Any EC 5.3.1.* (intramolecular oxidoreductase interconverting aldoses and ketoses) inhibitor that interferes with the action of a triose-phosphate isomerase (EC 5.3.1.1).
ChEBI ID: 90691
| Member | Definition | Class |
|---|---|---|
| phosphoglycolohydroxamate | The hydroxamate of phosphoglycolic acid. | phosphoglycolohydroxamic acid |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 10 (35.71) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 8 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 28 (100.00%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, Methylglyoxal Synthase | Escherichia coli | Ki | 0.0390 | 1 | 1 |
| Chain B, TRIOSEPHOSPHATE ISOMERASE | Trypanosoma brucei brucei | Ki | 4.0000 | 1 | 1 |
| Chain F, Methylglyoxal Synthase | Escherichia coli | Ki | 0.0390 | 1 | 1 |
| Fructose-bisphosphate aldolase A | Oryctolagus cuniculus (rabbit) | Ki | 1.0000 | 1 | 1 |
| Fructose-bisphosphate aldolase class 2 | Escherichia coli K-12 | Ki | 0.0100 | 1 | 1 |
| Triosephosphate isomerase | Homo sapiens (human) | Ki | 3.5000 | 2 | 2 |