amphidinolide B1: from Amphidinium sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 21773232 |
CHEMBL ID | 505471 |
MeSH ID | M0172242 |
Synonym |
---|
smr001338806 |
MLS002320521 , |
amphidinolide b1 |
CHEMBL505471 |
amphidinolide b |
(1s,3r,6e,8r,10s,13r,14s,15r,17s,20e,24e,26s)-8,10,13,14-tetrahydroxy-3,7,8,15,17,20-hexamethyl-5-methylene-18,27-dioxabicyclo[24.1.0]heptacosa-6,20,24-triene-12,19-dione |
(1s,3r,6e,8r,10s,13r,14s,15r,17s,20e,24e,26s)-8,10,13,14-tetrahydroxy-3,7,8,15,17,20-hexamethyl-5-methylidene-18,27-dioxabicyclo[24.1.0]heptacosa-6,20,24-triene-12,19-dione |
(1s,3r,6e,8r,10s,13r,14s,15r,17s,20e,24e,26s)-8,10,13,14-tetrahydroxy-3,7,8,15,17,20-hexamethyl-5-methylene-18,27-dioxabicyclo[24.1.0]heptacosa-6,20,24-triene-12,19-quinone |
(1s,3r,6e,8r,10s,13r,14s,15r,17s,20e,24e,26s)-3,7,8,15,17,20-hexamethyl-5-methylidene-8,10,13,14-tetrakis(oxidanyl)-18,27-dioxabicyclo[24.1.0]heptacosa-6,20,24-triene-12,19-dione |
bdbm67029 |
cid_21773232 |
(1s,2e,6e,10s,12r,13s,14r,17s,19r,20e,24r,26s)-13,14,17,19-tetrahydroxy-7,10,12,19,20,24-hexamethyl-22-methylidene-9,27-dioxabicyclo[24.1.0]heptacosa-2,6,20-triene-8,15-dione |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 7.9433 | 0.0447 | 17.8581 | 100.0000 | AID485341 |
ATAD5 protein, partial | Homo sapiens (human) | Potency | 0.0580 | 0.0041 | 10.8903 | 31.5287 | AID504467 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Chain A, BCL-2-RELATED PROTEIN A1 | Homo sapiens (human) | EC50 (µMol) | 350.0000 | 8.0570 | 121.1218 | 338.0000 | AID2765 |
bcl-2-like protein 11 isoform 1 | Homo sapiens (human) | EC50 (µMol) | 350.0000 | 8.0570 | 121.1218 | 338.0000 | AID2765 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Chain A, BCL-2-RELATED PROTEIN A1 | Homo sapiens (human) | AC50 | 350.0000 | 0.9200 | 95.9176 | 498.8000 | AID449754; AID449755; AID449757 |
Bcl-2-like protein 11 | Homo sapiens (human) | AC50 | 350.0000 | 9.8410 | 85.8882 | 287.1000 | AID449757 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Process | via Protein(s) | Taxonomy |
---|---|---|
protein binding | Bcl-2-like protein 11 | Homo sapiens (human) |
microtubule binding | Bcl-2-like protein 11 | Homo sapiens (human) |
protein kinase binding | Bcl-2-like protein 11 | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Process | via Protein(s) | Taxonomy |
---|---|---|
mitochondrial outer membrane | Bcl-2-like protein 11 | Homo sapiens (human) |
cytosol | Bcl-2-like protein 11 | Homo sapiens (human) |
endomembrane system | Bcl-2-like protein 11 | Homo sapiens (human) |
Bcl-2 family protein complex | Bcl-2-like protein 11 | Homo sapiens (human) |
mitochondrion | Bcl-2-like protein 11 | Homo sapiens (human) |
[Information is prepared from geneontology information from the June-17-2024 release] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 5 (71.43) | 29.6817 |
2010's | 2 (28.57) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.19) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 7 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |