Compounds > 2'-deoxyadenosine-3',5'-diphosphate

Page last updated: 2024-11-12

2'-deoxyadenosine-3',5'-diphosphate

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Description

2'-deoxyadenosine-3',5'-diphosphate: a zinc ion chelating agent; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	14252049
CHEMBL ID	1230817
SCHEMBL ID	375910
MeSH ID	M0514213

Synonyms (6)

Synonym
CHEMBL1230817
2'-deoxy-adenosine-3'-5'-diphosphate
2'-deoxyadenosine-3',5'-diphosphate
SCHEMBL375910
2'-deoxyadenosine 3',5'-bis(dihydrogen phosphate)
Q27457216

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
P2Y purinoceptor 1	Meleagris gallopavo (turkey)	IC50 (µMol)	5.7600	4.1900	6.0425	8.4600	AID150475; AID165239
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
P2Y purinoceptor 1	Meleagris gallopavo (turkey)	EC50 (µMol)	6.2750	0.0025	1.7049	8.0000	AID150468; AID165236
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay ID	Title	Year	Journal	Article
AID150485	In vitro agonistic activity was determined for stimulation of PLC at Turkey erythrocyte P2Y purinoceptor 1	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	Acyclic analogues of deoxyadenosine 3',5'-bisphosphates as P2Y(1) receptor antagonists.
AID150479	Antagonist activity for inhibition of PLC elicited by 10 nM 2-MeSADP at P2Y purinoceptor 1 in turkey erythrocyte membranes	1999	Journal of medicinal chemistry, May-06, Volume: 42, Issue:9	Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.
AID165243	Antagonist activity at P2Y1 receptor measured as capacity to inhibit phospholipase C stimulation elicited by 10 nM 2-MeSATP	1998	Journal of medicinal chemistry, Jan-15, Volume: 41, Issue:2	Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors.
AID150477	Agonist activity for stimulation of PLC at P2Y purinoceptor 1 in the turkey erythrocyte membranes.	1999	Journal of medicinal chemistry, May-06, Volume: 42, Issue:9	Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.
AID215612	Tested in vitro for effective concentration required for stimulation of phospholipase C (PLC) against [3H]inositol labeled Turkey Erythrocyte P2Y purinoceptor 1	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	Acyclic analogues of deoxyadenosine 3',5'-bisphosphates as P2Y(1) receptor antagonists.
AID215615	Antagonism of PLC stimulation elicited by 10(nM) 2-Me SADP in turkey RBC	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	Acyclic analogues of deoxyadenosine 3',5'-bisphosphates as P2Y(1) receptor antagonists.
AID215616	Antagonism of PLC stimulation elicited by 30(nM) 2-Me SADP in turkey RBC	2000	Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4	Acyclic analogues of deoxyadenosine 3',5'-bisphosphates as P2Y(1) receptor antagonists.
AID165236	Agonist activity at P2Y1 receptor measured as capacity to stimulate 50% phospholipase C in turkey erythrocyte membranes	1998	Journal of medicinal chemistry, Jan-15, Volume: 41, Issue:2	Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors.
AID165240	Agonist activity at P2Y1 receptor measured as capacity to stimulate phospholipase C in turkey erythrocyte membranes	1998	Journal of medicinal chemistry, Jan-15, Volume: 41, Issue:2	Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors.
AID150468	Concentration at which 50% of the maximal effect (stimulation of PLC at P2Y1 receptor in the turkey erythrocyte membranes) is reached	1999	Journal of medicinal chemistry, May-06, Volume: 42, Issue:9	Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.
AID165239	Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATP	1998	Journal of medicinal chemistry, Jan-15, Volume: 41, Issue:2	Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors.
AID150475	In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.	1999	Journal of medicinal chemistry, May-06, Volume: 42, Issue:9	Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (33.33)	18.2507
2000's	2 (33.33)	29.6817
2010's	2 (33.33)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.36

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.36 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.31 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.36)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
adenosine diphosphate Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.	2.75	3	0	adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	fundamental metabolite; human metabolite
2'-deoxyadenosine 2'-deoxyformycin A: RN not in Chemline 9/85; RN and structure given in first source	2.05	1	0	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
thymidine 3',5'-diphosphate [no description available]	2	1	0
adenosine 3'-phosphate-5'-phosphate adenosine 3',5'-bismonophosphate : An adenosine bisphosphate having two monophosphate groups at the 3'- and 5'-positions.	2.4	2	0	adenosine bisphosphate	Escherichia coli metabolite; mouse metabolite
adenosine 2',5'-diphosphate [no description available]	1.99	1	0
guanosine diphosphate Guanosine Diphosphate: A guanine nucleotide containing two phosphate groups esterified to the sugar moiety.	2.47	2	0	guanosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	Escherichia coli metabolite; mouse metabolite; uncoupling protein inhibitor
2'-deoxyguanosine 3',5'-diphosphate 2'-deoxyguanosine 3',5'-diphosphate: a zinc ion chelating agent	2.73	3	0