Page last updated: 2024-12-07
azepinomycin
Description
azepinomycin: from Streptomyces sp. MF718-03; structure given in first source; RN given from Chem Abst Index Guide 1982-6 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
Synonyms (10)
| Synonym |
|---|
| 89354-15-4 |
| 6-hydroxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(1h)-one |
| azepinomycin |
| bdbm50401837 |
| CHEMBL2203870 , |
| 4,5,6,7-tetrahydro-6-hydroxy-3h-imidazo-(4,5e)(1,4)diazepin-8-one |
| imidazo(4,5-e)(1,4)diazepin-8(1h)-one, 4,5,6,7-tetrahydro-6-hydroxy- |
| DTXSID901008765 |
| 3,4,5,6-tetrahydroimidazo[4,5-e][1,4]diazepine-6,8-diol |
| STARBLD0002815 |
Protein Targets (1)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|
| Guanine deaminase | Homo sapiens (human) | IC50 (µMol) | 5.0000 | 5.0000 | 5.0000 | 5.0000 | AID717436 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Biological Processes (9)
Molecular Functions (2)
Ceullar Components (1)
Bioassays (3)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID765125 | Inhibition of rabbit liver guanase assessed as inhibition of guanine hydrolysis by Lineweaver-Burk plot method | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Analogs of iso-azepinomycin as potential transition-state analog inhibitors of guanase: synthesis, biochemical screening, and structure-activity correlations of various selectively substituted imidazo[4,5-e][1,4]diazepines. |
| AID717436 | Inhibition of guanase | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23
| Investigations into specificity of azepinomycin for inhibition of guanase: discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues. |
| AID717437 | Competitive inhibition of rabbit liver guanase assessed as guanine hydrolysis rate by Lineweaver-Burk plot method | 2012 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23
| Investigations into specificity of azepinomycin for inhibition of guanase: discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (9)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.80
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.80 (24.57) | | Research Supply Index | 2.40 (2.92) | | Research Growth Index | 5.20 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |