Page last updated: 2024-12-05
4-iodoaniline
4-Iodoaniline is an organic compound with the formula C6H4(NH2)I. It is a white to light yellow solid. It is used as an intermediate in the synthesis of pharmaceuticals, dyes, and other fine chemicals. 4-Iodoaniline can be synthesized by the reaction of aniline with iodine in the presence of a base. 4-Iodoaniline is a key starting material for the synthesis of many important pharmaceutical compounds, such as the anti-inflammatory drug celecoxib and the anti-cancer drug imatinib. It is also used in the synthesis of dyes, such as the blue dye indigo. 4-Iodoaniline is studied because it is a versatile building block for the synthesis of many different organic compounds. It is also used in the development of new synthetic methods.'
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 10893 |
| CHEMBL ID | 41790 |
| SCHEMBL ID | 25837 |
| MeSH ID | M0060536 |
Synonyms (58)
| Synonym |
|---|
| AC-5104 |
| 0bmk56397b , |
| unii-0bmk56397b |
| ccris 9122 |
| 4-iodobenzenamine |
| einecs 208-743-4 |
| nsc 9246 |
| (4-iodophenyl)-amine |
| 4-iodo-aniline |
| 4-iodoaniline , |
| nsc-9246 |
| aniline, p-iodo- |
| aniline, 4-iodo- |
| benzenamine, 4-iodo- |
| wln: zr di |
| p-aminophenyl iodide |
| 540-37-4 |
| p-iodoaniline |
| nsc9246 |
| STK358767 |
| vlvcdusvtxiwgw-uhfffaoysa- |
| inchi=1/c6h6in/c7-5-1-3-6(8)4-2-5/h1-4h,8h2 |
| 4-iodoaniline, 98% |
| 4-iodo-phenylamine |
| I0048 |
| AKOS000119850 |
| A7856 |
| 4-iodophenylamine |
| CHEMBL41790 |
| 4-iodo-benzenamine |
| 4-iodanylaniline |
| A829920 |
| BP-20434 |
| FT-0618776 |
| PS-5431 |
| AM20040674 |
| AB01003215-01 |
| SCHEMBL25837 |
| iodoaniline, p- |
| p-aminoiodobenzene |
| p-iodoaniline [mi] |
| 4-iodobenzeneamine |
| p-iodo-aniline |
| p-iodo aniline |
| para-amino-iodo-benzene |
| 1-amino-4-iodo-benzene |
| DTXSID9060239 |
| Q-103463 |
| mfcd00007848 |
| F0001-1412 |
| CS-W008946 |
| 4-iodoaniline, purum, >=97.0% (nt) |
| BCP23259 |
| SY013885 |
| D70848 |
| Q27236574 |
| EN300-17968 |
| Z57127369 |
Research Excerpts
Dosage Studied
| Excerpt | Relevance | Reference |
|---|
| "The potential for neurotoxicity after a single oral dose of four halogenated aniline derivatives--4-bromoaniline (4-BA), 4-chloroaniline (4-CA), 4- fluoroaniline (4-FA) and 4-iodoaniline (4-IA)--was given to rats was investigated at or near the lethal dosage level." | ( Potential of neurotoxicity after a single oral dose of 4-bromo-, 4-chloro-, 4-fluoro- or 4-iodoaniline in rats.
Ishii, H; Okazaki, Y; Sudo, M; Tsuchitani, M; Yamashita, K, ) | 0.55 |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 38.88
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 38.88 (24.57) | | Research Supply Index | 1.95 (2.92) | | Research Growth Index | 4.32 (4.65) | | Search Engine Demand Index | 50.43 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |