Page last updated: 2024-11-06

4-ketocyclophosphamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

4-ketocyclophosphamide: metabolite of cyclophosphamide; RN given refers to cpd without isomeric designation; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID33676
CHEMBL ID3544546
CHEBI ID1887
SCHEMBL ID23802152
MeSH IDM0051893

Synonyms (34)

Synonym
nsc-139488
oxo-endoxan
4-oxocyclophosphamide
4h-1,2-oxazaphosphorin-4-one, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide
nsc139488
nsc 139488
ccris 5128
4h-1,3,2-oxazophosphorin-4-one, 2-(bis(2-chloroethyl)amino)tetrahydro-, 2-oxide
2-(bis(2-chloroethyl)amino)tetrahydro-4h-1,3,2-oxazaphosphorin-4-one 2-oxide
asta 5160
brn 5582971
4-ketocyclophosphamide
27046-19-1
C07644
4-oxo cyclophosphamide
2-[bis(2-chloroethyl)amino]-1,3,2
n9du5qvf19 ,
4h-1,3,2-oxazaphosphorin-4-one, 2-(bis(2-chloroethyl)amino)tetrahydro-, 2-oxide
unii-n9du5qvf19
FT-0673363
ketocyclophosphamide, 4-
CHEBI:1887 ,
VBMZHOCORXMDJU-UHFFFAOYSA-N
2-[bis(2-chloroethyl)amino]-1,3,2-oxazaphosphinan-4-one 2-oxide #
2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2$l^{5}-oxazaphosphinan-4-one
CHEMBL3544546
J-016657
Q27105518
2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2lambda5-oxazaphosphinan-4-one
DTXSID501031077
SCHEMBL23802152
PD150830
AKOS040754750
2-[bis(2-chloroethyl)amino]-1,3,2|e?-oxazaphosphinane-2,4-dione

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" A population pharmacokinetic model for cyclophosphamide was developed using non-linear mixed effects modelling and metabolite AUC values were compared between days and courses."( Pharmacokinetics of cyclophosphamide and its metabolites in paediatric patients receiving high-dose myeloablative therapy.
Boddy, AV; Chinnaswamy, G; Cole, M; Errington, J; Foot, A; Veal, GJ, 2011
)
0.37
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
nitrogen mustardCompounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (2)

PathwayProteinsCompounds
Cyclophosphamide Action Pathway922
Cyclophosphamide Metabolism Pathway922

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (66.67)18.7374
1990's2 (16.67)18.2507
2000's1 (8.33)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]