Page last updated: 2024-12-08
5-methylxanthen-9-one-4-acetic acid
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
5-methylxanthen-9-one-4-acetic acid: RN given refers to parent cpd; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 386023 |
| CHEMBL ID | 29035 |
| SCHEMBL ID | 9381286 |
| MeSH ID | M0183543 |
Synonyms (15)
| Synonym |
|---|
| 9h-xanthene-4-acetic acid, 5-methyl-9-oxo- |
| 117570-47-5 |
| 5-methylxanthen-9-one-4-acetic acid |
| 5-methylxanthenone-4-acetic acid |
| 5-mexaa |
| 5-me-xaa |
| 5-methylxanthanone acetic acid |
| nsc677591 |
| 2-(5-methyl-9-oxo-xanthen-4-yl)acetic acid |
| NCI60_027675 |
| CHEMBL29035 |
| 2-(5-methyl-9-oxoxanthen-4-yl)acetic acid |
| 9h-xanthene-4-aceticacid, 5-methyl-9-oxo- |
| SCHEMBL9381286 |
| DTXSID00151824 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (9)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID154743 | Inhibition of 10e6 P388 leukemic cells in mice, intraperitoneal administration | 1989 | Journal of medicinal chemistry, Apr, Volume: 32, Issue:4 | Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo. |
| AID154732 | The average percentage increase in the lifespan of P388 leukemic mice, when compound was administered intraperitoneally | 1989 | Journal of medicinal chemistry, Apr, Volume: 32, Issue:4 | Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo. |
| AID127211 | Antitumor activity against the subcutaneously implanted C38 colon tumor in mice. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids. |
| AID201890 | Activity against colon adenocarcinoma C38 tumor in mice, after intraperitoneal administration at optimal dose | 1989 | Journal of medicinal chemistry, Apr, Volume: 32, Issue:4 | Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo. |
| AID201899 | Inhibition of colon adenocarcinoma C38 tumor growth in mice, intraperitoneal administration | 1989 | Journal of medicinal chemistry, Apr, Volume: 32, Issue:4 | Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo. |
| AID43490 | Percent necrosis activity against subcutaneous C38 colon tumor cells in vivo | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Potential antitumor agents. 60. Relationships between structure and in vivo colon 38 activity for 5-substituted 9-oxoxanthene-4-acetic acids. |
| AID43494 | Optimal dose 24 hr after intraperitoneal administration against C38 colon tumor cells in mice. | 1990 | Journal of medicinal chemistry, May, Volume: 33, Issue:5 | Potential antitumor agents. 60. Relationships between structure and in vivo colon 38 activity for 5-substituted 9-oxoxanthene-4-acetic acids. |
| AID201897 | Ability of compound (45 mg/kg, q7dx2) to inhibit growth of Sc colon 38 tumor cells in mice | 1989 | Journal of medicinal chemistry, Apr, Volume: 32, Issue:4 | Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo. |
| AID133480 | Minimum dose required when administered intraperitoneally in mice as the sodium salt in water in a single dose. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 13.09
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.09) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||