Compounds > azepinomycin
Page last updated: 2024-12-07

azepinomycin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

azepinomycin: from Streptomyces sp. MF718-03; structure given in first source; RN given from Chem Abst Index Guide 1982-6 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID128950
CHEMBL ID2203870
MeSH IDM0153542

Synonyms (10)

Synonym
89354-15-4
6-hydroxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(1h)-one
azepinomycin
bdbm50401837
CHEMBL2203870 ,
4,5,6,7-tetrahydro-6-hydroxy-3h-imidazo-(4,5e)(1,4)diazepin-8-one
imidazo(4,5-e)(1,4)diazepin-8(1h)-one, 4,5,6,7-tetrahydro-6-hydroxy-
DTXSID901008765
3,4,5,6-tetrahydroimidazo[4,5-e][1,4]diazepine-6,8-diol
STARBLD0002815
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Guanine deaminaseHomo sapiens (human)IC50 (µMol)5.00005.00005.00005.0000AID717436
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (9)

Processvia Protein(s)Taxonomy
allantoin metabolic processGuanine deaminaseHomo sapiens (human)
nucleobase-containing compound metabolic processGuanine deaminaseHomo sapiens (human)
guanine catabolic processGuanine deaminaseHomo sapiens (human)
deoxyguanosine catabolic processGuanine deaminaseHomo sapiens (human)
nervous system developmentGuanine deaminaseHomo sapiens (human)
amide catabolic processGuanine deaminaseHomo sapiens (human)
GMP catabolic processGuanine deaminaseHomo sapiens (human)
dGMP catabolic processGuanine deaminaseHomo sapiens (human)
guanine metabolic processGuanine deaminaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
zinc ion bindingGuanine deaminaseHomo sapiens (human)
guanine deaminase activityGuanine deaminaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
cytosolGuanine deaminaseHomo sapiens (human)
cytosolGuanine deaminaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID765125Inhibition of rabbit liver guanase assessed as inhibition of guanine hydrolysis by Lineweaver-Burk plot method2013Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
Analogs of iso-azepinomycin as potential transition-state analog inhibitors of guanase: synthesis, biochemical screening, and structure-activity correlations of various selectively substituted imidazo[4,5-e][1,4]diazepines.
AID717436Inhibition of guanase2012Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23
Investigations into specificity of azepinomycin for inhibition of guanase: discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues.
AID717437Competitive inhibition of rabbit liver guanase assessed as guanine hydrolysis rate by Lineweaver-Burk plot method2012Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23
Investigations into specificity of azepinomycin for inhibition of guanase: discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (11.11)18.7374
1990's3 (33.33)18.2507
2000's1 (11.11)29.6817
2010's4 (44.44)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.80 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index5.20 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
imidazole
imidazole: RN given refers to parent cpd. 1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.		2.0810imidazole
coformycin
[no description available]		2.0710coformycinsEC 3.5.4.4 (adenosine deaminase) inhibitor
pentostatin
Pentostatin: A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.. pentostatin : A member of the class of coformycins that is coformycin in which the hydroxy group at position 2' is replaced with a hydrogen. It is a drug used for the treatment of hairy cell leukaemia.		2.0710coformycinsantimetabolite;
antineoplastic agent;
Aspergillus metabolite;
bacterial metabolite;
EC 3.5.4.4 (adenosine deaminase) inhibitor
stilbenes
Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.		1.9810stilbene
ConditionIndicatedRelationship StrengthStudiesTrials