Compounds > strychnine n-oxide
Page last updated: 2024-12-06

strychnine n-oxide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

strychnine N-oxide: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

strychnine N-oxide : A tertiary amine oxide resulting from the oxidation of the non-acylated nitrogen of strychnine. It is a metabolite of strychnine. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID73393
CHEMBL ID138585
CHEBI ID132703
MeSH IDM0221131

Synonyms (36)

Synonym
2-27-00-00739 (beilstein handbook reference)
774c760v46 ,
unii-774c760v46
n-oxystrychnine
strychnine n6-oxide
nsc127569
nsc-127569
strychnine, n-oxide
strychnine n-oxide
7248-28-4
genostrychnine
strychnine, 19-oxide
strychnidin-10-one, 19-oxide
alkaloids, n.o.s.
NSC24951 ,
mls000738032 ,
nsc-24951
smr000393707
strychnine, n6-oxide
strychnine-n-oxide
nsc 127569
einecs 230-656-5
brn 0102320
nsc 24951
strychnin-n6-oxide
CHEBI:132703
strychnine 19-oxide
strychnine n(6)-oxide
(1s,11s,18s,20r,21r,22s)-12-oxa-8,17-diazaheptacyclo[15.5.2.0(1,18).0(2,7).0(8,22).0(11,21).0(15,20)]tetracosa-2,4,6,14-tetraen-9-one 17-oxide
CHEMBL138585
strychnine n6-oxide [mi]
strychnidin-10-one 19-oxide
strychnine_n_oxide
7-oxo-6,7,7a,8,8a,11,12a,12b,12c,13-decahydro-5h,14h-7,9-methano-12-oxa-7lambda~5~,14a-diazacyclohepta[1,2,3-cd]cyclopenta[g]fluoranthen-14-one
DTXSID80993305
Q27225624

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
"To study the pharmacokinetic process about the concentration in rat plasma of the alkaloids from processed seeds of Strychnos nux-vomica with RP-HPLC method."( [Pharmacokinetics of the alkaloids from the processed seeds of Strychnos nux-vomica in rats].
Cai, BC; Pan, Y; Wang, TS; Xu, XY, 2003)		0.32
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
organic heteroheptacyclic compound
monoterpenoid indole alkaloidA terpenoid indole alkaloid which is biosynthesised from L-tryptophan and diisoprenoid (usually secolaganin) building blocks.
tertiary amine oxideAn N-oxide where there are three organic groups bonded to the nitrogen atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (21)

Assay IDTitleYearJournalArticle
AID140914Cooperativity with NMS at human muscarinic acetylcholine receptor M11999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
AID141753Cooperativity with NMS at human muscarinic acetylcholine receptor M41999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
AID697151Cytotoxicity against human SW480 cells after 48 hrs by MTT assay2012Journal of natural products, Nov-26, Volume: 75, Issue:11
Strynuxlines A and B, alkaloids with an unprecedented carbon skeleton from Strychnos nux-vomica.
AID697153Cytotoxicity against human A549 cells after 48 hrs by MTT assay2012Journal of natural products, Nov-26, Volume: 75, Issue:11
Strynuxlines A and B, alkaloids with an unprecedented carbon skeleton from Strychnos nux-vomica.
AID141751Binding affinity at the unliganded human muscarinic acetylcholine receptor M4 was estimated as log affinity (log1/M)1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
AID141332Binding affinity at the unliganded human muscarinic acetylcholine receptor M3 was estimated as log affinity (log1/M)1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
AID142259Binding affinity at the NMS liganded human muscarinic acetylcholine receptor M2 was estimated as log affinity (log1/M)1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
AID142262Cooperativity with NMS at human muscarinic acetylcholine receptor M21999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
AID140915Cooperativity with acetylcholine at human muscarinic acetylcholine receptor M11999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
AID141754Cooperativity with acetylcholine at human muscarinic acetylcholine receptor M41999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
AID140907Binding affinity at the unliganded human muscarinic acetylcholine receptor M1 was estimated as log affinity (log1/M)1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
AID141337Cooperativity with NMS at human muscarinic acetylcholine receptor M31999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
AID697155Cytotoxicity against human HL60 cells after 48 hrs by MTT assay2012Journal of natural products, Nov-26, Volume: 75, Issue:11
Strynuxlines A and B, alkaloids with an unprecedented carbon skeleton from Strychnos nux-vomica.
AID142260Binding affinity at the unliganded human muscarinic acetylcholine receptor M2 was estimated as log affinity (log1/M)1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
AID697154Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay2012Journal of natural products, Nov-26, Volume: 75, Issue:11
Strynuxlines A and B, alkaloids with an unprecedented carbon skeleton from Strychnos nux-vomica.
AID141338Cooperativity with acetylcholine at human muscarinic acetylcholine receptor M31999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
AID141331Binding affinity at the NMS liganded human muscarinic acetylcholine receptor M3 was estimated as log affinity (log1/M)1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
AID140906Binding affinity at the NMS liganded human muscarinic acetylcholine receptor M1 was estimated as log affinity (log1/M)1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
AID141750Binding affinity at the NMS liganded human muscarinic acetylcholine receptor M4 was estimated as log affinity (log1/M)1999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
AID697152Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay2012Journal of natural products, Nov-26, Volume: 75, Issue:11
Strynuxlines A and B, alkaloids with an unprecedented carbon skeleton from Strychnos nux-vomica.
AID142263Cooperativity with acetylcholine at human muscarinic acetylcholine receptor M21999Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (42.11)18.7374
1990's3 (15.79)18.2507
2000's1 (5.26)29.6817
2010's6 (31.58)24.3611
2020's1 (5.26)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.26

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.26 (24.57)
Research Supply Index3.00 (2.92)
Research Growth Index5.25 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.26)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.26%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (94.74%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
indole
[no description available]		2.1310indole;
polycyclic heteroarene		Escherichia coli metabolite
strychnine
Strychnine: An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.. strychnine : A monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position.		5.36190monoterpenoid indole alkaloid;
organic heteroheptacyclic compound		avicide;
cholinergic antagonist;
glycine receptor antagonist;
neurotransmitter agent;
rodenticide
brucine
brucine: was heading 1991-94 (see under STRYCHNINE 1975-90); DIMETHOXYSTRYCHNINE was see BRUCINE 1975-94; use STRYCHNINE to search BRUCINE 1975-94; very toxic alkaloid from Nux vomica similar to strychnine; used as reagent in analytical chemistry; was MH 1991-94		8.1450monoterpenoid indole alkaloid;
organic heteroheptacyclic compound
isosungucine
isosungucine: isolated from Strychnos icaja; structure in first source		2.1310
brucine n-oxide
brucine N-oxide: structure given in first source		4.3860
ConditionIndicatedRelationship StrengthStudiesTrials
Abortion, Tubal
[description not available]		02.6230
Abortion, Spontaneous
Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.		02.6230
Poisoning
Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.		02.3320
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.6230
Cardiac Death
[description not available]		01.9210
Bedwetting
[description not available]		01.9210
Nocturnal Enuresis
Involuntary discharge of URINE during sleep at night after expected age of completed development of urinary control.		01.9210