beta-aminoarteether-maleate has been researched along with Breast-Neoplasms* in 1 studies
1 other study(ies) available for beta-aminoarteether-maleate and Breast-Neoplasms
| Article | Year |
|---|---|
A novel derivative of artemisinin inhibits cell proliferation and metastasis via down-regulation of cathepsin K in breast cancer.
Breast cancer is one of the main diagnosis cancers annually worldwide. It is difficult to thorough cure due to drug resistance and the high possibility of metastasis. SM934 is a novel water-soluble artemisinin analog, and has been reported to have a promising therapeutic effect on multiple autoimmune diseases. In this study, SM934 was combined with Testosterone, which is related to prostate cancer, and the reaction product was SM934-Testosterone. We aimed to explore whether SM934, Testosterone and SM934-Testosterone could inhibit tumorigenesis and metastasis of breast cancer cells. Moreover, the mechanism also remains to be clarified. The results of our study showed that among the three compounds, only SM934-Testosterone treatment could lead to the suppression of cell proliferation and metastasis with IC Topics: Apoptosis; Artemisinins; bcl-X Protein; Breast Neoplasms; Cathepsin K; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Down-Regulation; Humans; Neoplasm Metastasis; Testosterone | 2019 |