Page last updated: 2024-10-24
chemokine (C-C motif) ligand 5 binding
Definition
Target type: molecularfunction
Binding to chemokine (C-C motif) ligand 5. [GOC:add, GOC:amm]
Chemokine (C-C motif) ligand 5 (CCL5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), plays a crucial role in immune cell trafficking and inflammation. Its primary molecular function involves binding to specific G protein-coupled receptors (GPCRs) on the surface of immune cells, primarily CCR1, CCR3, and CCR5. Upon binding to these receptors, CCL5 triggers a signaling cascade that ultimately leads to the activation and migration of various immune cells, including T lymphocytes, monocytes, and eosinophils. CCL5 binding to CCR5 is particularly important in the context of HIV infection, as CCR5 serves as a co-receptor for HIV entry into cells. By binding to CCR5, CCL5 can block HIV entry and prevent infection. In addition to its role in immune cell trafficking, CCL5 also contributes to wound healing, angiogenesis, and the development of certain types of cancer.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| C-C chemokine receptor type 5 | A C-C chemokine receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51681] | Homo sapiens (human) |
| C-C chemokine receptor type 1 | A C-C chemokine receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32246] | Homo sapiens (human) |
Compounds (27)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 1,10-phenanthroline | 1,10-phenanthroline: RN given refers to parent cpd; inhibits Zn-dependent metalloproteinases | phenanthroline | EC 2.7.1.1 (hexokinase) inhibitor; EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor |
| 2,2'-dipyridyl | 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'. 2,2'-Dipyridyl: A reagent used for the determination of iron. | bipyridine | chelator; ferroptosis inhibitor |
| disulfiram | organic disulfide; organosulfur acaricide | angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor; EC 3.1.1.1 (carboxylesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 5.99.1.2 (DNA topoisomerase) inhibitor; ferroptosis inducer; fungicide; NF-kappaB inhibitor | |
| terfenadine | Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME. | diarylmethane | |
| 4,4'-dimethyl-2,2'-bipyridine | 4,4'-dimethyl-2,2'-bipyridine: structure in first source | ||
| 5,5'-dimethyl-2,2'-bipyridyl | 5,5'-dimethyl-2,2'-bipyridyl: structure in first source | bipyridines | |
| neocuproine | neocuproine : A member of the class of phenanthrolines that is 1,10-phenanthroline bearing two methyl substituents at positions 2 and 9. neocuproine: Spectrophotometric determination of copper and ultramicro blood sugar determinations; structure; RN given refers to parent cpd | phenanthrolines | chelator; copper chelator |
| 2,2',2''-terpyridine | 2,2',2''-terpyridine: RN given refers to parent cpd 2,2':6',2''-terpyridine : A tridentate heterocyclic ligand that binds metals at three meridional sites giving two adjacent 5-membered MN2C2 chelate rings. | terpyridines | chelator |
| 5-methyl-1,10-phenanthroline | |||
| 3,4,7,8-tetramethyl-1,10-phenanthroline | |||
| tak 779 | |||
| bx 471 | BX 471: a CC chemokine receptor-1 antagonist; structure in first source | ||
| aplaviroc | aplaviroc: a spiro-diketo-piperazine; a potent noncompetitive allosteric antagonist of the CCR5 receptor with concomitantly potent antiviral effects for HIV-1; structure in first source | ||
| maraviroc | tropane alkaloid | ||
| vicriviroc | vicriviroc: structure in first source | (trifluoromethyl)benzenes | |
| tak-220 | TAK-220: structure in first source | ||
| cp 481715 | quinoxaline-2-carboxylic acid (4-carbamoyl-1-(3-fluorobenzyl)-2,7-dihydroxy-7-methyloctyl)amide: a CCR1 antagonist and NSAID; structure in first source | ||
| ancriviroc | Ancriviroc: CCR5 receptor antagonist | aromatic carboxylic acid; pyridinemonocarboxylic acid | |
| variecolin | variecolin: structure in first source | enal; sesterterpenoid | Aspergillus metabolite |
| ucb 35625 | UCB 35625: J-113863 is the (trans)-isomer; structure in first source | ||
| vuf 2274 | 5-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-2,2-diphenylpentanenitrile: an inverse agonist of human cytomegalovirus; structure in first source | ||
| amd 070 | mavorixafor: a derivative of AMD3100; a CXCR4 blocker | aminoquinoline | |
| cenicriviroc | cenicriviroc : A member of the class of benzazocines that is (5Z)-1,2,3,4-tetrahydro-1-benzazocine which is substituted by a 2-methylpropyl, N-{4-[(S)-(1-propyl-1H-imidazol-5-yl)methanesulfinyl]phenyl}carboxamide and 4-(2-butoxyethoxy)phenyl groups at positions 1, 5 and 8, respectively. It is a potent chemokine 2 and 5 receptor antagonist currently in development for the treatment of liver fibrosis in adults with nonalcoholic steatohepatitis (NASH). cenicriviroc: an inhibitor of HIV-1 | aromatic ether; benzazocine; diether; imidazoles; secondary carboxamide; sulfoxide | anti-HIV agent; anti-inflammatory agent; antirheumatic drug; chemokine receptor 2 antagonist; chemokine receptor 5 antagonist |
| a 803467 | A 803467: an Nav1.8 sodium channel blocker; structure in first source | ||
| 19,20-epoxycytochalasin q | 19,20-epoxycytochalasin Q: from Xylaria sp.; structure in first source | ||
| raltegravir | 1,2,4-oxadiazole; dicarboxylic acid amide; hydroxypyrimidine; monofluorobenzenes; pyrimidone; secondary carboxamide | antiviral drug; HIV-1 integrase inhibitor | |
| fuscin | fuscin: antibacterial pigment produced by the fungus Didiodendron fuscom; minor descriptor (75-82); online & Index Medicus search BENZOPYRANS (75-82) |