Page last updated: 2024-08-05 15:24:51

EC 5.3.1.1 (triose-phosphate isomerase) inhibitor

Any EC 5.3.1.* (intramolecular oxidoreductase interconverting aldoses and ketoses) inhibitor that interferes with the action of a triose-phosphate isomerase (EC 5.3.1.1).

ChEBI ID: 90691

Members (1)

MemberDefinitionClass
phosphoglycolohydroxamateThe hydroxamate of phosphoglycolic acid.phosphoglycolohydroxamic acid

Research

Studies (28)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901 (3.57)18.7374
1990's10 (35.71)18.2507
2000's9 (32.14)29.6817
2010's8 (28.57)24.3611
2020's0 (0.00)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other28 (100.00%)84.16%

Protein Targets (6)

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, Methylglyoxal SynthaseEscherichia coliKi0.039011
Chain B, TRIOSEPHOSPHATE ISOMERASETrypanosoma brucei bruceiKi4.000011
Chain F, Methylglyoxal SynthaseEscherichia coliKi0.039011
Fructose-bisphosphate aldolase AOryctolagus cuniculus (rabbit)Ki1.000011
Fructose-bisphosphate aldolase class 2Escherichia coli K-12Ki0.010011
Triosephosphate isomeraseHomo sapiens (human)Ki3.500022