Page last updated: 2024-11-13
vindolinine
Description
vindolinine: alkaloid isolated from Catharanthus trichophyllus roots & Vinca rosea (Catharanthus); tested against experimental neoplasms; RN given refers to (2alpha,3beta,5alpha,12beta,19alpha,20R)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
vindolinine : A monoterpenoid indole alkaloid with formula C21H24N2O2, isolated from several plant species. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|
| Vinca | genus | A plant genus of the family Apocynaceae.[MeSH] | Apocynaceae | The dogbane family of the order Gentianales. Members of the family have milky, often poisonous juice, smooth-margined leaves, and flowers in clusters.[MeSH] |
| Catharanthus | genus | A plant genus of the family Apocynaceae. It is the source of VINCA ALKALOIDS, used in leukemia chemotherapy.[MeSH] | Apocynaceae | The dogbane family of the order Gentianales. Members of the family have milky, often poisonous juice, smooth-margined leaves, and flowers in clusters.[MeSH] |
| Catharanthus trichophyllus | species | [no description available] | Apocynaceae | The dogbane family of the order Gentianales. Members of the family have milky, often poisonous juice, smooth-margined leaves, and flowers in clusters.[MeSH] |
Cross-References
Synonyms (13)
| Synonym |
|---|
| vindolinine |
| MEGXP0_001942 |
| CHEMBL1165590 |
| (-)-vindolinine |
| 5980-02-9 |
| CHEBI:141964 |
| vindolinin |
| methyl (3beta,5alpha,12beta,19alpha,20r)-6,7-didehydro-2,20-cycloaspidospermidine-3-carboxylate |
| (2alpha,3beta,5alpha,12beta,19alpha,20r)-6,7-didehydro-2,20-cycloaspidospermidine-3-carbox ylic acid, methyl ester |
| methyl (1r,9r,10r,12r,19s,20r)-20-methyl-8,16-diazahexacyclo[10.6.1.19,12.01,9.02,7.016,19]icosa-2,4,6,13-tetraene-10-carboxylate |
| CS-0032446 |
| HY-N5122 |
| AKOS040760748 |
Roles (1)
| Role | Description |
|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (4)
| Class | Description |
|---|
| monoterpenoid indole alkaloid | A terpenoid indole alkaloid which is biosynthesised from L-tryptophan and diisoprenoid (usually secolaganin) building blocks. |
| tertiary amino compound | A compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups. |
| methyl ester | Any carboxylic ester resulting from the formal condensation of a carboxy group with methanol. |
| organic heteropentacyclic compound | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Bioassays (5)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID488587 | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Jun-25, Volume: 73, Issue:6
| Cytotoxic indole alkaloids from Melodinus tenuicaudatus. |
| AID488588 | Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Jun-25, Volume: 73, Issue:6
| Cytotoxic indole alkaloids from Melodinus tenuicaudatus. |
| AID488591 | Cytotoxicity against human SW480 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Jun-25, Volume: 73, Issue:6
| Cytotoxic indole alkaloids from Melodinus tenuicaudatus. |
| AID488590 | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Jun-25, Volume: 73, Issue:6
| Cytotoxic indole alkaloids from Melodinus tenuicaudatus. |
| AID488589 | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | 2010 | Journal of natural products, Jun-25, Volume: 73, Issue:6
| Cytotoxic indole alkaloids from Melodinus tenuicaudatus. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 20.35
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 20.35 (24.57) | | Research Supply Index | 1.95 (2.92) | | Research Growth Index | 4.66 (4.65) | | Search Engine Demand Index | 15.26 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |