Page last updated: 2024-11-13
azd9164
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Description
AZD9164: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 44517831 |
| CHEMBL ID | 1921904 |
| SCHEMBL ID | 524071 |
| MeSH ID | M0571711 |
Synonyms (18)
| Synonym |
|---|
| bdbm50419505 |
| azd 9164 |
| CHEMBL1921904 , |
| azd-9164 |
| j3.232.015e , |
| azd9164 |
| SCHEMBL524071 |
| 1-azoniabicyclo(2.2.2)octane, 1-(2-(4-fluorophenyl)ethyl)-3-((2s)-1-oxo-2-phenyl-2-(1-piperidinyl)propoxy)-, (3r)- |
| 1034978-04-5 |
| azd 9164 [who-dd] |
| 977LWC4O5D , |
| 1-(4-fluorophenethyl)-3.beta.-((s)-2-phenyl-2-(1-piperidinyl)propionyloxy)quinuclidinium |
| unii-977lwc4o5d |
| 1-(4-fluorophenethyl)-3beta-((s)-2-phenyl-2-(1-piperidinyl)propionyloxy)quinuclidinium |
| DB12115 |
| (r)-1-(4-fluorophenethyl)-3-(((s)-2-phenyl-2-(piperidin-1-yl)propanoyl)oxy)quinuclidin-1-ium |
| Q27271972 |
| STARBLD0042846 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (1)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 (µMol) | 0.0002 | 0.0001 | 1.0104 | 9.9280 | AID631741 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (21)
Molecular Functions (6)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| phosphatidylinositol phospholipase C activity | Muscarinic acetylcholine receptor M3 | Homo sapiens (human) |
| protein binding | Muscarinic acetylcholine receptor M3 | Homo sapiens (human) |
| G protein-coupled acetylcholine receptor activity | Muscarinic acetylcholine receptor M3 | Homo sapiens (human) |
| signaling receptor activity | Muscarinic acetylcholine receptor M3 | Homo sapiens (human) |
| acetylcholine binding | Muscarinic acetylcholine receptor M3 | Homo sapiens (human) |
| G protein-coupled serotonin receptor activity | Muscarinic acetylcholine receptor M3 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Ceullar Components (7)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| endoplasmic reticulum membrane | Muscarinic acetylcholine receptor M3 | Homo sapiens (human) |
| plasma membrane | Muscarinic acetylcholine receptor M3 | Homo sapiens (human) |
| basal plasma membrane | Muscarinic acetylcholine receptor M3 | Homo sapiens (human) |
| basolateral plasma membrane | Muscarinic acetylcholine receptor M3 | Homo sapiens (human) |
| postsynaptic membrane | Muscarinic acetylcholine receptor M3 | Homo sapiens (human) |
| synapse | Muscarinic acetylcholine receptor M3 | Homo sapiens (human) |
| plasma membrane | Muscarinic acetylcholine receptor M3 | Homo sapiens (human) |
| dendrite | Muscarinic acetylcholine receptor M3 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Bioassays (11)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID631746 | Antagonist potency at M3 receptor in Dunkin Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contraction after 1 hr by organ-bath technique | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631753 | Selectivity of the compound for recombinant human M3 receptor over recombinant human M2 receptor | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631752 | Therapeutic index, ratio of EC50 for inhibition of pilocarpine-induced salivation in intranasally dosed guinea pig to ED80 for bronchoprotection activity in intratracheally dosed Dunkin Hartley guinea pig | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631748 | Bronchoprotection activity in intratracheally dosed Dunkin Hartley guinea pig assessed as inhibition of methacholine-induced bronchoconstriction measured at 2 hrs post treatment | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631743 | Intrinsic clearance in human liver microsomes | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631744 | Plasma protein binding in human | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631754 | Bronchoprotection activity in Dunkin Hartley guinea pig assessed as time of action for inhibition of methacholine-induced bronchoconstriction at ED80 administered intratracheally | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631751 | Inhibition of pilocarpine-induced salivation in intranasally dosed guinea pig after 4 hrs measured for a period of 15 mins | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631741 | Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631747 | Half life in guinea pig lungs at 1 ug/kg administered intratracheally | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631750 | Bronchoprotection activity in Dunkin Hartley guinea pig assessed as inhibition of methacholine-induced bronchoconstriction at ED80 administered intratracheally measured at 18 hrs post treatment | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24 | The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (4)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (40.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 3 (60.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||