2,6-diethylaniline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,6-Diethylaniline is an organic compound with the formula C10H15N. It is a colorless liquid that is used as an intermediate in the synthesis of dyes, pharmaceuticals, and other organic compounds. The compound is typically synthesized via the reduction of 2,6-dinitroethylbenzene using either catalytic hydrogenation or iron in acidic conditions. 2,6-Diethylaniline is an important intermediate in the synthesis of several drugs including antimalarials, antiseptics, and local anesthetics. The compound is also studied for its potential application in the synthesis of novel organic materials, such as conducting polymers.'

2,6-diethylaniline: one of the major metabolites of the herbicide alachlor [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	11369
CHEMBL ID	3184218
SCHEMBL ID	262868
MeSH ID	M0227362

Synonyms (58)

Synonym
4-12-00-02841 (beilstein handbook reference)
vt2234594h ,
unii-vt2234594h
2,6-diethyl aniline
benzamine, 2,6-diethyl-
ai3-26297
brn 1423626
hsdb 5699
einecs 209-445-7
ccris 2688
2,6-diethylbenzenamine
benzenamine, 2,6-diethyl-
aniline, 2,6-diethyl-
2,6-diethylaniline
579-66-8
inchi=1/c10h15n/c1-3-8-6-5-7-9(4-2)10(8)11/h5-7h,3-4,11h2,1-2h
2,6-diethylaniline, 98%
D0476
diethylaminobenzene
2-amino-1,3-diethylbenzene
2,6 diethylaniline
AKOS000120339
A831688
NCGC00247995-02
NCGC00247995-01
(2,6-diethyl-phenyl)-amine
2,6-diethyl-aniline
dtxsid6027218 ,
tox21_202010
dtxcid607218
NCGC00259559-01
cas-579-66-8
tox21_300333
NCGC00254454-01
2,6-diethylphenylamine
FT-0610638
2,6-diethylaniline [hsdb]
SCHEMBL262868
2.6-diethylaniline
4-iodopyridine-2,6-dicarboxylicacid
W-105426
CHEMBL3184218
mfcd00007753
AC-10108
2,6-diethylaniline, >=99.5%
2,6-diethylaniline, pestanal(r), analytical standard
2,6-diethyl-benzenamine
2,6-diethyl-benzamine
2,6-diethylbenzenamine, 9ci
CS-W018171
F0001-1508
STL570693
DS-13621
Q209276
AM10640
D77824
EN300-20612
Z104479240

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" ANOVA analyses indicated that there is a dose-response relationship between doses of N,N-diethylaniline and the frequency of SCEs, especially in the presence of S-9 mix."	( Sister chromatid exchanges of human peripheral blood lymphocytes induced by N,N-diethylaniline in vitro. Li, Q; Minami, M, 1997)	0.3

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pathways (1)

Pathway	Proteins	Compounds
butachlor degradation	0	13

Protein Targets (2)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	33.8626	0.0002	29.3054	16,493.5996	AID743075
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	61.9001	0.0003	23.4451	159.6830	AID743065; AID743067
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	5 (45.45)	18.2507
2000's	3 (27.27)	29.6817
2010's	3 (27.27)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.19

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	33.19 (24.57)
Research Supply Index	2.56 (2.92)
Research Growth Index	4.44 (4.65)
Search Engine Demand Index	37.47 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (33.19)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
iodine Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.. diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..	7.03	1	diatomic iodine	nutrient
alachlor alachlor : An aromatic amide that is N-(2,6-diethylphenyl)acetamide substituted by a methoxymethyl group at at the nitrogen atom while one of the hydrogens of the methyl group has been replaced by a chlorine atom.	8.1	5	aromatic amide; monocarboxylic acid amide; organochlorine compound	environmental contaminant; herbicide; xenobiotic
benzophenone benzophenone : The simplest member of the class of benzophenones, being formaldehyde in which both hydrogens are replaced by phenyl groups.	2.03	1	benzophenones	photosensitizing agent; plant metabolite
n,n-diethylaniline N,N-diethylaniline: a reagent and an intermediate in manufacturing of dyes	1.99	1
dimethyl-4-toluidine [no description available]	2.03	1
anthracene acene : A polycyclic aromatic hydrocarbon consisting of fused benzene rings in a rectilinear arrangement.. acenes : Polycyclic aromatic hydrocarbons consisting of fused benzene rings in a rectilinear arrangement and their substitution derivatives.	2.07	1	acene; anthracenes; ortho-fused tricyclic hydrocarbon
silver Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.	2.07	1	copper group element atom; elemental silver	Escherichia coli metabolite
2-chloro-n-(ethoxymethyl)-n-(2-methyl-6-(trifluoromethyl)phenyl)acetamide 2-chloro-N-(ethoxymethyl)-N-(2-methyl-6-(trifluoromethyl)phenyl)acetamide: structure given in first source	2.15	1
cytochalasin b Cytochalasin B: A cytotoxic member of the CYTOCHALASINS.. cytochalasin B : An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.	2	1	cytochalasin; lactam; lactone; organic heterotricyclic compound	actin polymerisation inhibitor; metabolite; mycotoxin; platelet aggregation inhibitor

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