Page last updated: 2024-11-08

5-methylxanthen-9-one-4-acetic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

5-methylxanthen-9-one-4-acetic acid: RN given refers to parent cpd; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID386023
CHEMBL ID29035
SCHEMBL ID9381286
MeSH IDM0183543

Synonyms (15)

Synonym
9h-xanthene-4-acetic acid, 5-methyl-9-oxo-
117570-47-5
5-methylxanthen-9-one-4-acetic acid
5-methylxanthenone-4-acetic acid
5-mexaa
5-me-xaa
5-methylxanthanone acetic acid
nsc677591
2-(5-methyl-9-oxo-xanthen-4-yl)acetic acid
NCI60_027675
CHEMBL29035
2-(5-methyl-9-oxoxanthen-4-yl)acetic acid
9h-xanthene-4-aceticacid, 5-methyl-9-oxo-
SCHEMBL9381286
DTXSID00151824
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID154743Inhibition of 10e6 P388 leukemic cells in mice, intraperitoneal administration1989Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo.
AID154732The average percentage increase in the lifespan of P388 leukemic mice, when compound was administered intraperitoneally1989Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo.
AID127211Antitumor activity against the subcutaneously implanted C38 colon tumor in mice.1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids.
AID201890Activity against colon adenocarcinoma C38 tumor in mice, after intraperitoneal administration at optimal dose1989Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo.
AID201899Inhibition of colon adenocarcinoma C38 tumor growth in mice, intraperitoneal administration1989Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo.
AID43490Percent necrosis activity against subcutaneous C38 colon tumor cells in vivo1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Potential antitumor agents. 60. Relationships between structure and in vivo colon 38 activity for 5-substituted 9-oxoxanthene-4-acetic acids.
AID43494Optimal dose 24 hr after intraperitoneal administration against C38 colon tumor cells in mice.1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
Potential antitumor agents. 60. Relationships between structure and in vivo colon 38 activity for 5-substituted 9-oxoxanthene-4-acetic acids.
AID201897Ability of compound (45 mg/kg, q7dx2) to inhibit growth of Sc colon 38 tumor cells in mice1989Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo.
AID133480Minimum dose required when administered intraperitoneally in mice as the sodium salt in water in a single dose. 1991Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's4 (80.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.09

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.09 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.88 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.09)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]