transient reddening of the face that may be due to fever, certain drugs, exertion, or stress.		02.3110
Alopecia Circumscripta
[description not available]		02.0110
Alopecia Areata
Loss of scalp and body hair involving microscopically inflammatory patchy areas.		02.0110
Dermatoses
[description not available]		02.0110
Skin Diseases
Diseases involving the DERMIS or EPIDERMIS.		02.0110