Compounds > 4-phospho-d-erythronohydroxamic acid
Page last updated: 2024-09-27

4-phospho-d-erythronohydroxamic acid

Cross-References

ID SourceID
PubMed CID449303
CHEMBL ID116018
SCHEMBL ID2219243
MeSH IDM0508452

Synonyms (17)

Synonym
phosphoric acid mono-((1r,3r)-2,3-dihydroxy-3-hydroxycarbamoyl-propyl) ester
bdbm50148767
2,3-dihydroxy-4-(hydroxyamino)-4-oxobutyl dihydrogen phosphate
4-phospho-d-erythronohydroxamic acid
RES ,
DB04496 ,
2BES
[(2r,3r)-2,3-dihydroxy-4-(hydroxyamino)-4-oxobutyl] dihydrogen phosphate
CHEMBL116018 ,
718599-64-5
SCHEMBL2219243
DTXSID10332304
(2r,3r)-2,3-dihydroxy-4-(hydroxyamino)-4-oxobutyl dihydrogen phosphate
PD059244
(2r,3r)-2,3-dihydroxy-4-(hydroxyamino)-4-oxobutyldihydrogenphosphate
1310908-09-8
rel-(2r,3r)-2,3-dihydroxy-4-(hydroxyamino)-4-oxobutyl dihydrogen phosphate

Protein Targets (5)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
6-phosphogluconate dehydrogenase, decarboxylatingOvis aries (sheep)Ki2.54002.54002.54002.5400AID492275
6-phosphogluconate dehydrogenase, decarboxylatingHomo sapiens (human)Ki1.27500.01002.74508.3000AID7236; AID7238
6-phosphogluconate dehydrogenase, decarboxylating Trypanosoma brucei brucei TREU927Ki0.01000.01000.01000.0100AID594837
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (4)

Processvia Protein(s)Taxonomy
pentose-phosphate shunt6-phosphogluconate dehydrogenase, decarboxylatingHomo sapiens (human)
pentose-phosphate shunt, oxidative branch6-phosphogluconate dehydrogenase, decarboxylatingHomo sapiens (human)
pentose biosynthetic process6-phosphogluconate dehydrogenase, decarboxylatingHomo sapiens (human)
D-gluconate catabolic process6-phosphogluconate dehydrogenase, decarboxylatingHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
phosphogluconate dehydrogenase (decarboxylating) activity6-phosphogluconate dehydrogenase, decarboxylatingHomo sapiens (human)
NADP binding6-phosphogluconate dehydrogenase, decarboxylatingHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
nucleus6-phosphogluconate dehydrogenase, decarboxylatingHomo sapiens (human)
cytosol6-phosphogluconate dehydrogenase, decarboxylatingHomo sapiens (human)
extracellular exosome6-phosphogluconate dehydrogenase, decarboxylatingHomo sapiens (human)
cytosol6-phosphogluconate dehydrogenase, decarboxylatingHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID215359In vitro antiparasitic activity was determined against Trypanosoma brucei2004Journal of medicinal chemistry, Jun-17, Volume: 47, Issue:13
Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues.
AID7236Inhibition constant against 6-phosphogluconate dehydrogenase of Trypanosoma brucei expressed in Escherichia coli2004Journal of medicinal chemistry, Jun-17, Volume: 47, Issue:13
Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues.
AID492275Inhibition of sheep 6PGDH expressed in Escherichia coli by spectroscopy2010Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase.
AID594837Inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase2011Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9
Enediol mimics as inhibitors of the D-arabinose 5-phosphate isomerase (KdsD) from Francisella tularensis.
AID7238Inhibition constant against 6-phosphogluconate dehydrogenase of sheep liver2004Journal of medicinal chemistry, Jun-17, Volume: 47, Issue:13
Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues.
AID229393Selectivity ratio of inhibition constant of compound against 6-phosphogluconate dehydrogenase of sheep to 6-phosphogluconate dehydrogenase of Trypanosoma brucei2004Journal of medicinal chemistry, Jun-17, Volume: 47, Issue:13
Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues.
AID1693212Competitive inhibition of recombinant poly-His-tagged Trypanosoma cruzi Ribose 5-phosphate isomerase type B expressed in Escherichia coli BL21 codon plus (DE3) using ribose 5-phosphate as substrate
AID158531In vitro antiparasitic activity against Plasmodium falciparum2004Journal of medicinal chemistry, Jun-17, Volume: 47, Issue:13
Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues.
AID594838Inhibition of Mycobacterium tuberculosis rpiB2011Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9
Enediol mimics as inhibitors of the D-arabinose 5-phosphate isomerase (KdsD) from Francisella tularensis.
AID213662In vitro antiparasitic activity was determined against Trypanosoma cruzi2004Journal of medicinal chemistry, Jun-17, Volume: 47, Issue:13
Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues.
AID99666In vitro cytotoxic activity against L6 cells2004Journal of medicinal chemistry, Jun-17, Volume: 47, Issue:13
Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues.
AID1126501Binding affinity to Pseudomonas aeruginosa KdsD expressed Escherichia coli at 5 mM after 2 to 3 days by STD-NMR analysis2014Bioorganic & medicinal chemistry, Apr-15, Volume: 22, Issue:8
Arabinose 5-phosphate isomerase as a target for antibacterial design: studies with substrate analogues and inhibitors.
AID492273Inhibition of Trypanosoma brucei 6PGDH expressed in Escherichia coli by spectroscopy2010Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase.
AID100416In vitro antiparasitic activity was determined against Leishmania donovani2004Journal of medicinal chemistry, Jun-17, Volume: 47, Issue:13
Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues.
AID594836Inhibition of Francisella tularensis N-terminal hexahistidine-tagged arabinose phosphate isomerase expressed in Escherichia coli BL21(DE3) after 3 hrs2011Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9
Enediol mimics as inhibitors of the D-arabinose 5-phosphate isomerase (KdsD) from Francisella tularensis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
4-phosphoerythronate[no description available]medium304-phosphoerythronic acidEscherichia coli metabolite;
mouse metabolite
phenylmethanesulfonic acid[no description available]medium10
cysteic acid[no description available]medium10alanine derivative;
amino sulfonic acid;
carboxyalkanesulfonic acid;
cysteine derivative;
non-proteinogenic alpha-amino acid		animal metabolite
Thieno[3,2-b]thiophene-2-carboxylic acid[no description available]medium10thienothiophene
phosphoglycolohydroxamate[no description available]medium10amidoalkyl phosphate;
hydroxamic acid		EC 5.3.1.1 (triose-phosphate isomerase) inhibitor
n-bromoacetylethanolamine phosphate[no description available]medium10
amphotericin b[no description available]medium10antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
African Sleeping Sickness0low10
African Trypanosomiasis0low10
Nagana0low10
Trypanosomiasis, African0low10

Research Highlights

Bioavailability (1)

ArticleYear
Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase.
Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue: 14		2010
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]