Page last updated: 2024-12-11

awd 12-281

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

AWD 12-281: phosphodiesterase 4 inhibitor [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	6918428
CHEMBL ID	3218685
SCHEMBL ID	155120
MeSH ID	M0444396

Synonyms (30)

Synonym
awd-12-281
gw-842470
gsk-842470
awd 12-281
n-(3,5-dichloropyrid-4-yl)-(1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl)glyoxylic acid amide
n-(3,5-dichloropyridin-4-yl)-2-[1-[(4-fluorophenyl)methyl]-5-hydroxyindol-3-yl]-2-oxoacetamide
gsk 842470
257892-33-4
gw 842470
550671j24d ,
unii-550671j24d
247584-20-9
1h-indole-3-acetamide, n-(3,5-dichloro-4-pyridinyl)-1-((4-fluorophenyl)methyl)-5-hydroxy-.alpha.-oxo-
CHEMBL3218685
AKOS022178805
n-(3,5-dichloropyridin-4-yl)-2-[1-(4-fluorobenzyl)-5-hydroxyindol-3-yl]-2 -oxoacetamide
n-(3,5-dichloropyridin-4-yl)-2-[1-(4-fluorobenzyl)-5-hydroxyindol-3-yl]-2-oxoacetamide
n-(3,5-dichloropyridin-4-yl)-2-[1-(4-fluorobenzyl)-5-hydroxyindol-3yl]-2-oxoacetamide
DPHDSIQHVGSITN-UHFFFAOYSA-N
n-(3,5-dichloropyridin-4-yl)-2-[1-(4-fluorobenzyl)-5-hydroxyindol-3-yl]2-oxoacetamide
SCHEMBL155120
DTXSID60180453
awd12-281
awd 12-281; awd12-281; unii-550671j24d; gsk 842470; gsk 842470; gsk-842470
BCP12446
awd 12-281; gsk 842470
Q27261253
n-(3,5-dichloro-pyridin-4-yl)-2-[1-(4-fluoro-benzyl)-5-hydroxy-1h-indol-3-yl]-2-oxo-acetamide
A857629
n-(3,5-dichloropyridin-4-yl)-2-[1-(4-fluorobenzyl)-5-hydroxy-1h-indol-3-yl]-2-oxo-acetamide

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.46

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	17.46 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.36 (4.65)
Search Engine Demand Index	10.37 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (17.46)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (28.57%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (71.43%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
toluene methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.	2.01	1	methylbenzene; toluenes; volatile organic compound	cholinergic antagonist; fuel additive; neurotoxin; non-polar solvent
alpha-aminopyridine alpha-aminopyridine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #485. aminopyridine : Compounds containing a pyridine skeleton substituted by one or more amine groups.	4.32	3
toluene 2,4-diisocyanate Toluene 2,4-Diisocyanate: Skin irritant and allergen used in the manufacture of polyurethane foams and other elastomers.. toluene 2,4-diisocyanate : A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.	2.01	1	toluene meta-diisocyanate	allergen; hapten
cilomilast [no description available]	4.03	4	methoxybenzenes
roflumilast [no description available]	4.32	3	aromatic ether; benzamides; chloropyridine; cyclopropanes; organofluorine compound	anti-asthmatic drug; phosphodiesterase IV inhibitor
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	3.12	1

Condition	Relationship Strength	Studies
Eosinophilia, Tropical [description not available]	2.01	1
Disease, Pulmonary [description not available]	2.01	1
Emesis [description not available]	2.01	1
Eosinophilia Abnormal increase of EOSINOPHILS in the blood, tissues or organs.	2.01	1
Lung Diseases Pathological processes involving any part of the LUNG.	2.01	1
Vomiting The forcible expulsion of the contents of the STOMACH through the MOUTH.	2.01	1
Allergic Contact Dermatitis [description not available]	2.71	3
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	3.63	3
Innate Inflammatory Response [description not available]	4.1	3
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	4.1	3
Dermatitis, Allergic Contact A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.	2.71	3
Polyps Discrete abnormal tissue masses that protrude into the lumen of the DIGESTIVE TRACT or the RESPIRATORY TRACT. Polyps can be spheroidal, hemispheroidal, or irregular mound-shaped structures attached to the MUCOUS MEMBRANE of the lumen wall either by a stalk, pedunculus, or by a broad base.	2.02	1
Airflow Obstruction, Chronic [description not available]	3.81	2
Pulmonary Disease, Chronic Obstructive A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.	3.81	2
Eczema, Atopic [description not available]	2.94	1
Palmoplantaris Pustulosis [description not available]	2.94	1
Dermatitis, Atopic A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.	2.94	1
Psoriasis A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.	2.94	1
Respiratory Tract Diseases Diseases involving the RESPIRATORY SYSTEM.	2.94	1
Anasarca [description not available]	2.01	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.01	1

chemdatabank.com