| Assay ID | Title | Year | Journal | Article |
|---|
| AID631746 | Antagonist potency at M3 receptor in Dunkin Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contraction after 1 hr by organ-bath technique | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631753 | Selectivity of the compound for recombinant human M3 receptor over recombinant human M2 receptor | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631752 | Therapeutic index, ratio of EC50 for inhibition of pilocarpine-induced salivation in intranasally dosed guinea pig to ED80 for bronchoprotection activity in intratracheally dosed Dunkin Hartley guinea pig | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631748 | Bronchoprotection activity in intratracheally dosed Dunkin Hartley guinea pig assessed as inhibition of methacholine-induced bronchoconstriction measured at 2 hrs post treatment | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631743 | Intrinsic clearance in human liver microsomes | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631744 | Plasma protein binding in human | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631754 | Bronchoprotection activity in Dunkin Hartley guinea pig assessed as time of action for inhibition of methacholine-induced bronchoconstriction at ED80 administered intratracheally | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631751 | Inhibition of pilocarpine-induced salivation in intranasally dosed guinea pig after 4 hrs measured for a period of 15 mins | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631741 | Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631747 | Half life in guinea pig lungs at 1 ug/kg administered intratracheally | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| AID631750 | Bronchoprotection activity in Dunkin Hartley guinea pig assessed as inhibition of methacholine-induced bronchoconstriction at ED80 administered intratracheally measured at 18 hrs post treatment | 2011 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 21, Issue:24
| The discovery of AZD9164, a novel muscarinic M3 antagonist. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |