cholecystokinin receptor activity

Definition

Target type: molecularfunction

Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone. [GOC:signaling, PMID:9835394]

Cholecystokinin receptor activity refers to the biological process by which a cell responds to the presence of cholecystokinin (CCK). CCK is a hormone and neurotransmitter that plays a crucial role in digestion, appetite regulation, and pancreatic function. CCK receptors, specifically CCK receptor type A (CCKAR-A) and CCK receptor type B (CCKAR-B), are G protein-coupled receptors (GPCRs) located on the cell surface. Upon binding of CCK to its receptor, a series of events are triggered, leading to downstream signaling pathways.

When CCK binds to CCKAR-A, it activates a signaling cascade that ultimately results in the release of digestive enzymes from the pancreas and the contraction of the gallbladder, facilitating the release of bile. CCKAR-A activation also plays a role in satiety and appetite regulation by signaling to the brain, reducing food intake.

CCKAR-B, on the other hand, is mainly found in the brain and peripheral tissues. Its activation is involved in the regulation of anxiety, pain perception, and neuronal development.

The molecular function of cholecystokinin receptor activity, therefore, involves the complex interaction of CCK with its receptors, activating signaling pathways that mediate a wide range of physiological processes, including digestion, appetite regulation, and neuronal function.'
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Proteins (2)

Compounds (33)